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Q81F26 (ILVD_BACCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:BC_1780
OrganismBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifier226900 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence caution

The sequence AAP08754.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Dihydroxy-acid dehydratase HAMAP MF_00012
PRO_0000103429

Sites

Metal binding1191Iron-sulfur (4Fe-4S) Potential
Metal binding1921Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q81F26 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: EAB5CD9E97716E5C

FASTA55760,079
        10         20         30         40         50         60 
MRSDMIKKGF DKAPHRSLLK ATGLKDEDFD KPFIAICNSF IEIIPGHKHL NEFGKLVKEA 

        70         80         90        100        110        120 
VRAAGMVPFE FNTIGVDDGI AMGHIGMRYS LPSREIIADS VETVVNAHWF DGMICIPNCD 

       130        140        150        160        170        180 
KITPGMMMAA LRINIPTVFV SGGPMAAGKT SKGEVVDLSS VFEGVGAYQS GKISEEELKD 

       190        200        210        220        230        240 
IEDHGCPSCG SCSGMFTANS MNCLCEVLGL ALPGNGSILA IDPRREELIK QAAEKLKILI 

       250        260        270        280        290        300 
ERDIKPRDIV TEEAIDDAFA LDMAMGGSTN TVLHTLALAQ EAGLDYDMNR IDAVSRRVPH 

       310        320        330        340        350        360 
LCKVSPASNW HMEDIDRAGG ISAILKEMSR KEGVLHLDRI TATGQTLREN IAEAEIKDKE 

       370        380        390        400        410        420 
VIHSLENPHS EEGGLRILKG NLAKDGAVIK SGATEVKRFE GPCVIFNSQD EALAGIMLGK 

       430        440        450        460        470        480 
VKKGDVVVIR YEGPRGGPGM PEMLAPTSAI AGMGLGAEVA LLTDGRFSGA SRGISVGHIS 

       490        500        510        520        530        540 
PEAAAGGMIA LLEQGDIVCI DVEERLLEVR VSDEELEKRK KEWKRPEPKV KTGWLGRYAQ 

       550 
MVTSANTGAV LKIPHFD

« Hide

References

[1]"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis."
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. expand/collapse author list , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
Nature 423:87-91(2003) [PubMed: 12721630] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14579 / DSM 31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016877 Genomic DNA. Translation: AAP08754.1. Different initiation.
RefSeqNP_831553.1. NC_004722.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ81F26.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000033490; EBBACP00000032696; EBBACG00000033481.
GeneID1204129.
GenomeReviewsGene locus BC_1780 in contig AE016877_GR.
KEGGbce:BC1780.
PATRIC32599325. VBIBacCer54481_1771.

Phylogenomic databases

eggNOGCOG0129.
GeneTreeEBGT00050000001430.
HOGENOMHBG671001.
OMASQDCRWP.
PhylomeDBQ81F26.
ProtClustDBPRK00911.

Enzyme and pathway databases

BioCycBCER226900:BC_1780-MONOMER.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_BACCR
AccessionPrimary (citable) accession number: Q81F26
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: May 24, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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