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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81MagnesiumUniRule annotation
Metal bindingi58 – 581MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciANTHRA:ACPS-MONOMER.
BANT260799:GJAJ-258-MONOMER.
BANT261594:GJ7F-266-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:BA_0250, GBAA_0250, BAS0236
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Holo-[acyl-carrier-protein] synthasePRO_0000175606Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_0250.

Structurei

Secondary structure

119
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 1111Combined sources
Helixi12 – 198Combined sources
Helixi25 – 295Combined sources
Helixi32 – 387Combined sources
Helixi44 – 6320Combined sources
Beta strandi68 – 714Combined sources
Helixi74 – 763Combined sources
Beta strandi78 – 814Combined sources
Beta strandi87 – 904Combined sources
Beta strandi94 – 10310Combined sources
Beta strandi105 – 11511Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HYKX-ray2.31A/B/C1-119[»]
ProteinModelPortaliQ81JG3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81JG3.

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082V8. Bacteria.
COG0736. LUCA.
HOGENOMiHOG000014315.
KOiK00997.
OMAiKDMEVVN.
OrthoDBiEOG6384R9.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. Ppantetheine-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81JG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVGIGIDII ELNRIEKMLD GKLKFMERIL TENERNVAKG LKGSRLTEFV
60 70 80 90 100
AGRFAAKEAY SKAVGTGIGK EVSFLDIEVR NDDRGKPILI TSTEHIVHLS
110
ISHSKEFAVA QVVLESSSS
Length:119
Mass (Da):13,100
Last modified:June 1, 2003 - v1
Checksum:i8680A0B258813E14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24289.1.
AE017334 Genomic DNA. Translation: AAT29331.1.
AE017225 Genomic DNA. Translation: AAT52572.1.
RefSeqiNP_842803.1. NC_003997.3.
WP_000635040.1. NZ_LHUO01000016.1.
YP_026521.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24289; AAP24289; BA_0250.
AAT29331; AAT29331; GBAA_0250.
AAT52572; AAT52572; BAS0236.
GeneIDi1087043.
2850731.
KEGGiban:BA_0250.
bar:GBAA_0250.
bat:BAS0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24289.1.
AE017334 Genomic DNA. Translation: AAT29331.1.
AE017225 Genomic DNA. Translation: AAT52572.1.
RefSeqiNP_842803.1. NC_003997.3.
WP_000635040.1. NZ_LHUO01000016.1.
YP_026521.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HYKX-ray2.31A/B/C1-119[»]
ProteinModelPortaliQ81JG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_0250.

Protocols and materials databases

DNASUi1087043.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP24289; AAP24289; BA_0250.
AAT29331; AAT29331; GBAA_0250.
AAT52572; AAT52572; BAS0236.
GeneIDi1087043.
2850731.
KEGGiban:BA_0250.
bar:GBAA_0250.
bat:BAS0236.

Phylogenomic databases

eggNOGiENOG41082V8. Bacteria.
COG0736. LUCA.
HOGENOMiHOG000014315.
KOiK00997.
OMAiKDMEVVN.
OrthoDBiEOG6384R9.

Enzyme and pathway databases

BioCyciANTHRA:ACPS-MONOMER.
BANT260799:GJAJ-258-MONOMER.
BANT261594:GJ7F-266-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81JG3.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. Ppantetheine-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiACPS_BACAN
AccessioniPrimary (citable) accession number: Q81JG3
Secondary accession number(s): Q6I4F9, Q6KY61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: January 20, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.