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Protein
Submitted name:

Potassium channel protein

Gene

BC_0669

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Ion channelImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciBCER226900:GJEU-670-MONOMER.

Protein family/group databases

TCDBi1.A.1.21.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel proteinImported
Gene namesi
Ordered Locus Names:BC_0669Imported
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)Imported
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4520HelicalSequence analysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

DIPiDIP-46436N.
STRINGi226900.BC0669.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AHYX-ray2.40A/B1-110[»]
2AHZX-ray2.80A/B1-110[»]
2Q67X-ray2.30A/B1-110[»]
2Q68X-ray2.50A/B1-110[»]
2Q69X-ray2.40A/B1-110[»]
2Q6AX-ray2.60A/B1-110[»]
3E83X-ray1.80A/B19-110[»]
3E86X-ray1.60A/B19-110[»]
3E89X-ray1.80A/B19-110[»]
3E8BX-ray1.70A/B19-110[»]
3E8FX-ray2.00A/B19-110[»]
3E8GX-ray2.00A/B19-110[»]
3E8HX-ray1.80A/B19-110[»]
3K03X-ray1.62A/B20-110[»]
3K04X-ray1.58A/B20-110[»]
3K06X-ray1.58A/B20-66[»]
A/B69-110[»]
3K08X-ray1.62A/B20-66[»]
A/B69-110[»]
3K0DX-ray1.95A/B20-110[»]
3K0GX-ray1.95A/B20-110[»]
3T1CX-ray1.80A/B20-110[»]
3T2MX-ray1.95A/B20-110[»]
3T4DX-ray1.70A/B20-110[»]
3T4ZX-ray1.90A/B20-110[»]
3TCUX-ray1.75A/B20-110[»]
3TETX-ray1.90A/B20-110[»]
4PDLX-ray1.70A/B20-110[»]
4PDMX-ray1.58A/B20-110[»]
4PDRX-ray1.85A/B20-110[»]
4PDVX-ray1.82A/B20-110[»]
4R50X-ray2.85A/B20-110[»]
4R6ZX-ray2.30A/B20-110[»]
4R7CX-ray2.30A/B/C/D20-110[»]
4R8CX-ray2.50A/B20-110[»]
4RAIX-ray2.31A/B20-110[»]
4RO2X-ray2.70A/B/C/D20-110[»]
4ZBMX-ray1.90A/B20-110[»]
ProteinModelPortaliQ81HW2.
SMRiQ81HW2. Positions 1-105.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81HW2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9970Ion_trans_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG41062FE. Bacteria.
COG1226. LUCA.
OMAiTMAYITI.
OrthoDBiEOG6QZMPQ.

Family and domain databases

InterProiIPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81HW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSFLLTLKR MLRACLRAWK DKEFQVLFVL TILTLISGTI FYSTVEGLRP
60 70 80 90 100
IDALYFSVVT LTTVGDGNFS PQTDFGKIFT ILYIFIGIGL VFGFIHKLAV
110
NVQLPSILSN RKKE
Length:114
Mass (Da):12,894
Last modified:June 1, 2003 - v1
Checksum:i3D892E9FCF26E63C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP07683.1.
RefSeqiNP_830482.1. NC_004722.1.
WP_000948210.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP07683; AAP07683; BC_0669.
GeneIDi1203020.
KEGGibce:BC0669.
PATRICi32596987. VBIBacCer54481_0630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP07683.1.
RefSeqiNP_830482.1. NC_004722.1.
WP_000948210.1. NC_004722.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AHYX-ray2.40A/B1-110[»]
2AHZX-ray2.80A/B1-110[»]
2Q67X-ray2.30A/B1-110[»]
2Q68X-ray2.50A/B1-110[»]
2Q69X-ray2.40A/B1-110[»]
2Q6AX-ray2.60A/B1-110[»]
3E83X-ray1.80A/B19-110[»]
3E86X-ray1.60A/B19-110[»]
3E89X-ray1.80A/B19-110[»]
3E8BX-ray1.70A/B19-110[»]
3E8FX-ray2.00A/B19-110[»]
3E8GX-ray2.00A/B19-110[»]
3E8HX-ray1.80A/B19-110[»]
3K03X-ray1.62A/B20-110[»]
3K04X-ray1.58A/B20-110[»]
3K06X-ray1.58A/B20-66[»]
A/B69-110[»]
3K08X-ray1.62A/B20-66[»]
A/B69-110[»]
3K0DX-ray1.95A/B20-110[»]
3K0GX-ray1.95A/B20-110[»]
3T1CX-ray1.80A/B20-110[»]
3T2MX-ray1.95A/B20-110[»]
3T4DX-ray1.70A/B20-110[»]
3T4ZX-ray1.90A/B20-110[»]
3TCUX-ray1.75A/B20-110[»]
3TETX-ray1.90A/B20-110[»]
4PDLX-ray1.70A/B20-110[»]
4PDMX-ray1.58A/B20-110[»]
4PDRX-ray1.85A/B20-110[»]
4PDVX-ray1.82A/B20-110[»]
4R50X-ray2.85A/B20-110[»]
4R6ZX-ray2.30A/B20-110[»]
4R7CX-ray2.30A/B/C/D20-110[»]
4R8CX-ray2.50A/B20-110[»]
4RAIX-ray2.31A/B20-110[»]
4RO2X-ray2.70A/B/C/D20-110[»]
4ZBMX-ray1.90A/B20-110[»]
ProteinModelPortaliQ81HW2.
SMRiQ81HW2. Positions 1-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46436N.
STRINGi226900.BC0669.

