Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei595For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:BC_0190
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001352952 – 600Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST599

Proteomic databases

PRIDEiQ81J01.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi226900.BC0190.

Structurei

3D structure databases

ProteinModelPortaliQ81J01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2UniRule annotationAdd BLAST216
Domaini283 – 422SIS 1UniRule annotationAdd BLAST140
Domaini452 – 590SIS 2UniRule annotationAdd BLAST139

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiGEFFCAS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q81J01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGFIGE QDAKEILLKG LEKLEYRGYD SAGIAVQAEN GVVVYKEKGR
60 70 80 90 100
IAKLREIVDE NVAASVGIGH TRWATHGVPS KVNAHPHQST SKRFTLVHNG
110 120 130 140 150
VIENYELVKK EYLQDVTFVS ETDTEVIVQL MEQQVSTGLS VEEAFRNTLS
160 170 180 190 200
LLHGSYAIGL LDAENPNMIY VAKNKSPLLV GVGDNFNVVA SDAMAMLQVT
210 220 230 240 250
DQFIELMDKE IVIVTKESIT IKNLQGETIE RAPFTAELDA SDIEKGTYPH
260 270 280 290 300
FMLKEIDEQP LVIRNIIQKY QDENGEIELN QDIRNAILDS DRIYIIACGT
310 320 330 340 350
SYHAGLVGKQ FIEKFAKMPV EVHVASEFSY NMPLLTERPF FIYISQSGET
360 370 380 390 400
ADSRAVLVQT NEMGHKALTI TNVPGSTLSR EADYTLPLYA GPEIAVASTK
410 420 430 440 450
AYTAQLAVLS ILAADIAKAK GEVLDFDLTH ELGLVANAMI ELCDQKEEMD
460 470 480 490 500
ALAKQFLATT RNCFFIGRSV DFYVGLEGAL KLKEISYIQA EGFAGGELKH
510 520 530 540 550
GTIALIENGT PVIALATQEH VNLGIRGNVK EVVARGANPC IISMKGLEME
560 570 580 590 600
GDSFVLPTVH EALAPLVAVI PLQLISYYAA LHRECDVDKP RNLAKSVTVE
Length:600
Mass (Da):65,822
Last modified:January 23, 2007 - v3
Checksum:i4B09F34374ED1F88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP07259.1.
RefSeqiNP_830058.1. NC_004722.1.
WP_000334164.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP07259; AAP07259; BC_0190.
GeneIDi1202543.
KEGGibce:BC0190.
PATRICi32595994. VBIBacCer54481_0181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP07259.1.
RefSeqiNP_830058.1. NC_004722.1.
WP_000334164.1. NC_004722.1.

3D structure databases

ProteinModelPortaliQ81J01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226900.BC0190.

Protein family/group databases

MEROPSiC44.971.

Proteomic databases

PRIDEiQ81J01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP07259; AAP07259; BC_0190.
GeneIDi1202543.
KEGGibce:BC0190.
PATRICi32595994. VBIBacCer54481_0181.

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiGEFFCAS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLMS_BACCR
AccessioniPrimary (citable) accession number: Q81J01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.