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Q81E87

- FTHS_BACCR

UniProt

Q81E87 - FTHS_BACCR

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, BC_2101
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 788ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCER226900:GJEU-2101-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:BC_2101
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199329Add
BLAST

Proteomic databases

PRIDEiQ81E87.

Interactioni

Protein-protein interaction databases

STRINGi226900.BC2101.

Structurei

3D structure databases

ProteinModelPortaliQ81E87.
SMRiQ81E87. Positions 10-560.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81E87-1 [UniParc]FASTAAdd to Basket

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MTTTTTVKSD IEIAQEASMK KIQEIAADLN ILEDELEPYG HYKGKLSLDI    50
FKRLQDEKDG KVVLVTAINP TPAGEGKSTV TVGLGQAFNK IGKKTVIALR 100
EPSLGPTMGL KGGAAGGGFS QVVPMEDINL HFTGDIHAIT TANNALAAFI 150
DNHIQQGNTL GIDTRKIVWK RCVDLNDRAL RNVVIGLGGP VQGVPREDGF 200
DITVASEIMA VFCLATDIQD LKARLSRIVV AYNFANQPVT VKDLGVEGAL 250
TLLLKDALKP NLVQTLENTP AIIHGGPFAN IAHGCNSVIA TTMAAKLGDY 300
VITEAGFGAD LGAEKFLDIK ARAAGIKPEA VVIVATIRAL KMHGGVAKDQ 350
LKEENVDALA KGMENLQKHV ETIQSFGVPF VIAINKFITD TDAEVTYLQE 400
WCNERGYAVS LTEVWEKGGQ GGVDLAEKVL KEIEKGENNY APLYELELPL 450
EEKIRTIAQK VYGAKDIEFA PKARKQLAQY EGEGWSNLPV CMAKTQYSLS 500
DDVTKLGRPS DFIVTIRELK PSIGAGFIVA LTGTMLTMPG LPKQPAALQM 550
DVNEDGKAVG LF 562
Length:562
Mass (Da):60,507
Last modified:June 1, 2003 - v1
Checksum:i973BABE7BF7475D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP09070.1.
RefSeqiNP_831869.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP09070; AAP09070; BC_2101.
GeneIDi1204450.
KEGGibce:BC2101.
PATRICi32600016. VBIBacCer54481_2116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP09070.1 .
RefSeqi NP_831869.1. NC_004722.1.

3D structure databases

ProteinModelPortali Q81E87.
SMRi Q81E87. Positions 10-560.
ModBasei Search...

Protein-protein interaction databases

STRINGi 226900.BC2101.

Proteomic databases

PRIDEi Q81E87.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP09070 ; AAP09070 ; BC_2101 .
GeneIDi 1204450.
KEGGi bce:BC2101.
PATRICi 32600016. VBIBacCer54481_2116.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BCER226900:GJEU-2101-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31.

Entry informationi

Entry nameiFTHS_BACCR
AccessioniPrimary (citable) accession number: Q81E87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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