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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

Gene

murA1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Proton donorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciANTHRA:MURA1-MONOMER.
BANT260799:GJAJ-5212-MONOMER.
BANT261594:GJ7F-5390-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1UniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferase 1UniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferase 1UniRule annotation
Short name:
EPT 1UniRule annotation
Gene namesi
Name:murA1UniRule annotation
Ordered Locus Names:BA_5529, GBAA_5529, BAS5137
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1PRO_0000231153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 11712-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_5529.

Structurei

Secondary structure

1
434
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64Combined sources
Beta strandi13 – 164Combined sources
Helixi22 – 3110Combined sources
Helixi32 – 343Combined sources
Beta strandi37 – 448Combined sources
Helixi49 – 6012Combined sources
Beta strandi64 – 685Combined sources
Beta strandi71 – 755Combined sources
Helixi86 – 916Combined sources
Helixi93 – 986Combined sources
Helixi99 – 1068Combined sources
Beta strandi107 – 1126Combined sources
Helixi125 – 1339Combined sources
Beta strandi136 – 1416Combined sources
Beta strandi144 – 1529Combined sources
Beta strandi157 – 1593Combined sources
Helixi165 – 17511Combined sources
Beta strandi178 – 1869Combined sources
Helixi191 – 20212Combined sources
Beta strandi212 – 2187Combined sources
Beta strandi227 – 2293Combined sources
Helixi234 – 24714Combined sources
Beta strandi250 – 2534Combined sources
Helixi258 – 2603Combined sources
Helixi262 – 2709Combined sources
Beta strandi274 – 2763Combined sources
Beta strandi279 – 2857Combined sources
Beta strandi288 – 2914Combined sources
Beta strandi295 – 2973Combined sources
Helixi305 – 3073Combined sources
Helixi308 – 3158Combined sources
Beta strandi318 – 32912Combined sources
Helixi336 – 3416Combined sources
Beta strandi346 – 3494Combined sources
Beta strandi352 – 3587Combined sources
Beta strandi365 – 3673Combined sources
Helixi371 – 38111Combined sources
Beta strandi384 – 3863Combined sources
Beta strandi388 – 3914Combined sources
Turni393 – 3953Combined sources
Helixi396 – 3994Combined sources
Helixi403 – 4097Combined sources
Beta strandi414 – 4174Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SG1X-ray2.60A/B/C/D1-434[»]
ProteinModelPortaliQ81K13.
SMRiQ81K13. Positions 1-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0766. LUCA.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.
OrthoDBiEOG68M4GK.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81K13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIIVRGGK RLNGTVRVEG AKNAVLPIIA AALLASDGKN VLSEVPVLSD
60 70 80 90 100
VYTINEVLRH LNAEVVFENN QVTIDASKEL NIEAPFEYVR KMRASVQVMG
110 120 130 140 150
PLLARNGRAR IALPGGCAIG SRPIDQHLKG FEAMGAKVQV GNGFVEAYVE
160 170 180 190 200
GELKGAKIYL DFPSVGATEN IMSAATLAKG TTILENAAKE PEIVDLANFL
210 220 230 240 250
NAMGAKVRGA GTGTIRIEGV DKLYGANHSI IPDRIEAGTF MVAAAITGGD
260 270 280 290 300
ILIENAVPEH LRSITAKMEE MGVKIIEENE GVRVIGPDKL KAVDIKTMPH
310 320 330 340 350
PGFPTDMQSQ MMALLLQADG TSMITETVFE NRFMHVEEFR RMNADIKIEG
360 370 380 390 400
RSVIMNGPNS LQGAEVGATD LRAAAALILA GLVSEGYTRV TELKHLDRGY
410 420 430
VDFHKKLAAL GATIERVNEK VEEVKEQEVS DLHA
Length:434
Mass (Da):46,773
Last modified:June 1, 2003 - v1
Checksum:i0C2E9D8741A59344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29173.1.
AE017334 Genomic DNA. Translation: AAT34672.1.
AE017225 Genomic DNA. Translation: AAT57426.1.
RefSeqiNP_847687.1. NC_003997.3.
WP_000411264.1. NZ_LHUO01000009.1.
YP_031376.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP29173; AAP29173; BA_5529.
AAT34672; AAT34672; GBAA_5529.
AAT57426; AAT57426; BAS5137.
GeneIDi1085196.
2848012.
KEGGiban:BA_5529.
bar:GBAA_5529.
bat:BAS5137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29173.1.
AE017334 Genomic DNA. Translation: AAT34672.1.
AE017225 Genomic DNA. Translation: AAT57426.1.
RefSeqiNP_847687.1. NC_003997.3.
WP_000411264.1. NZ_LHUO01000009.1.
YP_031376.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SG1X-ray2.60A/B/C/D1-434[»]
ProteinModelPortaliQ81K13.
SMRiQ81K13. Positions 1-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_5529.

Protocols and materials databases

DNASUi1085196.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP29173; AAP29173; BA_5529.
AAT34672; AAT34672; GBAA_5529.
AAT57426; AAT57426; BAS5137.
GeneIDi1085196.
2848012.
KEGGiban:BA_5529.
bar:GBAA_5529.
bat:BAS5137.

Phylogenomic databases

eggNOGiCOG0766. LUCA.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.
OrthoDBiEOG68M4GK.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciANTHRA:MURA1-MONOMER.
BANT260799:GJAJ-5212-MONOMER.
BANT261594:GJ7F-5390-MONOMER.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiMURA1_BACAN
AccessioniPrimary (citable) accession number: Q81K13
Secondary accession number(s): Q6HQL2, Q6KJY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2003
Last modified: January 20, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.