Reviewed, UniProtKB/Swiss-Prot Q81AZ5 (SPX2_BACCR)

Names and origin

Protein names

Recommended name:
    Regulatory protein spx 2

Gene names

Name:	spxA2
Ordered Locus Names:	BC_3402

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the arsC family. Spx subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription regulator activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Regulatory protein spx 2 HAMAP MF_01132		PRO_0000162548
Amino acid modifications
	Disulfide bond	10 ↔ 13		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q81AZ5-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 16CBE581C0BD90FF	FASTA	131	15,347
	10 20 30 40 50 60 MVILYTTASC ASCRKAKAWL EEHQIDYIEK NIVSNSMTVD ELKSILRLTE EGATEIISTR 70 80 90 100 110 120 SKTFQDLNIN IDELSLNEFY TLIIEHPLML RRPIMLDEKR LQIGFNEEEI RKFLPRSVRT 130 FLNIELQKLA N

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016877 Genomic DNA. Translation: AAP10338.1.
RefSeq	NP_833137.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1205747.
GenomeReviews	Gene locus BC_3402 in contig AE016877_GR.
KEGG	bce:BC3402.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q81AZ5.
OMA	Q81AZ5. QIGFNEE.
Enzyme and pathway databases
BioCyc	BCER226900:BC_3402-MON.
Family and domain databases
HAMAP	MF_01132. [Tree]
InterPro	IPR006660. Arsenate_reductase-like. IPR006504. CHP1617_ArsC_rel. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01617. arsC_related. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPX2_BACCR

Accession

Primary (citable) accession number: Q81AZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)