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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2

Gene

murA2

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93UDP-N-acetylglucosamineUniRule annotation1
Active sitei117Proton donorUniRule annotation1
Binding sitei305UDP-N-acetylglucosamineUniRule annotation1
Binding sitei327UDP-N-acetylglucosamine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandPyruvate

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2UniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferase 2UniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferase 2UniRule annotation
Short name:
EPT 2UniRule annotation
Gene namesi
Name:murA2UniRule annotation
Ordered Locus Names:BA_5578, GBAA_5578, BAS5183
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002311521 – 429UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2Add BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1172-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS5183

Structurei

3D structure databases

ProteinModelPortaliQ81JW5
SMRiQ81JW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 23Phosphoenolpyruvate bindingUniRule annotation2
Regioni122 – 126UDP-N-acetylglucosamine bindingUniRule annotation5

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDF Bacteria
COG0766 LUCA
HOGENOMiHOG000075602
KOiK00790
OMAiCRFGQRN

Family and domain databases

CDDicd01555 UdpNAET, 1 hit
Gene3Di3.65.10.10, 3 hits
HAMAPiMF_00111 MurA, 1 hit
InterProiView protein in InterPro
IPR001986 Enolpyruvate_Tfrase_dom
IPR036968 Enolpyruvate_Tfrase_sf
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR005750 UDP_GlcNAc_COvinyl_MurA
PfamiView protein in Pfam
PF00275 EPSP_synthase, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR01072 murA, 1 hit

Sequencei

Sequence statusi: Complete.

Q81JW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLLIEGGR ALNGTIRVSG AKNSAVALIP ATILADTPVT IGGVPNISDV
60 70 80 90 100
KMLGDLLEEI GGRVTYGQEE EMVVDPSNMV AMPLPNGKVK KLRASYYLMG
110 120 130 140 150
AMLGRFKKAV IGLPGGCHLG PRPIDQHIKG FEALGAHVTN EQGAIYLRAD
160 170 180 190 200
ELRGARIYLD VVSVGATINI MLAAVRAKGR TVIENAAKEP EIIDVATLLT
210 220 230 240 250
SMGARIKGAG TDVIRIDGVD SLHGCHHTII PDRIEAGTYM ILGAASGGEV
260 270 280 290 300
TVDNVIPQHL ESVTAKLREA GVQVETNDDQ ITVNGDRRLK VVDIKTLVYP
310 320 330 340 350
GFPTDLQQPF TTLLTKAHGT GVVTDTIYGA RFKHIDELRR MNAQIKVEGR
360 370 380 390 400
SAIVTGPVLL QGAKVKASDL RAGAALVIAG LMADGITEVT GLEHIDRGYE
410 420
NIVDKLKGLG ANIWREQMTK QEIEEMKNA
Length:429
Mass (Da):45,866
Last modified:June 1, 2003 - v1
Checksum:i72F8655C2C0C49DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP29221.1
AE017334 Genomic DNA Translation: AAT35464.1
AE017225 Genomic DNA Translation: AAT57472.1
RefSeqiNP_847735.1, NC_003997.3
WP_000413260.1, NZ_NVLR01000033.1
YP_031422.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP29221; AAP29221; BA_5578
AAT35464; AAT35464; GBAA_5578
AAT57472; AAT57472; BAS5183
GeneIDi1085274
2853124
KEGGiban:BA_5578
bar:GBAA_5578
bat:BAS5183
PATRICifig|198094.11.peg.5536

Similar proteinsi

Entry informationi

Entry nameiMURA2_BACAN
AccessioniPrimary (citable) accession number: Q81JW5
Secondary accession number(s): Q6HQG6, Q6KIV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health