Reviewed, UniProtKB/Swiss-Prot Q81CK1 (KYNB_BACCR)

Names and origin

Protein names

Recommended name:
    Kynurenine formamidase
      Short name=KFA
    EC=3.5.1.9
Alternative name(s):
    N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	BC_2758

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine. Ref.2
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine. Ref.2
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Ref.2 Inferred from Genomic Context. Source: UniProtKB tryptophan catabolic process to kynurenine Ref.2 Inferred from Genomic Context. Source: UniProtKB
Molecular function	arylformamidase activity Ref.2 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Kynurenine formamidase		PRO_0000362091

Sequences

	Sequence		Length	Mass (Da)
	Q81CK1-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 54270A35415116A0	FASTA	209	23,066
	10 20 30 40 50 60 MKTSEWIDIS QPLNNNIATW PGDTPFSYEV SWSKEESGSV NVGKLTMSIH TGTHIDAPFH 70 80 90 100 110 120 FDNDGKKVLD LDVQVYVGPA RIIDVSNLES IGKKELESFH LEGVERLLLR TSSHGKAEEF 130 140 150 160 170 180 PEVIPHLRAD IASFLSEKGI RLIGVDVPSV DPLDDKELAA HHQLFKHGIH ILENVVLDHV 190 200 ADGDYELIAL PLALTDADGS PVRAVIRPI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase." Kurnasov O., Jablonski L., Polanuyer B., Dorrestein P., Begley T., Osterman A. FEMS Microbiol. Lett. 227:219-227(2003) [PubMed: 14592712] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016877 Genomic DNA. Translation: AAP09711.1.
RefSeq	NP_832510.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q81CK1.
Genome annotation databases
GeneID	1205106.
GenomeReviews	Gene locus BC_2758 in contig AE016877_GR.
KEGG	bce:BC2758.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q81CK1.
OMA	WPGDTPF.
Enzyme and pathway databases
BioCyc	BCER226900:BC_2758-MON.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BACCR

Accession

Primary (citable) accession number: Q81CK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)