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Protein

Histidine--tRNA ligase 1

Gene

hisS-1

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCER226900:GJEU-3315-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase 1UniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetase 1UniRule annotation
Short name:
HisRS 1UniRule annotation
Gene namesi
Name:hisS-1UniRule annotation
Ordered Locus Names:BC_3317
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Histidine--tRNA ligase 1PRO_0000136097Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi226900.BC3317.

Structurei

3D structure databases

ProteinModelPortaliQ81B71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiNKIKRAC.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81B71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEMRNVKGT KDYLPEEQVL RNKIKRACED TFERYGCKPL ETPTLNMYEL
60 70 80 90 100
MSYKYGGGDE ILKEIYTLQD QGKRELALRY DLTIPFAKVV AMNPNLRLPF
110 120 130 140 150
KRYEIGKVFR DGPIKQGRFR EFIQCDVDIV GVESVMAEAE LMAMAFELFR
160 170 180 190 200
TLNLEITIQY NNRKLLNGIL ESINIPTELT SDVILSLDKI EKIGIDGVRK
210 220 230 240 250
DVLERGISEE MADTICNTVL SCLKLTIADF KEAFNNPLVA DGVNELQQLQ
260 270 280 290 300
QYLIALGINE NTIFNPFLAR GLTMYTGTVY EIFLKDRSIT SSIGSGGRYD
310 320 330 340 350
NIIGAFRGDN MNYPTVGISF GLDVIYTALS QKETISSTAD VFIIPLGTEL
360 370 380 390 400
QCLQIAQQLR STTSLKVELE LAGRKLKRAL NYANKENIPY VLIIGEDELS
410 420
TNTVVLRNMK EGSEVKVPIS SLSRYL
Length:426
Mass (Da):48,144
Last modified:June 1, 2003 - v1
Checksum:i4DB7E3D889D43C30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP10257.1.
RefSeqiNP_833056.1. NC_004722.1.
WP_011110254.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP10257; AAP10257; BC_3317.
GeneIDi1205664.
KEGGibce:BC3317.
PATRICi32602595. VBIBacCer54481_3402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP10257.1.
RefSeqiNP_833056.1. NC_004722.1.
WP_011110254.1. NC_004722.1.

3D structure databases

ProteinModelPortaliQ81B71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226900.BC3317.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP10257; AAP10257; BC_3317.
GeneIDi1205664.
KEGGibce:BC3317.
PATRICi32602595. VBIBacCer54481_3402.

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiNKIKRAC.
OrthoDBiEOG6BPDH4.

Enzyme and pathway databases

BioCyciBCER226900:GJEU-3315-MONOMER.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711.

Entry informationi

Entry nameiSYH1_BACCR
AccessioniPrimary (citable) accession number: Q81B71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.