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Q81JK8

- SODM2_BACAN

UniProt

Q81JK8 - SODM2_BACAN

Protein

Superoxide dismutase [Mn] 2

Gene

sodA2

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281ManganeseBy similarity
    Metal bindingi83 – 831ManganeseBy similarity
    Metal bindingi165 – 1651ManganeseBy similarity
    Metal bindingi169 – 1691ManganeseBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciANTHRA:SODA-2-MONOMER.
    BANT260799:GJAJ-5373-MONOMER.
    BANT261594:GJ7F-5549-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn] 2 (EC:1.15.1.1)
    Gene namesi
    Name:sodA2
    Synonyms:sodA-2
    Ordered Locus Names:BA_5696, GBAA_5696, BAS5300
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Superoxide dismutase [Mn] 2PRO_0000160013Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi198094.BA_5696.

    Structurei

    Secondary structure

    1
    208
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni13 – 197
    Helixi22 – 309
    Helixi32 – 4413
    Helixi48 – 503
    Helixi55 – 606
    Helixi62 – 643
    Turni67 – 693
    Helixi70 – 8819
    Helixi100 – 11011
    Helixi113 – 12513
    Beta strandi129 – 13810
    Beta strandi141 – 1488
    Helixi153 – 1564
    Beta strandi159 – 1657
    Helixi168 – 1703
    Helixi172 – 1754
    Helixi179 – 1868
    Helixi187 – 1893
    Helixi192 – 20211

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XREX-ray1.80A/B1-208[»]
    ProteinModelPortaliQ81JK8.
    SMRiQ81JK8. Positions 3-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ81JK8.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0605.
    HOGENOMiHOG000013583.
    KOiK04564.
    OMAiKIGIFNN.
    OrthoDBiEOG63NMNT.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81JK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSFQLPKLS YDYDELEPYI DSNTLSIHHG KHHATYVNNL NAALENYSEL    50
    HNKSLEELLC NLETLPKEIV TAVRNNGGGH YCHSLFWEVM SPRGGGEPNG 100
    DVAKVIDYYF NTFDNLKDQL SKAAISRFGS GYGWLVLDGE ELSVMSTPNQ 150
    DTPLQEGKIP LLVIDVWEHA YYLKYQNRRP EFVTNWWHTV NWDRVNEKYL 200
    QAIQSQKH 208
    Length:208
    Mass (Da):24,023
    Last modified:June 1, 2003 - v1
    Checksum:i870D8FF1C721FD73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP29328.1.
    AE017334 Genomic DNA. Translation: AAT34855.1.
    AE017225 Genomic DNA. Translation: AAT57587.1.
    RefSeqiNP_847842.1. NC_003997.3.
    YP_022380.1. NC_007530.2.
    YP_031537.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP29328; AAP29328; BA_5696.
    AAT34855; AAT34855; GBAA_5696.
    AAT57587; AAT57587; BAS5300.
    GeneIDi1085438.
    2817089.
    2853067.
    KEGGiban:BA_5696.
    bar:GBAA_5696.
    bat:BAS5300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP29328.1 .
    AE017334 Genomic DNA. Translation: AAT34855.1 .
    AE017225 Genomic DNA. Translation: AAT57587.1 .
    RefSeqi NP_847842.1. NC_003997.3.
    YP_022380.1. NC_007530.2.
    YP_031537.1. NC_005945.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XRE X-ray 1.80 A/B 1-208 [» ]
    ProteinModelPortali Q81JK8.
    SMRi Q81JK8. Positions 3-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_5696.

    Protocols and materials databases

    DNASUi 1085438.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP29328 ; AAP29328 ; BA_5696 .
    AAT34855 ; AAT34855 ; GBAA_5696 .
    AAT57587 ; AAT57587 ; BAS5300 .
    GeneIDi 1085438.
    2817089.
    2853067.
    KEGGi ban:BA_5696.
    bar:GBAA_5696.
    bat:BAS5300.

    Phylogenomic databases

    eggNOGi COG0605.
    HOGENOMi HOG000013583.
    KOi K04564.
    OMAi KIGIFNN.
    OrthoDBi EOG63NMNT.

    Enzyme and pathway databases

    BioCyci ANTHRA:SODA-2-MONOMER.
    BANT260799:GJAJ-5373-MONOMER.
    BANT261594:GJ7F-5549-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q81JK8.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiSODM2_BACAN
    AccessioniPrimary (citable) accession number: Q81JK8
    Secondary accession number(s): Q6HQ51, Q6KJJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3