Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1

Gene

fabH1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei112UniRule annotation1
Active sitei235UniRule annotation1
Active sitei265UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • fatty acid biosynthetic process Source: TIGR

Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1UniRule annotation (EC:2.3.1.180UniRule annotation)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III protein 1UniRule annotation
Beta-ketoacyl-ACP synthase III 1UniRule annotation
Short name:
KAS III 1UniRule annotation
Gene namesi
Name:fabH1UniRule annotation
Synonyms:fabH
Ordered Locus Names:BA_1184, GBAA_1184, BAS1095
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001103931 – 3103-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1Add BLAST310

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi260799.BAS1095

Structurei

3D structure databases

ProteinModelPortaliQ81JG0
SMRiQ81JG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 240ACP-bindingUniRule annotation5

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCZ Bacteria
COG0332 LUCA
HOGENOMiHOG000246674
KOiK00648
OMAiIGPTVWG

Family and domain databases

Gene3Di3.40.47.10, 1 hit
HAMAPiMF_01815 FabH, 1 hit
InterProiView protein in InterPro
IPR013751 ACP_syn_III
IPR013747 ACP_syn_III_C
IPR004655 FabH_synth
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF08545 ACP_syn_III, 1 hit
PF08541 ACP_syn_III_C, 1 hit
SUPFAMiSSF53901 SSF53901, 1 hit
TIGRFAMsiTIGR00747 fabH, 1 hit

Sequencei

Sequence statusi: Complete.

Q81JG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVGILGIGR YVPEKVVTNH DLEKIMDTSD EWIRTRTGIA ERRIADDTID
60 70 80 90 100
TSYMAVEASK KALEDAGISG EDIDLILVAT VTPDRAFPAV ACVIQEAIGA
110 120 130 140 150
KHAAAMDLSA ACAGFMYGMI TAQQFIQTGT YKNVLVVGSD KLSKIVDWND
160 170 180 190 200
RNTAVLFGDG AGAIVMGAVS EGKGVLSFEL GADGSGGKHL YQDEYVMMNG
210 220 230 240 250
REVFKFAVRQ LGDSCLRVLD KAGLTKEDVD FLVPHQANIR IMESARERLN
260 270 280 290 300
LPQEKMSMTI EKFGNTSASS IPIAMVEELQ NGRIQDGDLI ILVGFGGGLT
310
WGAVALRWGK
Length:310
Mass (Da):33,453
Last modified:June 1, 2003 - v1
Checksum:iABCA77867A4BA7B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP25147.1
AE017334 Genomic DNA Translation: AAT30271.1
AE017225 Genomic DNA Translation: AAT53418.1
RefSeqiNP_843661.1, NC_003997.3
WP_001100539.1, NZ_PPES01000003.1
YP_027367.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP25147; AAP25147; BA_1184
AAT30271; AAT30271; GBAA_1184
AAT53418; AAT53418; BAS1095
GeneIDi1089235
2851531
KEGGiban:BA_1184
bar:GBAA_1184
bat:BAS1095
PATRICifig|198094.11.peg.1163

Entry informationi

Entry nameiFABH1_BACAN
AccessioniPrimary (citable) accession number: Q81JG0
Secondary accession number(s): Q6I213, Q6KVV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health