Reviewed,
UniProtKB/Swiss-Prot Q81G66 (QUEF_BACCR)
Last modified
February 9, 2010.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADPH-dependent 7-cyano-7-deazaguanine reductase EC=1.7.1.13 Alternative name(s): 7-cyano-7-carbaguanine reductase PreQ(0) reductase NADPH-dependent nitrile oxidoreductase | ||||
| Gene names |
| ||||
| Organism | Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 226900 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 165 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity. HAMAP MF_00818 |
| Catalytic activity | 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH. HAMAP MF_00818 |
| Pathway | tRNA modification; tRNA-queuosine biosynthesis. HAMAP MF_00818 |
| Subcellular location | Cytoplasm Probable HAMAP MF_00818. |
| Sequence similarities | Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Queuosine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW queuosine biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Inferred from electronic annotation. Source: HAMAP queuine synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 165 | 165 | NADPH-dependent 7-cyano-7-deazaguanine reductase HAMAP MF_00818 | PRO_0000162952 | |||
Sequences
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References
| [1] | "Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. Kyrpides N.C.Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016877 Genomic DNA. Translation: AAP08326.1. |
| RefSeq | NP_831125.1. |
3D structure databases | |
| SMR | Q81G66. Positions 60-136. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q81G66. |
Genome annotation databases | |
| GeneID | 1203693. |
| GenomeReviews | Gene locus BC_1344 in contig AE016877_GR. |
| KEGG | bce:BC1344. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0780. |
| HOGENOM | HBG294103. |
| OMA | HESCINT. |
Enzyme and pathway databases | |
| BioCyc | BCER226900:BC_1344-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00818. QueF_type1. [Tree] |
| InterPro | IPR016856. CN_OxRdtase_NADPH-dep_QueF. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. [Graphical view] |
| Pfam | PF01227. GTP_cyclohydroI. 1 hit. [Graphical view] |
| PIRSF | PIRSF027377. Nitrile_oxidored_QueF. 1 hit. |
| TIGRFAMs | TIGR03139. QueF-II. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | QUEF_BACCR | ||||||||
| Accession | Primary (citable) accession number: Q81G66 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


