Reviewed, UniProtKB/Swiss-Prot Q81GG7 (TRPC_BACCR)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BC_1235

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_0000154209

Sequences

	Sequence		Length	Mass (Da)
	Q81GG7-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 2519649E1A8081C8	FASTA	253	28,290
	10 20 30 40 50 60 MGTILDKIVE QKKKEVAELY EIYTPVKTKR KTQSLVEALQ QFTVIAEVKR ASPSKGDINL 70 80 90 100 110 120 HVDVRKQVGT YEKCGAGAVS VLTDGQFFKG SFHDLQTARE ESNIPLLCKD FIIDKIQIDR 130 140 150 160 170 180 AYEAGADIIL LIVAALTKEK LKELYSYVLE KGLEAIVEVH DEQELETAIV LNPHVIGINN 190 200 210 220 230 240 RNLKTFEVDL SQTEKLGKRL NEEKLLWISE SGIHSKEDII RVKRAGAKGV LVGEALMTSS 250 SISSFFEDCK VNI

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016877 Genomic DNA. Translation: AAP08220.1.
RefSeq	NP_831019.1.
3D structure databases
HSSP	HSSP built from PDB template 1PII based on UniProtKB P00909.
ModBase	Search...
Protein-protein interaction databases
STRING	Q81GG7.
Genome annotation databases
GeneID	1203584.
GenomeReviews	Gene locus BC_1235 in contig AE016877_GR.
KEGG	bce:BC1235.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q81GG7.
OMA	PLLCKDF.
Enzyme and pathway databases
BioCyc	BCER226900:BC_1235-MON.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
ProDom	PD001511. IGPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACCR

Accession

Primary (citable) accession number: Q81GG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)