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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2

Gene

fabH2

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei114UniRule annotation1
Active sitei251UniRule annotation1
Active sitei281UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2UniRule annotation (EC:2.3.1.180UniRule annotation)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III protein 2UniRule annotation
Beta-ketoacyl-ACP synthase III 2UniRule annotation
Short name:
KAS III 2UniRule annotation
Gene namesi
Name:fabH2UniRule annotation
Ordered Locus Names:BA_1826, GBAA_1826, BAS1691
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001103941 – 3273-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2Add BLAST327

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi260799.BAS1691

Structurei

3D structure databases

ProteinModelPortaliQ81JF6
SMRiQ81JF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 256ACP-bindingUniRule annotation5

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0332 LUCA
HOGENOMiHOG000246674
KOiK00648
OMAiMWLHQAN

Family and domain databases

Gene3Di3.40.47.10, 1 hit
HAMAPiMF_01815 FabH, 1 hit
InterProiView protein in InterPro
IPR013751 ACP_syn_III
IPR013747 ACP_syn_III_C
IPR004655 FabH_synth
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF08545 ACP_syn_III, 1 hit
PF08541 ACP_syn_III_C, 1 hit
SUPFAMiSSF53901 SSF53901, 1 hit
TIGRFAMsiTIGR00747 fabH, 1 hit

Sequencei

Sequence statusi: Complete.

Q81JF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKSRITAI GTHVPNQILS NNDLEKMIDT NDEWIVQRTG MKERRIASED
60 70 80 90 100
EYSSNLAIKA VENLCTTYKK NLEDVDCIIV ATTTADYVFP SVACQIQQYF
110 120 130 140 150
NIPHTMAFDL NATCAGFTYG LHVGNSLITS GSHKKVLVVA TETLSKVTDY
160 170 180 190 200
TDRTTCILFG DGAGAILLER DENKPSFIAY HMGTNGHGGI HLYRTNLSTT
210 220 230 240 250
MNDTPLQTNE KIVQNGREVY KWATRTVPVG IKELLHTANM KMDDIDWFIP
260 270 280 290 300
HSANLRMIES ICEKSQIPIH KTLTSVEYMG NTSSVSIPLA LDLARKKGKL
310 320
NNGDTLLLYG FGGGLTHLGL IVEWDLS
Length:327
Mass (Da):36,280
Last modified:June 1, 2003 - v1
Checksum:i342E6463194A011E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP25732.1
AE017334 Genomic DNA Translation: AAT30939.1
AE017225 Genomic DNA Translation: AAT54008.1
RefSeqiNP_844246.1, NC_003997.3
WP_001086320.1, NZ_NRJB01000003.1
YP_027957.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP25732; AAP25732; BA_1826
AAT30939; AAT30939; GBAA_1826
AAT54008; AAT54008; BAS1691
GeneIDi1086168
2851898
KEGGiban:BA_1826
bar:GBAA_1826
bat:BAS1691
PATRICifig|198094.11.peg.1796

Similar proteinsi

Entry informationi

Entry nameiFABH2_BACAN
AccessioniPrimary (citable) accession number: Q81JF6
Secondary accession number(s): Q6I0C9, Q6KUA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health