Reviewed, UniProtKB/Swiss-Prot Q81HV4 (UPPP1_BACCR)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Synonyms:	bacA1, upk1
Ordered Locus Names:	BC_0677

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000151091
Regions
	Transmembrane	5 – 25	21	Potential
	Transmembrane	42 – 62	21	Potential
	Transmembrane	89 – 109	21	Potential
	Transmembrane	117 – 137	21	Potential
	Transmembrane	192 – 212	21	Potential
	Transmembrane	220 – 240	21	Potential
	Transmembrane	250 – 270	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q81HV4-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 304CAA47A19A5E4B	FASTA	270	29,934
	10 20 30 40 50 60 MEQFYYVLKY LILGLFQGLT EPIPISSSGH LVLAQHLLGL KIEGFSFELL VNSASLLAVL 70 80 90 100 110 120 LIYRNDLIRL TKNGLSYIFT RAEDAKSDFF FIIYLVIATI PAGVIGVLFK DYIDQYLKGV 130 140 150 160 170 180 KMVGISLLIT AVGLWIIRNL RGRKNDGDLS MKDAIIVGLA QACALIPGIS RSGATIVAAM 190 200 210 220 230 240 LLGMKQETAL RFSFLLYIPV SLGGLLLSIT DIANDPNLDT LFVPYVVAFI ATFIMTYISL 250 260 270 KWFMNIMAKG NLKYFSFYCI IVGVLTLIFL

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016877 Genomic DNA. Translation: AAP07691.1.
RefSeq	NP_830490.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q81HV4.
Genome annotation databases
GeneID	1203028.
GenomeReviews	Gene locus BC_0677 in contig AE016877_GR.
KEGG	bce:BC0677.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	FALLWYF.
Enzyme and pathway databases
BioCyc	BCER226900:BC_0677-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP1_BACCR

Accession

Primary (citable) accession number: Q81HV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2003
Last modified:	January 19, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)