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Q81JJ9

- GUAC_BACAN

UniProt

Q81JJ9 - GUAC_BACAN

Protein

GMP reductase

Gene

guaC

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

    Catalytic activityi

    Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei175 – 1751Thioimidate intermediateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi204 – 22724NADPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. dihydroorotate dehydrogenase activity Source: InterPro
    2. GMP reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciANTHRA:GUAC-MONOMER.
    BANT260799:GJAJ-5382-MONOMER.
    BANT261594:GJ7F-5558-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GMP reductaseUniRule annotation (EC:1.7.1.7UniRule annotation)
    Alternative name(s):
    Guanosine 5'-monophosphate oxidoreductaseUniRule annotation
    Short name:
    Guanosine monophosphate reductaseUniRule annotation
    Gene namesi
    Name:guaCUniRule annotation
    Ordered Locus Names:BA_5705, GBAA_5705, BAS5309
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. GMP reductase complex Source: UniProtKB-EC

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327GMP reductasePRO_0000093746Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198094.BA_5705.

    Structurei

    Secondary structure

    1
    327
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 93
    Beta strandi10 – 123
    Helixi22 – 243
    Beta strandi29 – 313
    Beta strandi34 – 429
    Turni46 – 483
    Helixi51 – 599
    Helixi71 – 733
    Helixi74 – 8310
    Beta strandi89 – 924
    Helixi96 – 10712
    Beta strandi113 – 1186
    Helixi125 – 13713
    Beta strandi141 – 1488
    Helixi151 – 16010
    Beta strandi163 – 1675
    Helixi176 – 1816
    Helixi189 – 19810
    Beta strandi204 – 2085
    Helixi214 – 2218
    Beta strandi225 – 2306
    Helixi231 – 2333
    Beta strandi239 – 2413
    Beta strandi273 – 2775
    Helixi282 – 29918
    Beta strandi302 – 3043
    Helixi305 – 3106
    Beta strandi313 – 3153

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YPFX-ray1.80A/B1-327[»]
    2A1YX-ray2.27A1-327[»]
    ProteinModelPortaliQ81JJ9.
    SMRiQ81JJ9. Positions 1-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ81JJ9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0516.
    HOGENOMiHOG000165753.
    KOiK00364.
    OMAiKEEYLFI.
    OrthoDBiEOG6GTZPV.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01511. GMP_reduct_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR001295. Dihydroorotate_DH_CS.
    IPR005994. GuaC_type_2.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view]
    PfamiPF00478. IMPDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036500. GMP_red_Firmic. 1 hit.
    TIGRFAMsiTIGR01306. GMP_reduct_2. 1 hit.
    PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81JJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNVFDYEDI QLIPAKCIVN SRSECDTTVT LGKHKFKLPV VPANMQTIID    50
    ERIATYLAEN NYFYIMHRFQ PEKRISFIRD MQSRGLIASI SVGVKEDEYE 100
    FVQQLAAEHL TPEYITIDIA HGHSNAVINM IQHIKKHLPE SFVIAGNVGT 150
    PEAVRELENA GADATKVGIG PGKVCITKIK TGFGTGGWQL AALRWCAKAA 200
    SKPIIADGGI RTNGDVAKSI RFGATMVMIG SLFAGHEESP GETIEKDGKL 250
    YKEYFGSASE FQKGEKKNVE GKKMFVEHKG SLEDTLIEME QDLQSSISYA 300
    GGTKLDSIRT VDYVVVKNSI FNGDKVY 327
    Length:327
    Mass (Da):36,076
    Last modified:June 1, 2003 - v1
    Checksum:i8006FDFA6A5F2E78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP29337.1.
    AE017334 Genomic DNA. Translation: AAT34865.1.
    AE017225 Genomic DNA. Translation: AAT57596.1.
    RefSeqiNP_847851.1. NC_003997.3.
    YP_022390.1. NC_007530.2.
    YP_031546.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP29337; AAP29337; BA_5705.
    AAT34865; AAT34865; GBAA_5705.
    AAT57596; AAT57596; BAS5309.
    GeneIDi1085456.
    2816139.
    2852911.
    KEGGiban:BA_5705.
    bar:GBAA_5705.
    bat:BAS5309.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP29337.1 .
    AE017334 Genomic DNA. Translation: AAT34865.1 .
    AE017225 Genomic DNA. Translation: AAT57596.1 .
    RefSeqi NP_847851.1. NC_003997.3.
    YP_022390.1. NC_007530.2.
    YP_031546.1. NC_005945.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YPF X-ray 1.80 A/B 1-327 [» ]
    2A1Y X-ray 2.27 A 1-327 [» ]
    ProteinModelPortali Q81JJ9.
    SMRi Q81JJ9. Positions 1-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_5705.

    Protocols and materials databases

    DNASUi 1085456.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP29337 ; AAP29337 ; BA_5705 .
    AAT34865 ; AAT34865 ; GBAA_5705 .
    AAT57596 ; AAT57596 ; BAS5309 .
    GeneIDi 1085456.
    2816139.
    2852911.
    KEGGi ban:BA_5705.
    bar:GBAA_5705.
    bat:BAS5309.

    Phylogenomic databases

    eggNOGi COG0516.
    HOGENOMi HOG000165753.
    KOi K00364.
    OMAi KEEYLFI.
    OrthoDBi EOG6GTZPV.

    Enzyme and pathway databases

    BioCyci ANTHRA:GUAC-MONOMER.
    BANT260799:GJAJ-5382-MONOMER.
    BANT261594:GJ7F-5558-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q81JJ9.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01511. GMP_reduct_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR001295. Dihydroorotate_DH_CS.
    IPR005994. GuaC_type_2.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view ]
    Pfami PF00478. IMPDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036500. GMP_red_Firmic. 1 hit.
    TIGRFAMsi TIGR01306. GMP_reduct_2. 1 hit.
    PROSITEi PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiGUAC_BACAN
    AccessioniPrimary (citable) accession number: Q81JJ9
    Secondary accession number(s): Q6HQ42, Q6KJI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3