Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q81JJ9

- GUAC_BACAN

UniProt

Q81JJ9 - GUAC_BACAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GMP reductase

Gene

guaC

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei175 – 1751Thioimidate intermediateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi204 – 22724NADPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. dihydroorotate dehydrogenase activity Source: InterPro
  2. GMP reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciANTHRA:GUAC-MONOMER.
BANT260799:GJAJ-5382-MONOMER.
BANT261594:GJ7F-5558-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductaseUniRule annotation (EC:1.7.1.7UniRule annotation)
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductaseUniRule annotation
Short name:
Guanosine monophosphate reductaseUniRule annotation
Gene namesi
Name:guaCUniRule annotation
Ordered Locus Names:BA_5705, GBAA_5705, BAS5309
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. GMP reductase complex Source: UniProtKB-EC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327GMP reductasePRO_0000093746Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_5705.

Structurei

Secondary structure

1
327
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 93
Beta strandi10 – 123
Helixi22 – 243
Beta strandi29 – 313
Beta strandi34 – 429
Turni46 – 483
Helixi51 – 599
Helixi71 – 733
Helixi74 – 8310
Beta strandi89 – 924
Helixi96 – 10712
Beta strandi113 – 1186
Helixi125 – 13713
Beta strandi141 – 1488
Helixi151 – 16010
Beta strandi163 – 1675
Helixi176 – 1816
Helixi189 – 19810
Beta strandi204 – 2085
Helixi214 – 2218
Beta strandi225 – 2306
Helixi231 – 2333
Beta strandi239 – 2413
Beta strandi273 – 2775
Helixi282 – 29918
Beta strandi302 – 3043
Helixi305 – 3106
Beta strandi313 – 3153

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YPFX-ray1.80A/B1-327[»]
2A1YX-ray2.27A1-327[»]
ProteinModelPortaliQ81JJ9.
SMRiQ81JJ9. Positions 1-321.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81JJ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0516.
HOGENOMiHOG000165753.
KOiK00364.
OMAiKEEYLFI.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01511. GMP_reduct_type2.
InterProiIPR013785. Aldolase_TIM.
IPR001295. Dihydroorotate_DH_CS.
IPR005994. GuaC_type_2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsiTIGR01306. GMP_reduct_2. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81JJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNVFDYEDI QLIPAKCIVN SRSECDTTVT LGKHKFKLPV VPANMQTIID
60 70 80 90 100
ERIATYLAEN NYFYIMHRFQ PEKRISFIRD MQSRGLIASI SVGVKEDEYE
110 120 130 140 150
FVQQLAAEHL TPEYITIDIA HGHSNAVINM IQHIKKHLPE SFVIAGNVGT
160 170 180 190 200
PEAVRELENA GADATKVGIG PGKVCITKIK TGFGTGGWQL AALRWCAKAA
210 220 230 240 250
SKPIIADGGI RTNGDVAKSI RFGATMVMIG SLFAGHEESP GETIEKDGKL
260 270 280 290 300
YKEYFGSASE FQKGEKKNVE GKKMFVEHKG SLEDTLIEME QDLQSSISYA
310 320
GGTKLDSIRT VDYVVVKNSI FNGDKVY
Length:327
Mass (Da):36,076
Last modified:June 1, 2003 - v1
Checksum:i8006FDFA6A5F2E78
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP29337.1.
AE017334 Genomic DNA. Translation: AAT34865.1.
AE017225 Genomic DNA. Translation: AAT57596.1.
RefSeqiNP_847851.1. NC_003997.3.
WP_017651043.1. NZ_JHDR01000004.1.
YP_022390.1. NC_007530.2.
YP_031546.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP29337; AAP29337; BA_5705.
AAT34865; AAT34865; GBAA_5705.
AAT57596; AAT57596; BAS5309.
GeneIDi1085456.
2816139.
2852911.
KEGGiban:BA_5705.
bar:GBAA_5705.
bat:BAS5309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP29337.1 .
AE017334 Genomic DNA. Translation: AAT34865.1 .
AE017225 Genomic DNA. Translation: AAT57596.1 .
RefSeqi NP_847851.1. NC_003997.3.
WP_017651043.1. NZ_JHDR01000004.1.
YP_022390.1. NC_007530.2.
YP_031546.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YPF X-ray 1.80 A/B 1-327 [» ]
2A1Y X-ray 2.27 A 1-327 [» ]
ProteinModelPortali Q81JJ9.
SMRi Q81JJ9. Positions 1-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_5705.

Protocols and materials databases

DNASUi 1085456.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP29337 ; AAP29337 ; BA_5705 .
AAT34865 ; AAT34865 ; GBAA_5705 .
AAT57596 ; AAT57596 ; BAS5309 .
GeneIDi 1085456.
2816139.
2852911.
KEGGi ban:BA_5705.
bar:GBAA_5705.
bat:BAS5309.

Phylogenomic databases

eggNOGi COG0516.
HOGENOMi HOG000165753.
KOi K00364.
OMAi KEEYLFI.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

BioCyci ANTHRA:GUAC-MONOMER.
BANT260799:GJAJ-5382-MONOMER.
BANT261594:GJ7F-5558-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q81JJ9.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01511. GMP_reduct_type2.
InterProi IPR013785. Aldolase_TIM.
IPR001295. Dihydroorotate_DH_CS.
IPR005994. GuaC_type_2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsi TIGR01306. GMP_reduct_2. 1 hit.
PROSITEi PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiGUAC_BACAN
AccessioniPrimary (citable) accession number: Q81JJ9
Secondary accession number(s): Q6HQ42, Q6KJI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3