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Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase 1

Gene

dxr1

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: isopentenyl diphosphate biosynthesis via DXP pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1 (dxr1), 1-deoxy-D-xylulose 5-phosphate reductoisomerase 2 (dxr2)
  2. 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD)
  3. 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE)
  4. 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF)
  5. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG)
  6. no protein annotated in this organism
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via DXP pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate, the pathway isopentenyl diphosphate biosynthesis via DXP pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231SubstrateUniRule annotation
Metal bindingi148 – 1481Divalent metal cationUniRule annotation
Metal bindingi150 – 1501Divalent metal cationUniRule annotation
Binding sitei150 – 1501SubstrateUniRule annotation
Binding sitei174 – 1741SubstrateUniRule annotation
Binding sitei197 – 1971SubstrateUniRule annotation
Metal bindingi219 – 2191Divalent metal cationUniRule annotation
Binding sitei219 – 2191SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3730NADPUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Metal-binding, NADP

Enzyme and pathway databases

BioCyciBCER226900:GJEU-3339-MONOMER.
UniPathwayiUPA00056; UER00092.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase 1UniRule annotation (EC:1.1.1.267UniRule annotation)
Short name:
DXP reductoisomerase 1UniRule annotation
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase 1UniRule annotation
2-C-methyl-D-erythritol 4-phosphate synthase 1UniRule annotation
Gene namesi
Name:dxr1UniRule annotation
Ordered Locus Names:BC_3341
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3853851-deoxy-D-xylulose 5-phosphate reductoisomerase 1PRO_0000163603Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226900.BC3341.

Structurei

3D structure databases

ProteinModelPortaliQ81B49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEA. Bacteria.
COG0743. LUCA.
KOiK00099.
OMAiFIDGSVM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00183. DXP_reductoisom. 1 hit.
InterProiIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR30525. PTHR30525. 1 hit.
PfamiPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF69055. SSF69055. 1 hit.
TIGRFAMsiTIGR00243. Dxr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81B49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKYISILGS TGSIGTSALD VVSAHPEHFK IVGLTANYNI DLLEQQIKTF
60 70 80 90 100
QPRIVSVATK DLADKLRTRI SANTKITHGT DGFIAVATHP DSNLVLSSVV
110 120 130 140 150
GVSGLLPTIE ALKAKKDIAI ANKETLVAAG HIVTELAKQN GCRLIPVDSE
160 170 180 190 200
HSAIFQCLKG ENNKEIEKLI VTASGGAFRD KTRDEMQTLQ AKDALKHPNW
210 220 230 240 250
LMGAKLTIDS ATLMNKGFEV MEARWLFDIP YKKINVMIHK ESIIHSLVEF
260 270 280 290 300
IDGSVMAQLG APDMRMPIQY AFHYPTRLPS SYEKLNLLEI GSLHFEKPDL
310 320 330 340 350
EKFPCLQYAY ECGKIGGTTP AVLNAANEIA NALFLKNEIA FFDIEKTIYK
360 370 380
TVEAHHNVKD PSLDAILEAD QWARQYANEL LIKKR
Length:385
Mass (Da):42,624
Last modified:June 1, 2003 - v1
Checksum:i90ADA00BA0CD7315
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP10281.1.
RefSeqiNP_833080.1. NC_004722.1.
WP_000241785.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP10281; AAP10281; BC_3341.
GeneIDi1205688.
KEGGibce:BC3341.
PATRICi32602643. VBIBacCer54481_3426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP10281.1.
RefSeqiNP_833080.1. NC_004722.1.
WP_000241785.1. NC_004722.1.

3D structure databases

ProteinModelPortaliQ81B49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226900.BC3341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP10281; AAP10281; BC_3341.
GeneIDi1205688.
KEGGibce:BC3341.
PATRICi32602643. VBIBacCer54481_3426.

Phylogenomic databases

eggNOGiENOG4105CEA. Bacteria.
COG0743. LUCA.
KOiK00099.
OMAiFIDGSVM.

Enzyme and pathway databases

UniPathwayiUPA00056; UER00092.
BioCyciBCER226900:GJEU-3339-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00183. DXP_reductoisom. 1 hit.
InterProiIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR30525. PTHR30525. 1 hit.
PfamiPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF69055. SSF69055. 1 hit.
TIGRFAMsiTIGR00243. Dxr. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDXR1_BACCR
AccessioniPrimary (citable) accession number: Q81B49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.