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Protein

Kynurenine formamidase

Gene

kynB

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation1 Publication

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation1 Publication

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA)
  2. Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

  • arylformamidase activity Source: UniProtKB
  • formamidase activity Source: InterPro

GO - Biological processi

  • anthranilate metabolic process Source: UniProtKB
  • tryptophan catabolic process to kynurenine Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processTryptophan catabolism

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:BC_2758
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003620911 – 209Kynurenine formamidaseAdd BLAST209

Interactioni

Protein-protein interaction databases

STRINGi226900.BC2758

Structurei

3D structure databases

ProteinModelPortaliQ81CK1
SMRiQ81CK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cyclase 1 superfamily. KynB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107VWA Bacteria
COG1878 LUCA
KOiK07130
OMAiPSWESDG

Family and domain databases

Gene3Di3.50.30.50, 1 hit
HAMAPiMF_01969 KynB, 1 hit
InterProiView protein in InterPro
IPR007325 KFase
IPR037175 KFase_sf
IPR017484 Kynurenine_formamidase_bac
PfamiView protein in Pfam
PF04199 Cyclase, 1 hit
SUPFAMiSSF102198 SSF102198, 1 hit
TIGRFAMsiTIGR03035 trp_arylform, 1 hit

Sequencei

Sequence statusi: Complete.

Q81CK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSEWIDIS QPLNNNIATW PGDTPFSYEV SWSKEESGSV NVGKLTMSIH
60 70 80 90 100
TGTHIDAPFH FDNDGKKVLD LDVQVYVGPA RIIDVSNLES IGKKELESFH
110 120 130 140 150
LEGVERLLLR TSSHGKAEEF PEVIPHLRAD IASFLSEKGI RLIGVDVPSV
160 170 180 190 200
DPLDDKELAA HHQLFKHGIH ILENVVLDHV ADGDYELIAL PLALTDADGS

PVRAVIRPI
Length:209
Mass (Da):23,066
Last modified:June 1, 2003 - v1
Checksum:i54270A35415116A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA Translation: AAP09711.1
RefSeqiNP_832510.1, NC_004722.1
WP_000858074.1, NC_004722.1

Genome annotation databases

EnsemblBacteriaiAAP09711; AAP09711; BC_2758
GeneIDi1205106
KEGGibce:BC2758
PATRICifig|226900.8.peg.2813

Similar proteinsi

Entry informationi

Entry nameiKYNB_BACCR
AccessioniPrimary (citable) accession number: Q81CK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health