Q81G00 (HIS2_BACCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-ATP pyrophosphatase
Short name=PRA-PH
EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	BC_1412

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31)

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 107

107

Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020

PRO_0000136345

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

107

Helix Strand Turn

Details...

Helix

5 – 17

13

Helix

24 – 31

8

Helix

33 – 52

20

Helix

56 – 76

21

Helix

81 – 94

14

Sequences

	Sequence		Length	Mass (Da)
	Q81G00 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A2B1899D636C7316	FASTA	107	12,446
	10 20 30 40 50 60 MENAFKLLYK TIEERKGSPL PESYTNYLFS KGEDKILKKI GEECAEVIIA CKNNDKEEVV 70 80 90 100 KEMVDVFYHC FVLLAEKNIA LEDVMREVKE RNGKLSRVGD RREIDTL

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 14579 / DSM 31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016877 Genomic DNA. Translation: AAP08393.1.

RefSeq

NP_831192.1. NC_004722.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YVW	X-ray	2.60	A/B/C/D	1-107	[»]

ProteinModelPortal

Q81G00.

SMR

Q81G00. Positions 4-95.

ModBase

Search...

Protein-protein interaction databases

STRING

Q81G00.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBBACT00000034469; EBBACP00000033675; EBBACG00000034460.

GeneID

1203761.

GenomeReviews

Gene locus BC_1412 in contig AE016877_GR.

KEGG

bce:BC1412.

PATRIC

32598560. VBIBacCer54481_1389.

Phylogenomic databases

eggNOG

COG0140.

GeneTree

EBGT00050000000893.

HOGENOM

HBG646527.

OMA

EMRRREN.

ProtClustDB

PRK00400.

Enzyme and pathway databases

BioCyc

BCER226900:BC_1412-MONOMER.

Family and domain databases

HAMAP

MF_01020. HisE.
[Tree]

InterPro

IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
[Graphical view]

KO

K01523.

Pfam

PF01503. PRA-PH. 1 hit.
[Graphical view]

TIGRFAMs

TIGR03188. Histidine_hisI. 1 hit.

ProtoNet

Search...

Entry information

Entry name

HIS2_BACCR

Accession

Primary (citable) accession number: Q81G00

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program