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Protein

Thymidine kinase

Gene

tdk

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Binding sitei120Substrate; via amide nitrogen1
Metal bindingi145Zinc1
Metal bindingi148Zinc1
Binding sitei179SubstrateBy similarity1
Metal bindingi183Zinc1
Metal bindingi186Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17898

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:BA_5573, GBAA_5573, BAS5179
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749531 – 194Thymidine kinaseAdd BLAST194

Interactioni

Subunit structurei

Homotetramer.UniRule annotation1 Publication

Protein-protein interaction databases

IntActiQ81JX0, 5 interactors
STRINGi260799.BAS5179

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 14Combined sources6
Helixi21 – 34Combined sources14
Beta strandi39 – 43Combined sources5
Beta strandi65 – 67Combined sources3
Helixi71 – 77Combined sources7
Beta strandi84 – 87Combined sources4
Helixi90 – 92Combined sources3
Helixi97 – 106Combined sources10
Beta strandi110 – 115Combined sources6
Helixi128 – 134Combined sources7
Beta strandi136 – 140Combined sources5
Turni146 – 148Combined sources3
Beta strandi149 – 151Combined sources3
Beta strandi154 – 159Combined sources6
Turni176 – 178Combined sources3
Beta strandi179 – 182Combined sources4
Turni184 – 186Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J9RX-ray2.70A1-194[»]
ProteinModelPortaliQ81JX0
SMRiQ81JX0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81JX0

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni170 – 174Substrate binding5

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiCAGLDQD

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q81JX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLINQNGWI EVICGSMFSG KSEELIRRVR RTQFAKQHAI VFKPCIDNRY
60 70 80 90 100
SEEDVVSHNG LKVKAVPVSA SKDIFKHITE EMDVIAIDEV QFFDGDIVEV
110 120 130 140 150
VQVLANRGYR VIVAGLDQDF RGLPFGQVPQ LMAIAEHVTK LQAVCSACGS
160 170 180 190
PASRTQRLID GEPAAFDDPI ILVGASESYE PRCRHCHAVP TKQR
Length:194
Mass (Da):21,642
Last modified:June 1, 2003 - v1
Checksum:iD2A9B182355D9D13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP29216.1
AE017334 Genomic DNA Translation: AAT34716.1
AE017225 Genomic DNA Translation: AAT57468.1
RefSeqiNP_847730.1, NC_003997.3
WP_000280866.1, NZ_PPES01000006.1
YP_031418.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP29216; AAP29216; BA_5573
AAT34716; AAT34716; GBAA_5573
AAT57468; AAT57468; BAS5179
GeneIDi1085264
2851937
KEGGiban:BA_5573
bar:GBAA_5573
bat:BAS5179
PATRICifig|198094.11.peg.5532

Similar proteinsi

Entry informationi

Entry nameiKITH_BACAN
AccessioniPrimary (citable) accession number: Q81JX0
Secondary accession number(s): Q6HQH0, Q6KJU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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