Reviewed, UniProtKB/Swiss-Prot Q81G13 (ILVC1_BACCR)

Names and origin

Protein names

Recommended name:
    Ketol-acid reductoisomerase 1
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase 1
    Alpha-keto-beta-hydroxylacil reductoisomerase 1

Gene names

Name:	ilvC1
Ordered Locus Names:	BC_1399

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Ketol-acid reductoisomerase 1		PRO_0000151274
Sites
	Active site	107	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q81G13-1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 3C5E8DAD4CCAD586	FASTA	336	36,649
	10 20 30 40 50 60 MAKVYYEKDV TVNVLKEKKV AIIGYGSQGH AHAQNLRDNG FDVVVGLRKG KSWDKANEDG 70 80 90 100 110 120 FSVYTVAEAA EKADVVMILL PDELQPEVYE AEIAPNLQAG NSLVFAHGFN VHFDQVKPPA 130 140 150 160 170 180 NVDVFLVAPK GPGHLVRRTF AEGGAVPALF AVYQDATGVA TEKALSYADG IGATRAGVLE 190 200 210 220 230 240 TTFKEETETD LFGEQAVLCG GVTALVKAGF ETLVDAGYQP ELAYFECLHE LKLIVDLMYE 250 260 270 280 290 300 GGLENMRYSV SDTAQWGDFV SGPRVVTEDT KKAMGAVLAE IQDGTFARGW IAEHKAGRPN 310 320 330 FHATNEKENK HEIEVVGRKL REMMPFVQPR VKVGVK

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016877 Genomic DNA. Translation: AAP08380.1. Different initiation.
RefSeq	NP_831179.1.
3D structure databases
HSSP	HSSP built from PDB template 1NP3 based on UniProtKB Q9HVA2.
ModBase	Search...
Genome annotation databases
GeneID	1203748.
GenomeReviews	Gene locus BC_1399 in contig AE016877_GR.
KEGG	bce:BC1399.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q81G13.
Enzyme and pathway databases
BioCyc	BCER226900:BC_1399-MON.
Family and domain databases
HAMAP	MF_00435. [Tree]
InterPro	IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00465. ilvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC1_BACCR

Accession

Primary (citable) accession number: Q81G13

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 17, 2006
Last modified:	November 25, 2008
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)