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Q81JW5 (MURA2_BACAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2
EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase 2
UDP-N-acetylglucosamine enolpyruvyl transferase 2
Short name=EPT 2
Gene names
Name:murA2
Ordered Locus Names:BA_5578, GBAA_5578, BAS5183
OrganismBacillus anthracis [Reference proteome] [HAMAP]
Taxonomic identifier1392 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 HAMAP-Rule MF_00111
PRO_0000231152

Sites

Active site1171Proton donor By similarity

Amino acid modifications

Modified residue11712-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
Q81JW5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 72F8655C2C0C49DA

FASTA42945,866
        10         20         30         40         50         60 
MEKLLIEGGR ALNGTIRVSG AKNSAVALIP ATILADTPVT IGGVPNISDV KMLGDLLEEI 

        70         80         90        100        110        120 
GGRVTYGQEE EMVVDPSNMV AMPLPNGKVK KLRASYYLMG AMLGRFKKAV IGLPGGCHLG 

       130        140        150        160        170        180 
PRPIDQHIKG FEALGAHVTN EQGAIYLRAD ELRGARIYLD VVSVGATINI MLAAVRAKGR 

       190        200        210        220        230        240 
TVIENAAKEP EIIDVATLLT SMGARIKGAG TDVIRIDGVD SLHGCHHTII PDRIEAGTYM 

       250        260        270        280        290        300 
ILGAASGGEV TVDNVIPQHL ESVTAKLREA GVQVETNDDQ ITVNGDRRLK VVDIKTLVYP 

       310        320        330        340        350        360 
GFPTDLQQPF TTLLTKAHGT GVVTDTIYGA RFKHIDELRR MNAQIKVEGR SAIVTGPVLL 

       370        380        390        400        410        420 
QGAKVKASDL RAGAALVIAG LMADGITEVT GLEHIDRGYE NIVDKLKGLG ANIWREQMTK 


QEIEEMKNA

« Hide

References

[1]"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. expand/collapse author list , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames / isolate Porton.
[2]"The complete genome sequence of Bacillus anthracis Ames 'Ancestor'."
Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.
J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames ancestor.
[3]"Complete genome sequence of Bacillus anthracis Sterne."
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sterne.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016879 Genomic DNA. Translation: AAP29221.1.
AE017334 Genomic DNA. Translation: AAT35464.1.
AE017225 Genomic DNA. Translation: AAT57472.1.
RefSeqNP_847735.1. NC_003997.3.
YP_022730.1. NC_007530.2.
YP_031422.1. NC_005945.1.

3D structure databases

ProteinModelPortalQ81JW5.
ModBaseSearch...

Protein-protein interaction databases

STRING198094.BA_5578.

Protocols and materials databases

DNASU1085274.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP29221; AAP29221; BA_5578.
AAT35464; AAT35464; GBAA_5578.
AAT57472; AAT57472; BAS5183.
GeneID1085274.
2821084.
2853124.
KEGGban:BA_5578.
bar:GBAA_5578.
bat:BAS5183.

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMAEHTMLPD.
ProtClustDBPRK12830.

Enzyme and pathway databases

BioCycBANT260799:GJAJ-5258-MONOMER.
BANT261594:GJ7F-5438-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA2_BACAN
AccessionPrimary (citable) accession number: Q81JW5
Secondary accession number(s): Q6HQG6, Q6KIV7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2003
Last modified: May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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