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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi58MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:BA_0250, GBAA_0250, BAS0236
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001756061 – 119Holo-[acyl-carrier-protein] synthaseAdd BLAST119

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS0236

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 11Combined sources11
Helixi12 – 19Combined sources8
Helixi25 – 29Combined sources5
Helixi32 – 38Combined sources7
Helixi44 – 63Combined sources20
Beta strandi68 – 71Combined sources4
Helixi74 – 76Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi87 – 90Combined sources4
Beta strandi94 – 103Combined sources10
Beta strandi105 – 115Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HYKX-ray2.31A/B/C1-119[»]
ProteinModelPortaliQ81JG3
SMRiQ81JG3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81JG3

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082V8 Bacteria
COG0736 LUCA
HOGENOMiHOG000014315
KOiK00997
OMAiDERHYAV

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

Q81JG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVGIGIDII ELNRIEKMLD GKLKFMERIL TENERNVAKG LKGSRLTEFV
60 70 80 90 100
AGRFAAKEAY SKAVGTGIGK EVSFLDIEVR NDDRGKPILI TSTEHIVHLS
110
ISHSKEFAVA QVVLESSSS
Length:119
Mass (Da):13,100
Last modified:June 1, 2003 - v1
Checksum:i8680A0B258813E14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP24289.1
AE017334 Genomic DNA Translation: AAT29331.1
AE017225 Genomic DNA Translation: AAT52572.1
RefSeqiNP_842803.1, NC_003997.3
WP_000635040.1, NZ_PPES01000019.1
YP_026521.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP24289; AAP24289; BA_0250
AAT29331; AAT29331; GBAA_0250
AAT52572; AAT52572; BAS0236
GeneIDi1087043
2850731
KEGGiban:BA_0250
bar:GBAA_0250
bat:BAS0236
PATRICifig|198094.11.peg.244

Similar proteinsi

Entry informationi

Entry nameiACPS_BACAN
AccessioniPrimary (citable) accession number: Q81JG3
Secondary accession number(s): Q6I4F9, Q6KY61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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