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Q81JT1

- SPEB_BACAN

UniProt

Q81JT1 - SPEB_BACAN

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Protein
Agmatinase
Gene
speB, BA_5617, GBAA_5617, BAS5218
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine By similarity.

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Manganese By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi112 – 1121Manganese By similarity
Metal bindingi135 – 1351Manganese By similarity
Metal bindingi137 – 1371Manganese By similarity
Metal bindingi139 – 1391Manganese By similarity
Metal bindingi216 – 2161Manganese By similarity
Metal bindingi218 – 2181Manganese By similarity

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-5293-MONOMER.
BANT261594:GJ7F-5474-MONOMER.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
Ordered Locus Names:BA_5617, GBAA_5617, BAS5218
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Agmatinase
PRO_0000173725Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_5617.

Structurei

3D structure databases

ProteinModelPortaliQ81JT1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204321.
KOiK01480.
OMAiRWAPDAM.
OrthoDBiEOG6R2GW5.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81JT1-1 [UniParc]FASTAAdd to Basket

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MRFDEAYSGK VFIKSHPSFE ESEVVIYGMP MDWTVSYRPG SRFGPARIRE    50
VSIGLEEYSP YLDRELEEVK YFDAGDIPLP FGNAQRSLDM IEEYVSKLLD 100
AGKFPLGLGG EHLVSWPIFK AMAKKYPDLA IIHMDAHTDL RESYEGEPLS 150
HSTPIRKVCD LIGPENVYSF GIRSGMKEEF EWAKEVGMNL YKFDVLEPLK 200
EVLPKLEGRP VYVTIDIDVL DPAHAPGTGT LEAGGITSKE LLDSIVAIAN 250
SNINVVGADL VEVAPVYDHS DQTPVAASKF VREMLLGWVK 290
Length:290
Mass (Da):32,390
Last modified:June 1, 2003 - v1
Checksum:i6F2F39ED33E38DE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP29255.1.
AE017334 Genomic DNA. Translation: AAT34764.1.
AE017225 Genomic DNA. Translation: AAT57507.1.
RefSeqiNP_847769.1. NC_003997.3.
YP_022289.1. NC_007530.2.
YP_031457.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP29255; AAP29255; BA_5617.
AAT34764; AAT34764; GBAA_5617.
AAT57507; AAT57507; BAS5218.
GeneIDi1085325.
2817842.
2848265.
KEGGiban:BA_5617.
bar:GBAA_5617.
bat:BAS5218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP29255.1 .
AE017334 Genomic DNA. Translation: AAT34764.1 .
AE017225 Genomic DNA. Translation: AAT57507.1 .
RefSeqi NP_847769.1. NC_003997.3.
YP_022289.1. NC_007530.2.
YP_031457.1. NC_005945.1.

3D structure databases

ProteinModelPortali Q81JT1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_5617.

Protocols and materials databases

DNASUi 1085325.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP29255 ; AAP29255 ; BA_5617 .
AAT34764 ; AAT34764 ; GBAA_5617 .
AAT57507 ; AAT57507 ; BAS5218 .
GeneIDi 1085325.
2817842.
2848265.
KEGGi ban:BA_5617.
bar:GBAA_5617.
bat:BAS5218.

Phylogenomic databases

eggNOGi COG0010.
HOGENOMi HOG000204321.
KOi K01480.
OMAi RWAPDAM.
OrthoDBi EOG6R2GW5.

Enzyme and pathway databases

UniPathwayi UPA00534 ; UER00287 .
BioCyci BANT260799:GJAJ-5293-MONOMER.
BANT261594:GJ7F-5474-MONOMER.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
InterProi IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
TIGRFAMsi TIGR01230. agmatinase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiSPEB_BACAN
AccessioniPrimary (citable) accession number: Q81JT1
Secondary accession number(s): Q6HQD1, Q6KJQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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