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Q81F42

- FABH2_BACCR

UniProt

Q81F42 - FABH2_BACCR

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Protein
3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2
Gene
fabH2, BC_1760
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141 By similarity
Active sitei251 – 2511 By similarity
Active sitei281 – 2811 By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
  2. beta-ketoacyl-acyl-carrier-protein synthase III activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBCER226900:GJEU-1760-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 (EC:2.3.1.180)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III protein 2
Beta-ketoacyl-ACP synthase III 2
Short name:
KAS III 2
Gene namesi
Name:fabH2
Ordered Locus Names:BC_1760
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3273273-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2UniRule annotation
PRO_0000110396Add
BLAST

Proteomic databases

PRIDEiQ81F42.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi226900.BC1760.

Structurei

3D structure databases

ProteinModelPortaliQ81F42.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 2565ACP-binding By similarity

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.

Phylogenomic databases

eggNOGiCOG0332.
KOiK00648.
OMAiDWFVPHS.
OrthoDBiEOG6J74XN.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01815. FabH.
InterProiIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
TIGRFAMsiTIGR00747. fabH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81F42-1 [UniParc]FASTAAdd to Basket

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MHSKSRITAI GTYVPDQILS NNDLEKMVHT NDEWIVQRTG MRERRIASEE    50
EYSSNLAIKA IENLCTTYKK NLEDVDCIIV ATTTADYVFP SVACQIQQYF 100
NIPHTLAFDL NATCAGFTYG LHVGNSLITS ESHEKVLVVA TETLSKVTDY 150
TDRTTCILFG DGAGAILLER DENTPSFIAA HMGTNGDGGI HLYRTNLSTT 200
MNGTPLQTNE KIVQNGREVY KWATRTVPKG IKNLLHTVNM QVDDIDWFIP 250
HSANLRMIES ICEKSQIPIQ KTLTSVEYMG NTSSVTIPLA LNLAIKEGKL 300
NNGDTLLLYG FGGGLTHLGL IVEWNLI 327
Length:327
Mass (Da):36,247
Last modified:June 1, 2003 - v1
Checksum:i8C03B6E178732409
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP08736.1.
RefSeqiNP_831535.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP08736; AAP08736; BC_1760.
GeneIDi1204109.
KEGGibce:BC1760.
PATRICi32599281. VBIBacCer54481_1749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP08736.1 .
RefSeqi NP_831535.1. NC_004722.1.

3D structure databases

ProteinModelPortali Q81F42.
ModBasei Search...

Protein-protein interaction databases

STRINGi 226900.BC1760.

Proteomic databases

PRIDEi Q81F42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP08736 ; AAP08736 ; BC_1760 .
GeneIDi 1204109.
KEGGi bce:BC1760.
PATRICi 32599281. VBIBacCer54481_1749.

Phylogenomic databases

eggNOGi COG0332.
KOi K00648.
OMAi DWFVPHS.
OrthoDBi EOG6J74XN.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci BCER226900:GJEU-1760-MONOMER.