Q81JK8 (SODM2_BACAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Mn] 2
EC=1.15.1.1

Gene names

Name:	sodA2
Synonyms:	sodA-2
Ordered Locus Names:	BA_5696, GBAA_5696, BAS5300

Organism

Bacillus anthracis [Reference proteome] [HAMAP]

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 manganese ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 208

208

Superoxide dismutase [Mn] 2

PRO_0000160013

Sites

Metal binding

28

1

Manganese By similarity

Metal binding

83

1

Manganese By similarity

Metal binding

165

1

Manganese By similarity

Metal binding

169

1

Manganese By similarity

Secondary structure

1

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208

Helix Strand Turn

Details...

Turn

13 – 19

7

Helix

22 – 30

9

Helix

32 – 44

13

Helix

48 – 50

3

Helix

55 – 60

6

Helix

62 – 64

3

Turn

67 – 69

3

Helix

70 – 88

19

Helix

100 – 110

11

Helix

113 – 125

13

Beta strand

129 – 138

10

Beta strand

141 – 148

8

Helix

153 – 156

4

Beta strand

159 – 165

7

Helix

168 – 170

3

Helix

172 – 175

4

Helix

179 – 186

8

Helix

187 – 189

3

Helix

192 – 202

11

Sequences

	Sequence		Length	Mass (Da)
	Q81JK8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 870D8FF1C721FD73	FASTA	208	24,023
	10 20 30 40 50 60 MSSFQLPKLS YDYDELEPYI DSNTLSIHHG KHHATYVNNL NAALENYSEL HNKSLEELLC 70 80 90 100 110 120 NLETLPKEIV TAVRNNGGGH YCHSLFWEVM SPRGGGEPNG DVAKVIDYYF NTFDNLKDQL 130 140 150 160 170 180 SKAAISRFGS GYGWLVLDGE ELSVMSTPNQ DTPLQEGKIP LLVIDVWEHA YYLKYQNRRP 190 200 EFVTNWWHTV NWDRVNEKYL QAIQSQKH

References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"The complete genome sequence of Bacillus anthracis Ames 'Ancestor'." Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A. J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016879 Genomic DNA. Translation: AAP29328.1.
AE017334 Genomic DNA. Translation: AAT34855.1.
AE017225 Genomic DNA. Translation: AAT57587.1.

RefSeq

NP_847842.1. NC_003997.3.
YP_022380.1. NC_007530.2.
YP_031537.1. NC_005945.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XRE	X-ray	1.80	A/B	1-208	[»]

ProteinModelPortal

Q81JK8.

SMR

Q81JK8. Positions 3-203.

ModBase

Search...

Protein-protein interaction databases

STRING

198094.BA_5696.

Protocols and materials databases

DNASU

1085438.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAP29328; AAP29328; BA_5696.
AAT34855; AAT34855; GBAA_5696.
AAT57587; AAT57587; BAS5300.

GeneID

1085438.
2817089.
2853067.

KEGG

ban:BA_5696.
bar:GBAA_5696.
bat:BAS5300.

Phylogenomic databases

eggNOG

COG0605.

HOGENOM

HOG000013583.

KO

K04564.

OMA

NIWNVIN.

ProtClustDB

CLSK917710.

Enzyme and pathway databases

BioCyc

BANT260799:GJAJ-5373-MONOMER.
BANT261594:GJ7F-5549-MONOMER.

Family and domain databases

InterPro

IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]

PANTHER

PTHR11404. PTHR11404. 1 hit.

Pfam

PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000349. SODismutase. 1 hit.

PRINTS

PR01703. MNSODISMTASE.

SUPFAM

SSF46609. SODismutase. 1 hit.
SSF54719. SODismutase. 1 hit.

PROSITE

PS00088. SOD_MN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q81JK8.

Entry information

Entry name

SODM2_BACAN

Accession

Primary (citable) accession number: Q81JK8
Secondary accession number(s): Q6HQ51, Q6KJJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program