Reviewed,
UniProtKB/Swiss-Prot Q81EF6 (NAMA_BACCR)
Last modified
January 19, 2010.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADPH dehydrogenase EC=1.6.99.1 Alternative name(s): Xenobiotic reductase | ||||
| Gene names |
| ||||
| Organism | Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 226900 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 345 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the reduction of the double bond of an array of alpha, beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity. HAMAP MF_01614 |
| Catalytic activity | NADPH + acceptor = NADP+ + reduced acceptor. HAMAP MF_01614 |
| Cofactor | FMN By similarity. HAMAP MF_01614 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_01614 |
| Sequence similarities | Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FMN Flavoprotein NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | FMN binding Inferred from electronic annotation. Source: InterPro NADPH dehydrogenase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 345 | 345 | NADPH dehydrogenase HAMAP MF_01614 | PRO_0000216114 | |||||
Regions | |||||||||
| Nucleotide binding | 23 – 27 | 5 | FMN By similarity | ||||||
Sites | |||||||||
| Binding site | 28 | 1 | Substrate By similarity | ||||||
| Binding site | 164 | 1 | Substrate By similarity | ||||||
| Binding site | 167 | 1 | Substrate By similarity | ||||||
| Binding site | 215 | 1 | FMN By similarity | ||||||
| Binding site | 308 | 1 | FMN By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. Kyrpides N.C.Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016877 Genomic DNA. Translation: AAP08992.1. Different initiation. |
| RefSeq | NP_831791.1. |
3D structure databases | |
| SMR | Q81EF6. Positions 4-337. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q81EF6. |
Genome annotation databases | |
| GeneID | 1204372. |
| GenomeReviews | Gene locus BC_2023 in contig AE016877_GR. |
| KEGG | bce:BC2023. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1902. |
| HOGENOM | HBG583461. |
| OMA | HILRTGQ. |
Enzyme and pathway databases | |
| BioCyc | BCER226900:BC_2023-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01614. NamA. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR001155. OxRdtase_FMN_N. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF00724. Oxidored_FMN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NAMA_BACCR | ||||||||
| Accession | Primary (citable) accession number: Q81EF6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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