Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q81G27

- UPPP2_BACCR

UniProt

Q81G27 - UPPP2_BACCR

Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBCER226900:GJEU-1384-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 2UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
    Gene namesi
    Name:uppP2UniRule annotation
    Synonyms:bacA2, upk2
    Ordered Locus Names:BC_1384
    OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
    Taxonomic identifieri226900 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000001417: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Undecaprenyl-diphosphatase 2PRO_0000151092Add
    BLAST

    Proteomic databases

    PRIDEiQ81G27.

    Interactioni

    Protein-protein interaction databases

    STRINGi226900.BC1384.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3723HelicalUniRule annotationAdd
    BLAST
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei79 – 9921HelicalUniRule annotationAdd
    BLAST
    Transmembranei107 – 12721HelicalUniRule annotationAdd
    BLAST
    Transmembranei142 – 16221HelicalUniRule annotationAdd
    BLAST
    Transmembranei183 – 20321HelicalUniRule annotationAdd
    BLAST
    Transmembranei216 – 23621HelicalUniRule annotationAdd
    BLAST
    Transmembranei242 – 26221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    KOiK06153.
    OMAiWRKISSS.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q81G27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADWLIGLIM GAVEGLTEFL PVSSTGHMIL TGHLIGFDDE RAKVFEVVIQ    50
    LGSILAVVVI FWKRLWSLVG IGKVTDGPSL NLLHIIIGMI PAGVLGVLFH 100
    STIKEGLFGP GPVVISLVAG GILMIVAEKF SKPSTARTLD EITYKQAFTI 150
    GMFQCLALWP GFSRSGSTIS GGLLARVSHT AAAEYTFILA VPMMVAASGL 200
    DLIKSWDVLS SADITLFVTG FVTAFVVAML AIVSFLKLLS RVKLTPFAYY 250
    RFILAAVFYF FIM 263
    Length:263
    Mass (Da):28,355
    Last modified:June 1, 2003 - v1
    Checksum:iC978B87D89BB0266
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016877 Genomic DNA. Translation: AAP08366.1.
    RefSeqiNP_831165.1. NC_004722.1.
    WP_000796255.1. NC_004722.1.

    Genome annotation databases

    EnsemblBacteriaiAAP08366; AAP08366; BC_1384.
    GeneIDi1203733.
    KEGGibce:BC1384.
    PATRICi32598497. VBIBacCer54481_1358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016877 Genomic DNA. Translation: AAP08366.1 .
    RefSeqi NP_831165.1. NC_004722.1.
    WP_000796255.1. NC_004722.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226900.BC1384.

    Proteomic databases

    PRIDEi Q81G27.

    Protocols and materials databases

    DNASUi 1203733.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP08366 ; AAP08366 ; BC_1384 .
    GeneIDi 1203733.
    KEGGi bce:BC1384.
    PATRICi 32598497. VBIBacCer54481_1358.

    Phylogenomic databases

    eggNOGi COG1968.
    KOi K06153.
    OMAi WRKISSS.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BCER226900:GJEU-1384-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14579 / DSM 31.

    Entry informationi

    Entry nameiUPPP2_BACCR
    AccessioniPrimary (citable) accession number: Q81G27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3