Reviewed, UniProtKB/Swiss-Prot Q81GW5 (HEMH1_BACCR)

Names and origin

Protein names

Recommended name:
    Ferrochelatase 1
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase 1
    Heme synthetase 1

Gene names

Name:	hemH1
Ordered Locus Names:	BC_1069

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Ferrochelatase 1 HAMAP MF_00323		PRO_0000175106
Sites
	Metal binding	182	1	Iron By similarity
	Metal binding	263	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q81GW5-1 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 56FB647F2368BA0E	FASTA	311	35,302
	10 20 30 40 50 60 MKKKIGLLVM AYGTPYKEED IERYYTHIRR GRKPSPEMLE DLTERYRAIG GISPLATITL 70 80 90 100 110 120 EQAKKLEKRL NEVQDEVEYH MYLGLKHIEP FIEDAVKDMH NDGIQDAIAL VLAPHYSTFS 130 140 150 160 170 180 VKSYVGRAQE EAEKLGNLTI HGIDSWYKEP KFIQYWVDAV KGIYNGMSDA EREKAVLIVS 190 200 210 220 230 240 AHSLPEKIIA MGDPYPDQLN ETADYIARGA EVANYAVGWQ SAGNTPDPWI GPDVQDLTRE 250 260 270 280 290 300 LNEKHGYTSF VYAPVGFVAE HLEVLYDNDF ECKVVTDEIG AKYYRPEMPN ASDAFIDCLT 310 DVVLKKKESV L

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016877 Genomic DNA. Translation: AAP08056.1. Different initiation.
RefSeq	NP_830855.1.
3D structure databases
SMR	Q81GW5. Positions 1-311.
ModBase	Search...
Protein-protein interaction databases
STRING	Q81GW5.
Genome annotation databases
GeneID	1203418.
GenomeReviews	Gene locus BC_1069 in contig AE016877_GR.
KEGG	bce:BC1069.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0276.
HOGENOM	HBG697135.
Enzyme and pathway databases
BioCyc	BCER226900:BC_1069-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH1_BACCR

Accession

Primary (citable) accession number: Q81GW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	February 1, 2005
Last modified:	February 9, 2010
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)