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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1

Gene

fabH1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei112 – 1121UniRule annotation
Active sitei235 – 2351UniRule annotation
Active sitei265 – 2651UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • fatty acid biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciANTHRA:FABH-MONOMER.
BANT260799:GJAJ-1171-MONOMER.
BANT261594:GJ7F-1225-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1UniRule annotation (EC:2.3.1.180UniRule annotation)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III protein 1UniRule annotation
Beta-ketoacyl-ACP synthase III 1UniRule annotation
Short name:
KAS III 1UniRule annotation
Gene namesi
Name:fabH1UniRule annotation
Synonyms:fabH
Ordered Locus Names:BA_1184, GBAA_1184, BAS1095
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3103103-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1PRO_0000110393Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi198094.BA_1184.

Structurei

3D structure databases

ProteinModelPortaliQ81JG0.
SMRiQ81JG0. Positions 1-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni236 – 2405ACP-bindingUniRule annotation

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCZ. Bacteria.
COG0332. LUCA.
HOGENOMiHOG000246674.
KOiK00648.
OMAiMNGREVY.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01815. FabH. 1 hit.
InterProiIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
TIGRFAMsiTIGR00747. fabH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81JG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVGILGIGR YVPEKVVTNH DLEKIMDTSD EWIRTRTGIA ERRIADDTID
60 70 80 90 100
TSYMAVEASK KALEDAGISG EDIDLILVAT VTPDRAFPAV ACVIQEAIGA
110 120 130 140 150
KHAAAMDLSA ACAGFMYGMI TAQQFIQTGT YKNVLVVGSD KLSKIVDWND
160 170 180 190 200
RNTAVLFGDG AGAIVMGAVS EGKGVLSFEL GADGSGGKHL YQDEYVMMNG
210 220 230 240 250
REVFKFAVRQ LGDSCLRVLD KAGLTKEDVD FLVPHQANIR IMESARERLN
260 270 280 290 300
LPQEKMSMTI EKFGNTSASS IPIAMVEELQ NGRIQDGDLI ILVGFGGGLT
310
WGAVALRWGK
Length:310
Mass (Da):33,453
Last modified:June 1, 2003 - v1
Checksum:iABCA77867A4BA7B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25147.1.
AE017334 Genomic DNA. Translation: AAT30271.1.
AE017225 Genomic DNA. Translation: AAT53418.1.
RefSeqiNP_843661.1. NC_003997.3.
WP_001100539.1. NZ_LHUO01000014.1.
YP_027367.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP25147; AAP25147; BA_1184.
AAT30271; AAT30271; GBAA_1184.
AAT53418; AAT53418; BAS1095.
GeneIDi1089235.
2851531.
KEGGiban:BA_1184.
bar:GBAA_1184.
bat:BAS1095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25147.1.
AE017334 Genomic DNA. Translation: AAT30271.1.
AE017225 Genomic DNA. Translation: AAT53418.1.
RefSeqiNP_843661.1. NC_003997.3.
WP_001100539.1. NZ_LHUO01000014.1.
YP_027367.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81JG0.
SMRiQ81JG0. Positions 1-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_1184.

Protocols and materials databases

DNASUi1089235.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP25147; AAP25147; BA_1184.
AAT30271; AAT30271; GBAA_1184.
AAT53418; AAT53418; BAS1095.
GeneIDi1089235.
2851531.
KEGGiban:BA_1184.
bar:GBAA_1184.
bat:BAS1095.

Phylogenomic databases

eggNOGiENOG4105CCZ. Bacteria.
COG0332. LUCA.
HOGENOMiHOG000246674.
KOiK00648.
OMAiMNGREVY.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciANTHRA:FABH-MONOMER.
BANT260799:GJAJ-1171-MONOMER.
BANT261594:GJ7F-1225-MONOMER.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01815. FabH. 1 hit.
InterProiIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
TIGRFAMsiTIGR00747. fabH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFABH1_BACAN
AccessioniPrimary (citable) accession number: Q81JG0
Secondary accession number(s): Q6I213, Q6KVV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.