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Q81GJ9

- NADK1_BACCR

UniProt

Q81GJ9 - NADK1_BACCR

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Protein

NAD kinase 1

Gene

nadK1

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptorUniRule annotation
Binding sitei148 – 1481NADUniRule annotation
Binding sitei150 – 1501NADUniRule annotation
Binding sitei185 – 1851NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 462NADUniRule annotation
Nucleotide bindingi122 – 1232NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCER226900:GJEU-1199-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 1UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 1UniRule annotation
Gene namesi
Name:nadK1UniRule annotation
Ordered Locus Names:BC_1199
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265NAD kinase 1PRO_0000120593Add
BLAST

Proteomic databases

PRIDEiQ81GJ9.

Interactioni

Protein-protein interaction databases

STRINGi226900.BC1199.

Structurei

3D structure databases

ProteinModelPortaliQ81GJ9.
SMRiQ81GJ9. Positions 1-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiQWITIVP.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81GJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFTIMSKGD QSSDTLASTM KEYLLDFGFI MDEKEPDIVI SVGGDGTLLY
60 70 80 90 100
AFHRYYNRLD ETAFVGVHTG HLGFYADWLP TEVEKLVIAI AKTPFQVVEY
110 120 130 140 150
PLLEVIIRYV NGSKESQYLA MNEATVKSAE GTLVTEVEIR GEYFETFRGD
160 170 180 190 200
GLCISTPSGS TAYNKALGGA IIHPSIEAIQ IAEMASINNR VFRTVGSPLV
210 220 230 240 250
LPKHHTCVLK PAAGMNLQIT VDHLTMVHQD VKSIQYRVAN EKVRFVRFRP
260
FPFWKRVRDS FVADK
Length:265
Mass (Da):29,766
Last modified:June 1, 2003 - v1
Checksum:i53DA54FC1976DAB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP08185.1.
RefSeqiNP_830984.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP08185; AAP08185; BC_1199.
GeneIDi1203548.
KEGGibce:BC1199.
PATRICi32598111. VBIBacCer54481_1167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP08185.1 .
RefSeqi NP_830984.1. NC_004722.1.

3D structure databases

ProteinModelPortali Q81GJ9.
SMRi Q81GJ9. Positions 1-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226900.BC1199.

Proteomic databases

PRIDEi Q81GJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP08185 ; AAP08185 ; BC_1199 .
GeneIDi 1203548.
KEGGi bce:BC1199.
PATRICi 32598111. VBIBacCer54481_1167.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi QWITIVP.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci BCER226900:GJEU-1199-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31.

Entry informationi

Entry nameiNADK1_BACCR
AccessioniPrimary (citable) accession number: Q81GJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3