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Q81G27

- UPPP2_BACCR

UniProt

Q81G27 - UPPP2_BACCR

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Protein
Undecaprenyl-diphosphatase 2
Gene
uppP2, bacA2, upk2, BC_1384
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBCER226900:GJEU-1384-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene namesi
Name:uppP2
Synonyms:bacA2, upk2
Ordered Locus Names:BC_1384
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3723Helical; Reviewed prediction
Add
BLAST
Transmembranei42 – 6221Helical; Reviewed prediction
Add
BLAST
Transmembranei79 – 9921Helical; Reviewed prediction
Add
BLAST
Transmembranei107 – 12721Helical; Reviewed prediction
Add
BLAST
Transmembranei142 – 16221Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Reviewed prediction
Add
BLAST
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Undecaprenyl-diphosphatase 2UniRule annotation
PRO_0000151092Add
BLAST

Proteomic databases

PRIDEiQ81G27.

Interactioni

Protein-protein interaction databases

STRINGi226900.BC1384.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiWRKISSS.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81G27-1 [UniParc]FASTAAdd to Basket

« Hide

MADWLIGLIM GAVEGLTEFL PVSSTGHMIL TGHLIGFDDE RAKVFEVVIQ    50
LGSILAVVVI FWKRLWSLVG IGKVTDGPSL NLLHIIIGMI PAGVLGVLFH 100
STIKEGLFGP GPVVISLVAG GILMIVAEKF SKPSTARTLD EITYKQAFTI 150
GMFQCLALWP GFSRSGSTIS GGLLARVSHT AAAEYTFILA VPMMVAASGL 200
DLIKSWDVLS SADITLFVTG FVTAFVVAML AIVSFLKLLS RVKLTPFAYY 250
RFILAAVFYF FIM 263
Length:263
Mass (Da):28,355
Last modified:June 1, 2003 - v1
Checksum:iC978B87D89BB0266
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP08366.1.
RefSeqiNP_831165.1. NC_004722.1.
WP_000796255.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP08366; AAP08366; BC_1384.
GeneIDi1203733.
KEGGibce:BC1384.
PATRICi32598497. VBIBacCer54481_1358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP08366.1 .
RefSeqi NP_831165.1. NC_004722.1.
WP_000796255.1. NC_004722.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 226900.BC1384.

Proteomic databases

PRIDEi Q81G27.

Protocols and materials databases

DNASUi 1203733.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP08366 ; AAP08366 ; BC_1384 .
GeneIDi 1203733.
KEGGi bce:BC1384.
PATRICi 32598497. VBIBacCer54481_1358.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi WRKISSS.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BCER226900:GJEU-1384-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31.

Entry informationi

Entry nameiUPPP2_BACCR
AccessioniPrimary (citable) accession number: Q81G27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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