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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCER226900:GJEU-1003-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:BC_1003
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Serine-protein kinase RsbWPRO_0000203527Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226900.BC1003.

Structurei

3D structure databases

ProteinModelPortaliQ81H23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2172. LUCA.
KOiK04757.
OMAiKMGFSYE.
OrthoDBiEOG6S7XW5.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81H23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMERFEKIEM KIPAKAEYVA IIRLTMAGVA NRMGFAYDDI EDMKIAISEA
60 70 80 90 100
CTNIVQHAYK EDVGEIAIVF GLYENRLEIM VADNGVSFDF NNLKRKVGPY
110 120 130 140 150
DISKPVEHLP ENGLGLYLIN TLMDDIQIMH DEGMTVLMTK YIQREQVEND
160
GNPISTYESY
Length:160
Mass (Da):18,282
Last modified:June 1, 2003 - v1
Checksum:i20DD3A06B44E109A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP07990.1.
RefSeqiNP_830789.1. NC_004722.1.
WP_000970576.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP07990; AAP07990; BC_1003.
GeneIDi1203352.
KEGGibce:BC1003.
PATRICi32597690. VBIBacCer54481_0957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP07990.1.
RefSeqiNP_830789.1. NC_004722.1.
WP_000970576.1. NC_004722.1.

3D structure databases

ProteinModelPortaliQ81H23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226900.BC1003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP07990; AAP07990; BC_1003.
GeneIDi1203352.
KEGGibce:BC1003.
PATRICi32597690. VBIBacCer54481_0957.

Phylogenomic databases

eggNOGiCOG2172. LUCA.
KOiK04757.
OMAiKMGFSYE.
OrthoDBiEOG6S7XW5.

Enzyme and pathway databases

BioCyciBCER226900:GJEU-1003-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711.

Entry informationi

Entry nameiRSBW_BACCR
AccessioniPrimary (citable) accession number: Q81H23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.