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Reviewed, UniProtKB/Swiss-Prot Q81EF6 (NAMA_BACCR)

Last modified November 25, 2008. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADPH dehydrogenase
    EC=1.6.99.1
Alternative name(s):
    Xenobiotic reductase
Gene names
Name: namA
Ordered Locus Names: BC_2023
OrganismBacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]
Taxonomic identifier226900 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the reduction of the double bond of an array of alpha, beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity.

Catalytic activity

NADPH + acceptor = NADP(+) + reduced acceptor.

Cofactor

FMN By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.

Ontologies

Keywords

   LigandFMN
Flavoprotein
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

NADPH dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345NADPH dehydrogenase
PRO_0000216114

Regions

Nucleotide binding23 – 275FMN By similarity

Sites

Binding site281Substrate By similarity
Binding site1641Substrate By similarity
Binding site1671Substrate By similarity
Binding site2151FMN By similarity
Binding site3081FMN By similarity

Sequences

Sequence LengthMass (Da)Tools
Q81EF6-1 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: 77A2907FB25678FD

FASTA34538,582
        10         20         30         40         50         60 
MNSKLFSPYT IKNVTLKNRI VMSPMCMYSS GNEDGRVTNF HLIHYGTRAA GQVGLVMVEA 

        70         80         90        100        110        120 
TAVLAEGRIS NNDLGIWDDN LIEGLHKTTT FIHDNGAKAA IQLAHAGRKA ELDTNAFAPS 

       130        140        150        160        170        180 
AIPFNDKMKI PVEMNIQQIK ETILAFQRAA LRSKQAGFDV IELHGAHGYL INEFLSPLTN 

       190        200        210        220        230        240 
KRTDKYGGSP ENRYRFLREI IDSVNEVWDG PIFVRISAND YHPDGLTVQD YVQYTKWMKE 

       250        260        270        280        290        300 
QGIDLIDCSS GAVVPAHIDV YPGYQVQYAK HIKEHTNIAT GAVGLITTGS QAEQILNNNE 

       310        320        330        340 
ADLIFIGREL LRNPYFPRIA ANELGFELQE PHQYKRAPGK IHTNK 

« Hide

References

[1]"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis."
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. expand/collapse author list , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
Nature 423:87-91(2003) [PubMed: 12721630] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AE016877 Genomic DNA. Translation: AAP08992.1. Different initiation.
RefSeqNP_831791.1.

3D structure databases

HSSPHSSP built from PDB template 1GWJ based on UniProtKB Q51990.
ModBaseSearch...

Genome annotation databases

GeneID1204372.
GenomeReviewsGene locus BC_2023 in contig AE016877_GR.
KEGGbce:BC2023.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ81EF6.

Enzyme and pathway databases

BioCycBCER226900:BC_2023-MON.

Family and domain databases

HAMAPMF_01614.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAMA_BACCR
AccessionPrimary (citable) accession number: Q81EF6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 25, 2008
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents