Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Superoxide dismutase [Mn] 2

Gene

sodA2

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281ManganeseBy similarity
Metal bindingi83 – 831ManganeseBy similarity
Metal bindingi165 – 1651ManganeseBy similarity
Metal bindingi169 – 1691ManganeseBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciANTHRA:SODA-2-MONOMER.
BANT260799:GJAJ-5373-MONOMER.
BANT261594:GJ7F-5549-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] 2 (EC:1.15.1.1)
Gene namesi
Name:sodA2
Synonyms:sodA-2
Ordered Locus Names:BA_5696, GBAA_5696, BAS5300
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000005639 Componenti: Chromosome UP000000594 Componenti: Chromosome UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Superoxide dismutase [Mn] 2PRO_0000160013Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198094.BA_5696.

Structurei

Secondary structure

1
208
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni13 – 197Combined sources
Helixi22 – 309Combined sources
Helixi32 – 4413Combined sources
Helixi48 – 503Combined sources
Helixi55 – 606Combined sources
Helixi62 – 643Combined sources
Turni67 – 693Combined sources
Helixi70 – 8819Combined sources
Helixi100 – 11011Combined sources
Helixi113 – 12513Combined sources
Beta strandi129 – 13810Combined sources
Beta strandi141 – 1488Combined sources
Helixi153 – 1564Combined sources
Beta strandi159 – 1657Combined sources
Helixi168 – 1703Combined sources
Helixi172 – 1754Combined sources
Helixi179 – 1868Combined sources
Helixi187 – 1893Combined sources
Helixi192 – 20211Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XREX-ray1.80A/B1-208[»]
SMRiQ81JK8. Positions 3-203.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81JK8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013583.
KOiK04564.
OMAiVNWSEIN.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81JK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFQLPKLS YDYDELEPYI DSNTLSIHHG KHHATYVNNL NAALENYSEL
60 70 80 90 100
HNKSLEELLC NLETLPKEIV TAVRNNGGGH YCHSLFWEVM SPRGGGEPNG
110 120 130 140 150
DVAKVIDYYF NTFDNLKDQL SKAAISRFGS GYGWLVLDGE ELSVMSTPNQ
160 170 180 190 200
DTPLQEGKIP LLVIDVWEHA YYLKYQNRRP EFVTNWWHTV NWDRVNEKYL

QAIQSQKH
Length:208
Mass (Da):24,023
Last modified:May 31, 2003 - v1
Checksum:i870D8FF1C721FD73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29328.1.
AE017334 Genomic DNA. Translation: AAT34855.1.
AE017225 Genomic DNA. Translation: AAT57587.1.
RefSeqiNP_847842.1. NC_003997.3.
YP_022380.1. NC_007530.2.
YP_031537.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP29328; AAP29328; BA_5696.
AAT34855; AAT34855; GBAA_5696.
AAT57587; AAT57587; BAS5300.
GeneIDi1085438.
2853067.
KEGGiban:BA_5696.
bar:GBAA_5696.
bat:BAS5300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29328.1.
AE017334 Genomic DNA. Translation: AAT34855.1.
AE017225 Genomic DNA. Translation: AAT57587.1.
RefSeqiNP_847842.1. NC_003997.3.
YP_022380.1. NC_007530.2.
YP_031537.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XREX-ray1.80A/B1-208[»]
SMRiQ81JK8. Positions 3-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_5696.

Protocols and materials databases

DNASUi1085438.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP29328; AAP29328; BA_5696.
AAT34855; AAT34855; GBAA_5696.
AAT57587; AAT57587; BAS5300.
GeneIDi1085438.
2853067.
KEGGiban:BA_5696.
bar:GBAA_5696.
bat:BAS5300.

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013583.
KOiK04564.
OMAiVNWSEIN.
OrthoDBiEOG63NMNT.

Enzyme and pathway databases

BioCyciANTHRA:SODA-2-MONOMER.
BANT260799:GJAJ-5373-MONOMER.
BANT261594:GJ7F-5549-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81JK8.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiSODM2_BACAN
AccessioniPrimary (citable) accession number: Q81JK8
Secondary accession number(s): Q6HQ51, Q6KJJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 28, 2003
Last sequence update: May 31, 2003
Last modified: March 31, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.