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Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBCER226900:GJEU-678-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 1UniRule annotation
Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
Gene namesi
Name:uppP1UniRule annotation
Synonyms:bacA1, upk1
Ordered Locus Names:BC_0677
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417 Componenti: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalUniRule annotationAdd
BLAST
Transmembranei42 – 6221HelicalUniRule annotationAdd
BLAST
Transmembranei89 – 10921HelicalUniRule annotationAdd
BLAST
Transmembranei117 – 13721HelicalUniRule annotationAdd
BLAST
Transmembranei192 – 21221HelicalUniRule annotationAdd
BLAST
Transmembranei220 – 24021HelicalUniRule annotationAdd
BLAST
Transmembranei250 – 27021HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Undecaprenyl-diphosphatase 1PRO_0000151091Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226900.BC0677.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiIGLWIIR.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81HV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQFYYVLKY LILGLFQGLT EPIPISSSGH LVLAQHLLGL KIEGFSFELL
60 70 80 90 100
VNSASLLAVL LIYRNDLIRL TKNGLSYIFT RAEDAKSDFF FIIYLVIATI
110 120 130 140 150
PAGVIGVLFK DYIDQYLKGV KMVGISLLIT AVGLWIIRNL RGRKNDGDLS
160 170 180 190 200
MKDAIIVGLA QACALIPGIS RSGATIVAAM LLGMKQETAL RFSFLLYIPV
210 220 230 240 250
SLGGLLLSIT DIANDPNLDT LFVPYVVAFI ATFIMTYISL KWFMNIMAKG
260 270
NLKYFSFYCI IVGVLTLIFL
Length:270
Mass (Da):29,934
Last modified:June 1, 2003 - v1
Checksum:i304CAA47A19A5E4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP07691.1.
RefSeqiNP_830490.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP07691; AAP07691; BC_0677.
GeneIDi1203028.
KEGGibce:BC0677.
PATRICi32597001. VBIBacCer54481_0637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP07691.1.
RefSeqiNP_830490.1. NC_004722.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226900.BC0677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP07691; AAP07691; BC_0677.
GeneIDi1203028.
KEGGibce:BC0677.
PATRICi32597001. VBIBacCer54481_0637.

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiIGLWIIR.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciBCER226900:GJEU-678-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31.

Entry informationi

Entry nameiUPPP1_BACCR
AccessioniPrimary (citable) accession number: Q81HV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.