Protein family/group databases

TCDBi1.A.1.21.1. the voltage-gated ion channel (vic) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP07683; AAP07683; BC_0669.
GeneIDi1203020.
KEGGibce:BC0669.
PATRICi32596987. VBIBacCer54481_0630.

Phylogenomic databases

eggNOGiENOG41062FE. Bacteria.
COG1226. LUCA.
OMAiTMAYITI.
OrthoDBiEOG6QZMPQ.

Enzyme and pathway databases

BioCyciBCER226900:GJEU-670-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81HW2.

Family and domain databases

InterProiIPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711Imported.
  2. "Atomic structure of a Na+- and K+-conducting channel."
    Shi N., Ye S., Alam A., Chen L., Jiang Y.
    Nature 440:570-574(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 1-110.
  3. "Structural insight into Ca2+ specificity in tetrameric cation channels."
    Alam A., Shi N., Jiang Y.
    Proc. Natl. Acad. Sci. U.S.A. 104:15334-15339(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-110.
  4. "High-resolution structure of the open NaK channel."
    Alam A., Jiang Y.
    Nat. Struct. Mol. Biol. 16:30-34(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 19-110.
  5. "Structural analysis of ion selectivity in the NaK channel."
    Alam A., Jiang Y.
    Nat. Struct. Mol. Biol. 16:35-41(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 19-110.
  6. "Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore."
    Derebe M.G., Zeng W., Li Y., Alam A., Jiang Y.
    Proc. Natl. Acad. Sci. U.S.A. 108:592-597(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 20-66 AND 69-110.
  7. "Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites."
    Derebe M.G., Sauer D.B., Zeng W., Alam A., Shi N., Jiang Y.
    Proc. Natl. Acad. Sci. U.S.A. 108:598-602(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 20-110.
  8. "Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation."
    Sauer D.B., Zeng W., Raghunathan S., Jiang Y.
    Proc. Natl. Acad. Sci. U.S.A. 108:16634-16639(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 20-110.
  9. "High Resolution Structural Views of Rubidium, Cesium and Barium Binding within a Potassium Selective Channel Filter."
    Lam Y., Zeng W., Sauer D., Jiang Y.
    Submitted (APR-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 20-110.
  10. "Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide-gated channels."
    Lam Y.L., Zeng W., Derebe M.G., Jiang Y.
    J. Gen. Physiol. 146:255-263(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 20-110.
  11. "A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels."
    Napolitano L.M., Bisha I., De March M., Marchesi A., Arcangeletti M., Demitri N., Mazzolini M., Rodriguez A., Magistrato A., Onesti S., Laio A., Torre V.
    Proc. Natl. Acad. Sci. U.S.A. 112:E3619-E3628(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 20-110.

Entry informationi

Entry nameiQ81HW2_BACCR
AccessioniPrimary (citable) accession number: Q81HW2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 13, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.