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Q819V8 (RNC_BACCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:BC_3847
OrganismBacillus cereus (strain ATCC 14579 / DSM 31) [Reference proteome] [HAMAP]
Taxonomic identifier226900 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000180373

Regions

Domain19 – 148130RNase III
Domain174 – 24370DRBM

Sites

Active site651 Potential
Active site1371 By similarity
Metal binding611Magnesium By similarity
Metal binding1341Magnesium By similarity
Metal binding1371Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q819V8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 5667F6DB726C8FFF

FASTA24528,037
        10         20         30         40         50         60 
MPYRKYREKK YETKYREAFK VFQEKIGITF TDEKLLIQAF THSSYVNEHR KKPHEDNERL 

        70         80         90        100        110        120 
EFLGDAVLEL TVSQYLFQKY PTMSEGELTK LRAAIVCEPS LVRFANELSF GSLVLLGKGE 

       130        140        150        160        170        180 
EMTGGRERPA LLADVFEAFI GALYLDQGLE TVWEFLKEIV YPKINEGAFS HVMDYKSQLQ 

       190        200        210        220        230        240 
ELIQRDGSGN VEYQILQEKG PAHNREFVSR VTLNNVALGL GSGKSKKEAE QQAAAEALKK 


LKEQL 

« Hide

References

[1]"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis."
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. expand/collapse author list , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
Nature 423:87-91(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14579 / DSM 31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016877 Genomic DNA. Translation: AAP10769.1.
RefSeqNP_833568.1. NC_004722.1.

3D structure databases

ProteinModelPortalQ819V8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226900.BC3847.

Proteomic databases

PRIDEQ819V8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP10769; AAP10769; BC_3847.
GeneID1206192.
KEGGbce:BC3847.
PATRIC32603725. VBIBacCer54481_3966.

Phylogenomic databases

eggNOGCOG0571.
KOK03685.
OMAYGFQEAR.
OrthoDBEOG6T1WVS.

Enzyme and pathway databases

BioCycBCER226900:GJEU-3843-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_BACCR
AccessionPrimary (citable) accession number: Q819V8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families