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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei80UniRule annotation1
Active sitei143UniRule annotation1
Active sitei167UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:BC_3063
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847091 – 215Pyrrolidone-carboxylate peptidaseAdd BLAST215

Proteomic databases

PRIDEiQ81BT3.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi226900.BC3063.

Structurei

3D structure databases

ProteinModelPortaliQ81BT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KN7. Bacteria.
COG2039. LUCA.
KOiK01304.
OMAiNINPAWE.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81BT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTVLLTGFD PFGGENINPA WEVAKGLHEK TIGEYKIISK QVPTVFHKSI
60 70 80 90 100
SVLKEYIEEL APEIIICIGQ AGGRPDITIE RVAINIDDAR IADNEGNQPV
110 120 130 140 150
DVPVVEEGVI AYWSTLPMKA IVKKLREEGI PSSVSQTAGT FVCNHLFYGL
160 170 180 190 200
MHELEKHDKK IKGGFIHIPF LPEQASNYPG QPSMSLSTIR KGIELAIEVT
210
TTVKVDIVEV GGATH
Length:215
Mass (Da):23,556
Last modified:June 1, 2003 - v1
Checksum:iBDF3B24089A5EFB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP10010.1.
RefSeqiNP_832809.1. NC_004722.1.
WP_000859710.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP10010; AAP10010; BC_3063.
GeneIDi1205411.
KEGGibce:BC3063.
PATRICi32602067. VBIBacCer54481_3138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP10010.1.
RefSeqiNP_832809.1. NC_004722.1.
WP_000859710.1. NC_004722.1.

3D structure databases

ProteinModelPortaliQ81BT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226900.BC3063.

Protein family/group databases

MEROPSiC15.001.

Proteomic databases

PRIDEiQ81BT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP10010; AAP10010; BC_3063.
GeneIDi1205411.
KEGGibce:BC3063.
PATRICi32602067. VBIBacCer54481_3138.

Phylogenomic databases

eggNOGiENOG4108KN7. Bacteria.
COG2039. LUCA.
KOiK01304.
OMAiNINPAWE.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCP_BACCR
AccessioniPrimary (citable) accession number: Q81BT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.