Reviewed, UniProtKB/Swiss-Prot Q81FQ2 (AROB_BACCR)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BC_1517

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	NAD By similarity. Divalent metal cations By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000140708

Sequences

	Sequence		Length	Mass (Da)
	Q81FQ2-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E456B4259AA53ED1	FASTA	361	39,974
	10 20 30 40 50 60 MGNIHIQTKS KEYDVHVGKE VLSNLTTIVQ NMQPAVSNVM IISDEAVASL HLQTVIDALQ 70 80 90 100 110 120 VEQHVFSFVV PSGEKEKSFE NFYAAHTSAL ENKLDRNSLI LALGGGMIGD LAGFVAASFM 130 140 150 160 170 180 RGIRFVQVPT TLLAHDSAVG GKVAINHPLG KNMIGAFHQP EAVVYHTPFL QSLPEKEWRS 190 200 210 220 230 240 GYAEVIKHAL IGDVELYHWL KEEVQTLADL HDEKLIHILT KAIPVKANVV SQDETEKGVR 250 260 270 280 290 300 AHLNFGHTLG HALEKELGYG NITHGDGVAV GMLFAIFLSE QVYKVDLAYE DMKQWFLKYG 310 320 330 340 350 360 YPKMPGDLNV ERIVQLMKQD KKANAGAIHM VLMQEYGVVN VVSISDETVH IALEAFQKDM V

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016877 Genomic DNA. Translation: AAP08497.1.
RefSeq	NP_831296.1.
3D structure databases
HSSP	HSSP built from PDB template 1DQS based on UniProtKB P07547.
ModBase	Search...
Protein-protein interaction databases
STRING	Q81FQ2.
Genome annotation databases
GeneID	1203866.
GenomeReviews	Gene locus BC_1517 in contig AE016877_GR.
KEGG	bce:BC1517.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q81FQ2.
OMA	KANIVAQ.
Enzyme and pathway databases
BioCyc	BCER226900:BC_1517-MON.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BACCR

Accession

Primary (citable) accession number: Q81FQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)