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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 1

Gene

murG1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciANTHRA:MURG-1-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 1UniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 1UniRule annotation
Gene namesi
Name:murG1UniRule annotation
Synonyms:murG-1
Ordered Locus Names:BA_4049, GBAA_4049, BAS3761
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001091381 – 364UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 1Add BLAST364

Proteomic databases

PRIDEiQ81JG5.

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_4049.

Structurei

3D structure databases

ProteinModelPortaliQ81JG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218323.
KOiK02563.
OMAiHQTKNAM.

Family and domain databases

CDDicd03785. GT1_MurG. 1 hit.
HAMAPiMF_00033. MurG. 1 hit.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81JG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLVSGGGT GGHIYPALAL IREIKKLNPE ARFLYIGTEN GLESTIVPKA
60 70 80 90 100
GIPFQSIVIS GFKRKISLDN VKTVMRFLKG VQDSKRYIRR FNPDIVIGTG
110 120 130 140 150
GYVCGPVVYA AAKLGIPTIV HEQNSVPGVT NKFLSRYVDK VAVCFEAAAE
160 170 180 190 200
HFPQSKVVMT GNPRASEVMD QNGMKGKRSV GLSLPKKSVL IFGGSRGARP
210 220 230 240 250
INDAFVEAIE QFGNKSYEIL YVTGEVHYDK VMEAVKQKGN PNNVIIKPFI
260 270 280 290 300
HNMPEVLTGV DLVVSRAGAT TLAELTALGK PSVLIPSPYV TNNHQEKNAR
310 320 330 340 350
SVVDKGAAKM LLEKDLTAET LIRDIDEILL DAQTLQNMKL AAGQLGIPDA
360
ANKLYEVMNK LVKK
Length:364
Mass (Da):39,600
Last modified:June 1, 2003 - v1
Checksum:i2619A55B1E71F833
GO

Sequence cautioni

The sequence AAT56063 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27775.1.
AE017334 Genomic DNA. Translation: AAT33166.2.
AE017225 Genomic DNA. Translation: AAT56063.1. Different initiation.
RefSeqiNP_846289.1. NC_003997.3.
WP_001265416.1. NZ_LHUO01000006.1.

Genome annotation databases

EnsemblBacteriaiAAP27775; AAP27775; BA_4049.
AAT33166; AAT33166; GBAA_4049.
AAT56063; AAT56063; BAS3761.
GeneIDi1087469.
KEGGiban:BA_4049.
bar:GBAA_4049.
PATRICi18785690. VBIBacAnt69550_4020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27775.1.
AE017334 Genomic DNA. Translation: AAT33166.2.
AE017225 Genomic DNA. Translation: AAT56063.1. Different initiation.
RefSeqiNP_846289.1. NC_003997.3.
WP_001265416.1. NZ_LHUO01000006.1.

3D structure databases

ProteinModelPortaliQ81JG5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_4049.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Proteomic databases

PRIDEiQ81JG5.

Protocols and materials databases

DNASUi1087469.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP27775; AAP27775; BA_4049.
AAT33166; AAT33166; GBAA_4049.
AAT56063; AAT56063; BAS3761.
GeneIDi1087469.
KEGGiban:BA_4049.
bar:GBAA_4049.
PATRICi18785690. VBIBacAnt69550_4020.

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218323.
KOiK02563.
OMAiHQTKNAM.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciANTHRA:MURG-1-MONOMER.

Family and domain databases

CDDicd03785. GT1_MurG. 1 hit.
HAMAPiMF_00033. MurG. 1 hit.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURG1_BACAN
AccessioniPrimary (citable) accession number: Q81JG5
Secondary accession number(s): Q6HUH6, Q6KNR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.