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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi58MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciANTHRA:ACPS-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:BA_0250, GBAA_0250, BAS0236
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001756061 – 119Holo-[acyl-carrier-protein] synthaseAdd BLAST119

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_0250.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 11Combined sources11
Helixi12 – 19Combined sources8
Helixi25 – 29Combined sources5
Helixi32 – 38Combined sources7
Helixi44 – 63Combined sources20
Beta strandi68 – 71Combined sources4
Helixi74 – 76Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi87 – 90Combined sources4
Beta strandi94 – 103Combined sources10
Beta strandi105 – 115Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HYKX-ray2.31A/B/C1-119[»]
ProteinModelPortaliQ81JG3.
SMRiQ81JG3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81JG3.

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082V8. Bacteria.
COG0736. LUCA.
HOGENOMiHOG000014315.
KOiK00997.
OMAiHGVSFQD.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS. 1 hit.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. Ppantetheine-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81JG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVGIGIDII ELNRIEKMLD GKLKFMERIL TENERNVAKG LKGSRLTEFV
60 70 80 90 100
AGRFAAKEAY SKAVGTGIGK EVSFLDIEVR NDDRGKPILI TSTEHIVHLS
110
ISHSKEFAVA QVVLESSSS
Length:119
Mass (Da):13,100
Last modified:June 1, 2003 - v1
Checksum:i8680A0B258813E14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24289.1.
AE017334 Genomic DNA. Translation: AAT29331.1.
AE017225 Genomic DNA. Translation: AAT52572.1.
RefSeqiNP_842803.1. NC_003997.3.
WP_000635040.1. NZ_LHUO01000016.1.
YP_026521.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP24289; AAP24289; BA_0250.
AAT29331; AAT29331; GBAA_0250.
AAT52572; AAT52572; BAS0236.
GeneIDi1087043.
2850731.
KEGGiban:BA_0250.
bar:GBAA_0250.
bat:BAS0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP24289.1.
AE017334 Genomic DNA. Translation: AAT29331.1.
AE017225 Genomic DNA. Translation: AAT52572.1.
RefSeqiNP_842803.1. NC_003997.3.
WP_000635040.1. NZ_LHUO01000016.1.
YP_026521.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HYKX-ray2.31A/B/C1-119[»]
ProteinModelPortaliQ81JG3.
SMRiQ81JG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_0250.

Protocols and materials databases

DNASUi1087043.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP24289; AAP24289; BA_0250.
AAT29331; AAT29331; GBAA_0250.
AAT52572; AAT52572; BAS0236.
GeneIDi1087043.
2850731.
KEGGiban:BA_0250.
bar:GBAA_0250.
bat:BAS0236.

Phylogenomic databases

eggNOGiENOG41082V8. Bacteria.
COG0736. LUCA.
HOGENOMiHOG000014315.
KOiK00997.
OMAiHGVSFQD.

Enzyme and pathway databases

BioCyciANTHRA:ACPS-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81JG3.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS. 1 hit.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. Ppantetheine-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACPS_BACAN
AccessioniPrimary (citable) accession number: Q81JG3
Secondary accession number(s): Q6I4F9, Q6KY61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.