Reviewed,
UniProtKB/Swiss-Prot Q81IP9 (PUR9_BACCR)
Last modified
February 9, 2010.
Version 39.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional purine biosynthesis protein purH Including the following 2 domains: 1- Recommended name: Phosphoribosylaminoimidazolecarboxamide formyltransferase EC=2.1.2.3 Alternative name(s): AICAR transformylase 2- Recommended name: IMP cyclohydrolase EC=3.5.4.10 Alternative name(s): Inosinicase IMP synthetase ATIC | ||||
| Gene names |
| ||||
| Organism | Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 226900 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 511 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP MF_00139 |
| Domain | The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP MF_00139 |
| Sequence similarities | Belongs to the purH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Molecular function | Hydrolase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | IMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP phosphoribosylaminoimidazolecarboxamide formyltransferase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 511 | 511 | Bifunctional purine biosynthesis protein purH HAMAP MF_00139 | PRO_1000018840 | |||
Sequences
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References
| [1] | "Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. Kyrpides N.C.Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016877 Genomic DNA. Translation: AAP07373.1. |
| RefSeq | NP_830172.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1PKX based on UniProtKB P31939. |
| SMR | Q81IP9. Positions 3-511. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q81IP9. |
Genome annotation databases | |
| GeneID | 1202686. |
| GenomeReviews | Gene locus BC_0333 in contig AE016877_GR. |
| KEGG | bce:BC0333. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0138. |
| HOGENOM | HBG498048. |
| OMA | VVKHVKS. |
Enzyme and pathway databases | |
| BioCyc | BCER226900:BC_0333-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00139. PurH. [Tree] |
| InterPro | IPR002695. AICARFT_IMPCHas. IPR013982. AICARFT_IMPCHase_bienz. IPR011607. MGS. [Graphical view] |
| PANTHER | PTHR11692. AICARFT_IMPCHas. 1 hit. |
| Pfam | PF01808. AICARFT_IMPCHas. 1 hit. PF02142. MGS. 1 hit. [Graphical view] |
| PIRSF | PIRSF000414. AICARFT_IMPCHas. 1 hit. |
| SMART | SM00798. AICARFT_IMPCHas. 1 hit. SM00851. MGS. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00355. purH. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PUR9_BACCR | ||||||||
| Accession | Primary (citable) accession number: Q81IP9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


