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Protein

Agmatinase

Gene

speB

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.By similarity

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Mn2+PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi112 – 1121ManganesePROSITE-ProRule annotation
Metal bindingi135 – 1351ManganesePROSITE-ProRule annotation
Metal bindingi137 – 1371ManganesePROSITE-ProRule annotation
Metal bindingi139 – 1391ManganesePROSITE-ProRule annotation
Metal bindingi216 – 2161ManganesePROSITE-ProRule annotation
Metal bindingi218 – 2181ManganesePROSITE-ProRule annotation

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-5293-MONOMER.
BANT261594:GJ7F-5474-MONOMER.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
Ordered Locus Names:BA_5617, GBAA_5617, BAS5218
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000005639 Componenti: Chromosome UP000000594 Componenti: Chromosome UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290AgmatinasePRO_0000173725Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_5617.

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204321.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81JT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFDEAYSGK VFIKSHPSFE ESEVVIYGMP MDWTVSYRPG SRFGPARIRE
60 70 80 90 100
VSIGLEEYSP YLDRELEEVK YFDAGDIPLP FGNAQRSLDM IEEYVSKLLD
110 120 130 140 150
AGKFPLGLGG EHLVSWPIFK AMAKKYPDLA IIHMDAHTDL RESYEGEPLS
160 170 180 190 200
HSTPIRKVCD LIGPENVYSF GIRSGMKEEF EWAKEVGMNL YKFDVLEPLK
210 220 230 240 250
EVLPKLEGRP VYVTIDIDVL DPAHAPGTGT LEAGGITSKE LLDSIVAIAN
260 270 280 290
SNINVVGADL VEVAPVYDHS DQTPVAASKF VREMLLGWVK
Length:290
Mass (Da):32,390
Last modified:June 1, 2003 - v1
Checksum:i6F2F39ED33E38DE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29255.1.
AE017334 Genomic DNA. Translation: AAT34764.1.
AE017225 Genomic DNA. Translation: AAT57507.1.
RefSeqiNP_847769.1. NC_003997.3.
YP_022289.1. NC_007530.2.
YP_031457.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP29255; AAP29255; BA_5617.
AAT34764; AAT34764; GBAA_5617.
AAT57507; AAT57507; BAS5218.
GeneIDi1085325.
2848265.
KEGGiban:BA_5617.
bar:GBAA_5617.
bat:BAS5218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29255.1.
AE017334 Genomic DNA. Translation: AAT34764.1.
AE017225 Genomic DNA. Translation: AAT57507.1.
RefSeqiNP_847769.1. NC_003997.3.
YP_022289.1. NC_007530.2.
YP_031457.1. NC_005945.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_5617.

Protocols and materials databases

DNASUi1085325.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP29255; AAP29255; BA_5617.
AAT34764; AAT34764; GBAA_5617.
AAT57507; AAT57507; BAS5218.
GeneIDi1085325.
2848265.
KEGGiban:BA_5617.
bar:GBAA_5617.
bat:BAS5218.

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204321.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.

Enzyme and pathway databases

UniPathwayiUPA00534; UER00287.
BioCyciBANT260799:GJAJ-5293-MONOMER.
BANT261594:GJ7F-5474-MONOMER.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiSPEB_BACAN
AccessioniPrimary (citable) accession number: Q81JT1
Secondary accession number(s): Q6HQD1, Q6KJQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.