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Protein

GMP reductase

Gene

guaC

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175Thioimidate intermediateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 227NADPUniRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciANTHRA:GUAC-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductaseUniRule annotation (EC:1.7.1.7UniRule annotation)
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductaseUniRule annotation
Short name:
Guanosine monophosphate reductaseUniRule annotation
Gene namesi
Name:guaCUniRule annotation
Ordered Locus Names:BA_5705, GBAA_5705, BAS5309
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000937461 – 327GMP reductaseAdd BLAST327

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_5705.

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Beta strandi10 – 12Combined sources3
Helixi22 – 24Combined sources3
Beta strandi29 – 31Combined sources3
Beta strandi34 – 42Combined sources9
Turni46 – 48Combined sources3
Helixi51 – 59Combined sources9
Helixi71 – 73Combined sources3
Helixi74 – 83Combined sources10
Beta strandi89 – 92Combined sources4
Helixi96 – 107Combined sources12
Beta strandi113 – 118Combined sources6
Helixi125 – 137Combined sources13
Beta strandi141 – 148Combined sources8
Helixi151 – 160Combined sources10
Beta strandi163 – 167Combined sources5
Helixi176 – 181Combined sources6
Helixi189 – 198Combined sources10
Beta strandi204 – 208Combined sources5
Helixi214 – 221Combined sources8
Beta strandi225 – 230Combined sources6
Helixi231 – 233Combined sources3
Beta strandi239 – 241Combined sources3
Beta strandi273 – 277Combined sources5
Helixi282 – 299Combined sources18
Beta strandi302 – 304Combined sources3
Helixi305 – 310Combined sources6
Beta strandi313 – 315Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YPFX-ray1.80A/B1-327[»]
2A1YX-ray2.27A1-327[»]
ProteinModelPortaliQ81JJ9.
SMRiQ81JJ9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81JJ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0516. LUCA.
HOGENOMiHOG000165753.
KOiK00364.
OMAiAYKEYFG.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01511. GMP_reduct_type2. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001295. Dihydroorotate_DH_CS.
IPR005994. GuaC_type_2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsiTIGR01306. GMP_reduct_2. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81JJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNVFDYEDI QLIPAKCIVN SRSECDTTVT LGKHKFKLPV VPANMQTIID
60 70 80 90 100
ERIATYLAEN NYFYIMHRFQ PEKRISFIRD MQSRGLIASI SVGVKEDEYE
110 120 130 140 150
FVQQLAAEHL TPEYITIDIA HGHSNAVINM IQHIKKHLPE SFVIAGNVGT
160 170 180 190 200
PEAVRELENA GADATKVGIG PGKVCITKIK TGFGTGGWQL AALRWCAKAA
210 220 230 240 250
SKPIIADGGI RTNGDVAKSI RFGATMVMIG SLFAGHEESP GETIEKDGKL
260 270 280 290 300
YKEYFGSASE FQKGEKKNVE GKKMFVEHKG SLEDTLIEME QDLQSSISYA
310 320
GGTKLDSIRT VDYVVVKNSI FNGDKVY
Length:327
Mass (Da):36,076
Last modified:June 1, 2003 - v1
Checksum:i8006FDFA6A5F2E78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29337.1.
AE017334 Genomic DNA. Translation: AAT34865.1.
AE017225 Genomic DNA. Translation: AAT57596.1.
RefSeqiNP_847851.1. NC_003997.3.
WP_000528705.1. NZ_LHUO01000009.1.
YP_031546.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP29337; AAP29337; BA_5705.
AAT34865; AAT34865; GBAA_5705.
AAT57596; AAT57596; BAS5309.
GeneIDi1085456.
2852911.
KEGGiban:BA_5705.
bar:GBAA_5705.
bat:BAS5309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP29337.1.
AE017334 Genomic DNA. Translation: AAT34865.1.
AE017225 Genomic DNA. Translation: AAT57596.1.
RefSeqiNP_847851.1. NC_003997.3.
WP_000528705.1. NZ_LHUO01000009.1.
YP_031546.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YPFX-ray1.80A/B1-327[»]
2A1YX-ray2.27A1-327[»]
ProteinModelPortaliQ81JJ9.
SMRiQ81JJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_5705.

Protocols and materials databases

DNASUi1085456.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP29337; AAP29337; BA_5705.
AAT34865; AAT34865; GBAA_5705.
AAT57596; AAT57596; BAS5309.
GeneIDi1085456.
2852911.
KEGGiban:BA_5705.
bar:GBAA_5705.
bat:BAS5309.

Phylogenomic databases

eggNOGiCOG0516. LUCA.
HOGENOMiHOG000165753.
KOiK00364.
OMAiAYKEYFG.

Enzyme and pathway databases

BioCyciANTHRA:GUAC-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81JJ9.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01511. GMP_reduct_type2. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001295. Dihydroorotate_DH_CS.
IPR005994. GuaC_type_2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsiTIGR01306. GMP_reduct_2. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUAC_BACAN
AccessioniPrimary (citable) accession number: Q81JJ9
Secondary accession number(s): Q6HQ42, Q6KJI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.