Reviewed, UniProtKB/Swiss-Prot Q81C42 (AROC2_BACCR)

Names and origin

Protein names

Recommended name:
    Chorismate synthase 2
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase 2

Gene names

Name:	aroC2
Ordered Locus Names:	BC_2941

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Chorismate synthase 2 HAMAP MF_00300		PRO_0000140544

Sequences

	Sequence		Length	Mass (Da)
	Q81C42-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0D2CD2121C74363D	FASTA	390	42,404
	10 20 30 40 50 60 MRYITAGESH GPQLTVILEG VPAGLTLTAE HINKELLRRQ KGHGRGRRMQ IETDTVEIVS 70 80 90 100 110 120 GVRHGMTLGS PITLIVKNDD FKHWTKVMGA EPISEKESKD MKRTITKPRP GHADLNGAIK 130 140 150 160 170 180 YGHRDIRNVL ERSSARETTV RVAAGAVAKQ ILSELGVEIA GHVLEIGGVK AKHISNLSIE 190 200 210 220 230 240 EIQTITENSP VRCLDKEVEQ EMMNAIDNAK SSGDSIGGIV EVIAEGMPIG VGSYVHYDRK 250 260 270 280 290 300 LDAKLAGAIM SINAFKGAEI GVGFEAARQP GSKVHDEILW DEEKGYTRRT NNAGGLEGGM 310 320 330 340 350 360 TTGMPIIVRG VMKPIPTLYK PLASVDIDTK EAFQASIERS DSCAVPAAGV VAESVVAWEL 370 380 390 ADALVEQFGK DRMELLKQNI MQHNNYAKEF

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016877 Genomic DNA. Translation: AAP09889.1.
RefSeq	NP_832688.1.
3D structure databases
SMR	Q81C42. Positions 1-390.
ModBase	Search...
Protein-protein interaction databases
STRING	Q81C42.
Genome annotation databases
GeneID	1205289.
GenomeReviews	Gene locus BC_2941 in contig AE016877_GR.
KEGG	bce:BC2941.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
OMA	WELAHAL.
Enzyme and pathway databases
BioCyc	BCER226900:BC_2941-MONOMER.
Family and domain databases
HAMAP	MF_00300_B. Chorismate_synth_B. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC2_BACCR

Accession

Primary (citable) accession number: Q81C42

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)