Reviewed, UniProtKB/Swiss-Prot Q81G27 (UPPP2_BACCR)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Synonyms:	bacA2, upk2
Ordered Locus Names:	BC_1384

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000151092
Regions
	Transmembrane	15 – 37	23	Potential
	Transmembrane	42 – 62	21	Potential
	Transmembrane	79 – 99	21	Potential
	Transmembrane	107 – 127	21	Potential
	Transmembrane	142 – 162	21	Potential
	Transmembrane	183 – 203	21	Potential
	Transmembrane	216 – 236	21	Potential
	Transmembrane	242 – 262	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q81G27-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C978B87D89BB0266	FASTA	263	28,355
	10 20 30 40 50 60 MADWLIGLIM GAVEGLTEFL PVSSTGHMIL TGHLIGFDDE RAKVFEVVIQ LGSILAVVVI 70 80 90 100 110 120 FWKRLWSLVG IGKVTDGPSL NLLHIIIGMI PAGVLGVLFH STIKEGLFGP GPVVISLVAG 130 140 150 160 170 180 GILMIVAEKF SKPSTARTLD EITYKQAFTI GMFQCLALWP GFSRSGSTIS GGLLARVSHT 190 200 210 220 230 240 AAAEYTFILA VPMMVAASGL DLIKSWDVLS SADITLFVTG FVTAFVVAML AIVSFLKLLS 250 260 RVKLTPFAYY RFILAAVFYF FIM

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016877 Genomic DNA. Translation: AAP08366.1.
RefSeq	NP_831165.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q81G27.
Genome annotation databases
GeneID	1203733.
GenomeReviews	Gene locus BC_1384 in contig AE016877_GR.
KEGG	bce:BC1384.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	PERENVT.
Enzyme and pathway databases
BioCyc	BCER226900:BC_1384-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_BACCR

Accession

Primary (citable) accession number: Q81G27

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)