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Q81BK3

- ARSC_BACCR

UniProt

Q81BK3 - ARSC_BACCR

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Protein
Protein ArsC
Gene
arsC, BC_3152
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111Nucleophile; for reductase activity and phosphatase activity By similarity
Active sitei83 – 831Nucleophile; for reductase activity By similarity
Active sitei90 – 901Nucleophile; for reductase activity By similarity

GO - Molecular functioni

  1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
  2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to arsenic-containing substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciBCER226900:GJEU-3150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsC
Alternative name(s):
Arsenate reductase (EC:1.20.4.-)
Arsenical pump modifier
Low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
Gene namesi
Name:arsC
Ordered Locus Names:BC_3152
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Protein ArsCUniRule annotation
PRO_0000162514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi11 ↔ 83Redox-active; alternate By similarity
Disulfide bondi83 ↔ 90Redox-active; alternate By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi226900.BC3152.

Structurei

3D structure databases

ProteinModelPortaliQ81BK3.
SMRiQ81BK3. Positions 1-134.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0394.
KOiK03741.
OMAiGDRYEAY.
OrthoDBiEOG6JDWJC.

Family and domain databases

HAMAPiMF_01624. Arsenate_reduct.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717. PTHR11717. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81BK3-1 [UniParc]FASTAAdd to Basket

« Hide

MENKKTIYFL CTGNSCRSQM AEAWGKQYLG DKWNVYSAGM EAHGVNPNAI    50
KAMNEVNIDI TNQTSDIIDA NILNSADLVV TLCSHADSVC PSTPPHVNRV 100
HWGFDDPAGK EWSEFQRVRD EIGERIKRFS KTGE 134
Length:134
Mass (Da):15,020
Last modified:June 1, 2003 - v1
Checksum:iD50182339306175D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP10094.1.
RefSeqiNP_832893.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP10094; AAP10094; BC_3152.
GeneIDi1205499.
KEGGibce:BC3152.
PATRICi32602259. VBIBacCer54481_3234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP10094.1 .
RefSeqi NP_832893.1. NC_004722.1.

3D structure databases

ProteinModelPortali Q81BK3.
SMRi Q81BK3. Positions 1-134.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226900.BC3152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP10094 ; AAP10094 ; BC_3152 .
GeneIDi 1205499.
KEGGi bce:BC3152.
PATRICi 32602259. VBIBacCer54481_3234.

Phylogenomic databases

eggNOGi COG0394.
KOi K03741.
OMAi GDRYEAY.
OrthoDBi EOG6JDWJC.

Enzyme and pathway databases

BioCyci BCER226900:GJEU-3150-MONOMER.

Family and domain databases

HAMAPi MF_01624. Arsenate_reduct.
InterProi IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717. PTHR11717. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31.

Entry informationi

Entry nameiARSC_BACCR
AccessioniPrimary (citable) accession number: Q81BK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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