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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2

Gene

murG2

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2UniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 2UniRule annotation
Gene namesi
Name:murG2UniRule annotation
Synonyms:murG-2
Ordered Locus Names:BA_4477, GBAA_4477, BAS4155
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001091391 – 352UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2Add BLAST352

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS4155

Structurei

3D structure databases

ProteinModelPortaliQ81JE6
SMRiQ81JE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218322
KOiK02563
OMAiNSIFEFL

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Q81JE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIVFTGGG SAGHVTPNLA IIPYLKEDNW DISYIGSHQG IEKTIIEKED
60 70 80 90 100
IPYYSIASGK LRRYFDLKNI KDPFLVMKGV MDAYVRIRKL KPDVIFSKGG
110 120 130 140 150
FVSVPVVIGG WLNRVPVLLH ESDMTPGLAN KIALRFASKI FVTFEEAAKH
160 170 180 190 200
LPKEKVIYTG SPVREEVLKG DREKALAFLG FSRKKPVITI MGGSLGAKKI
210 220 230 240 250
NETVREALPE LLRKYQIVHL CGKGNLDDSL QNKEGYRQFE YVHGELPDIL
260 270 280 290 300
AITDFVISRA GSNAIFEFLT LQKPMLLIPL SKFASRGDQI LNAESFERQG
310 320 330 340 350
YASVLYEEDV TVNSLIKHVE ELSHNNEAYK TALKKYNGKE AIQTIIHHIS

EA
Length:352
Mass (Da):39,508
Last modified:June 1, 2003 - v1
Checksum:i21492D0FB8A476F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP28188.1
AE017334 Genomic DNA Translation: AAT33595.1
AE017225 Genomic DNA Translation: AAT56455.1
RefSeqiNP_846702.1, NC_003997.3
WP_000724762.1, NZ_NVHS01000047.1
YP_030404.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP28188; AAP28188; BA_4477
AAT33595; AAT33595; GBAA_4477
AAT56455; AAT56455; BAS4155
GeneIDi1087934
2853063
KEGGiban:BA_4477
bar:GBAA_4477
bat:BAS4155
PATRICifig|198094.11.peg.4445

Similar proteinsi

Entry informationi

Entry nameiMURG2_BACAN
AccessioniPrimary (citable) accession number: Q81JE6
Secondary accession number(s): Q6HTD4, Q6KMM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health