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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 1

Gene

murG1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 1UniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 1UniRule annotation
Gene namesi
Name:murG1UniRule annotation
Synonyms:murG-1
Ordered Locus Names:BA_4049, GBAA_4049, BAS3761
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001091381 – 364UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 1Add BLAST364

Proteomic databases

PRIDEiQ81JG5

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS3761

Structurei

3D structure databases

ProteinModelPortaliQ81JG5
SMRiQ81JG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218323
KOiK02563
OMAiHQTKNAM

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Q81JG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLVSGGGT GGHIYPALAL IREIKKLNPE ARFLYIGTEN GLESTIVPKA
60 70 80 90 100
GIPFQSIVIS GFKRKISLDN VKTVMRFLKG VQDSKRYIRR FNPDIVIGTG
110 120 130 140 150
GYVCGPVVYA AAKLGIPTIV HEQNSVPGVT NKFLSRYVDK VAVCFEAAAE
160 170 180 190 200
HFPQSKVVMT GNPRASEVMD QNGMKGKRSV GLSLPKKSVL IFGGSRGARP
210 220 230 240 250
INDAFVEAIE QFGNKSYEIL YVTGEVHYDK VMEAVKQKGN PNNVIIKPFI
260 270 280 290 300
HNMPEVLTGV DLVVSRAGAT TLAELTALGK PSVLIPSPYV TNNHQEKNAR
310 320 330 340 350
SVVDKGAAKM LLEKDLTAET LIRDIDEILL DAQTLQNMKL AAGQLGIPDA
360
ANKLYEVMNK LVKK
Length:364
Mass (Da):39,600
Last modified:June 1, 2003 - v1
Checksum:i2619A55B1E71F833
GO

Sequence cautioni

The sequence AAT56063 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27775.1
AE017334 Genomic DNA Translation: AAT33166.2
AE017225 Genomic DNA Translation: AAT56063.1 Different initiation.
RefSeqiNP_846289.1, NC_003997.3
WP_001265416.1, NZ_PPES01000010.1

Genome annotation databases

EnsemblBacteriaiAAP27775; AAP27775; BA_4049
AAT33166; AAT33166; GBAA_4049
AAT56063; AAT56063; BAS3761
GeneIDi1087469
KEGGiban:BA_4049
bar:GBAA_4049
PATRICifig|198094.11.peg.4020

Similar proteinsi

Entry informationi

Entry nameiMURG1_BACAN
AccessioniPrimary (citable) accession number: Q81JG5
Secondary accession number(s): Q6HUH6, Q6KNR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health