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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

Gene

murA1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93UDP-N-acetylglucosamineUniRule annotation1
Active sitei117Proton donorUniRule annotation1
Binding sitei306UDP-N-acetylglucosamineUniRule annotation1
Binding sitei328UDP-N-acetylglucosamine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciANTHRA:MURA1-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1UniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferase 1UniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferase 1UniRule annotation
Short name:
EPT 1UniRule annotation
Gene namesi
Name:murA1UniRule annotation
Ordered Locus Names:BA_5529, GBAA_5529, BAS5137
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002311531 – 434UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1172-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_5529.

Structurei

Secondary structure

1434
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Beta strandi13 – 16Combined sources4
Helixi22 – 31Combined sources10
Helixi32 – 34Combined sources3
Beta strandi37 – 44Combined sources8
Helixi49 – 60Combined sources12
Beta strandi64 – 68Combined sources5
Beta strandi71 – 75Combined sources5
Helixi86 – 91Combined sources6
Helixi93 – 98Combined sources6
Helixi99 – 106Combined sources8
Beta strandi107 – 112Combined sources6
Helixi125 – 133Combined sources9
Beta strandi136 – 141Combined sources6
Beta strandi144 – 152Combined sources9
Beta strandi157 – 159Combined sources3
Helixi165 – 175Combined sources11
Beta strandi178 – 186Combined sources9
Helixi191 – 202Combined sources12
Beta strandi212 – 218Combined sources7
Beta strandi227 – 229Combined sources3
Helixi234 – 247Combined sources14
Beta strandi250 – 253Combined sources4
Helixi258 – 260Combined sources3
Helixi262 – 270Combined sources9
Beta strandi274 – 276Combined sources3
Beta strandi279 – 285Combined sources7
Beta strandi288 – 291Combined sources4
Beta strandi295 – 297Combined sources3
Helixi305 – 307Combined sources3
Helixi308 – 315Combined sources8
Beta strandi318 – 329Combined sources12
Helixi336 – 341Combined sources6
Beta strandi346 – 349Combined sources4
Beta strandi352 – 358Combined sources7
Beta strandi365 – 367Combined sources3
Helixi371 – 381Combined sources11
Beta strandi384 – 386Combined sources3
Beta strandi388 – 391Combined sources4
Turni393 – 395Combined sources3
Helixi396 – 399Combined sources4
Helixi403 – 409Combined sources7
Beta strandi414 – 417Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SG1X-ray2.60A/B/C/D1-434[»]
ProteinModelPortaliQ81K13.
SMRiQ81K13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 23Phosphoenolpyruvate bindingUniRule annotation2
Regioni122 – 126UDP-N-acetylglucosamine bindingUniRule annotation5

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0766. LUCA.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.

Family and domain databases

CDDicd01555. UdpNAET. 1 hit.
Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA. 1 hit.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81K13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIIVRGGK RLNGTVRVEG AKNAVLPIIA AALLASDGKN VLSEVPVLSD
60 70 80 90 100
VYTINEVLRH LNAEVVFENN QVTIDASKEL NIEAPFEYVR KMRASVQVMG
110 120 130 140 150
PLLARNGRAR IALPGGCAIG SRPIDQHLKG FEAMGAKVQV GNGFVEAYVE
160 170 180 190 200
GELKGAKIYL DFPSVGATEN IMSAATLAKG TTILENAAKE PEIVDLANFL
210 220 230 240 250
NAMGAKVRGA GTGTIRIEGV DKLYGANHSI IPDRIEAGTF MVAAAITGGD
260 270 280 290 300
ILIENAVPEH LRSITAKMEE MGVKIIEENE GVRVIGPDKL KAVDIKTMPH
310 320 330 340 350
PGFPTDMQSQ MMALLLQADG TSMITETVFE NRFMHVEEFR RMNADIKIEG
360 370 380 390 400
RSVIMNGPNS LQGAEVGATD LRAAAALILA GLVSEGYTRV TELKHLDRGY
410 420 430
VDFHKKLAAL GATIERVNEK VEEVKEQEVS DLHA
Length:434
Mass (Da):46,773
Last modified:June 1, 2003 - v1
Checksum:i0C2E9D8741A59344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29173.1.
AE017334 Genomic DNA. Translation: AAT34672.1.
AE017225 Genomic DNA. Translation: AAT57426.1.
RefSeqiNP_847687.1. NC_003997.3.
WP_000411264.1. NZ_LHUO01000009.1.
YP_031376.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP29173; AAP29173; BA_5529.
AAT34672; AAT34672; GBAA_5529.
AAT57426; AAT57426; BAS5137.
GeneIDi1085196.
2848012.
KEGGiban:BA_5529.
bar:GBAA_5529.
bat:BAS5137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29173.1.
AE017334 Genomic DNA. Translation: AAT34672.1.
AE017225 Genomic DNA. Translation: AAT57426.1.
RefSeqiNP_847687.1. NC_003997.3.
WP_000411264.1. NZ_LHUO01000009.1.
YP_031376.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SG1X-ray2.60A/B/C/D1-434[»]
ProteinModelPortaliQ81K13.
SMRiQ81K13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_5529.

Protocols and materials databases

DNASUi1085196.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP29173; AAP29173; BA_5529.
AAT34672; AAT34672; GBAA_5529.
AAT57426; AAT57426; BAS5137.
GeneIDi1085196.
2848012.
KEGGiban:BA_5529.
bar:GBAA_5529.
bat:BAS5137.

Phylogenomic databases

eggNOGiCOG0766. LUCA.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciANTHRA:MURA1-MONOMER.

Family and domain databases

CDDicd01555. UdpNAET. 1 hit.
Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA. 1 hit.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURA1_BACAN
AccessioniPrimary (citable) accession number: Q81K13
Secondary accession number(s): Q6HQL2, Q6KJY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.