Reviewed, UniProtKB/Swiss-Prot Q819T6 (KGUA_BACCR)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	BC_3869

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Guanylate kinase HAMAP MF_00328		PRO_0000170492
Regions
	Domain	6 – 185	180	Guanylate kinase-like
	Nucleotide binding	13 – 20	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q819T6-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1AB06B54D5A4946D	FASTA	205	23,749
	10 20 30 40 50 60 MRSRRGLLIV LSRPSGVGKG TVRKELFSHE DTRFQYSISV TTRKPREGEV DGVDYFFKER 70 80 90 100 110 120 EEFEEMIRNE KLLEWAEFVG NYYGTPIDYV EKTLQEGKDV FLEIEVQGAI QVKKAFPEGV 130 140 150 160 170 180 FIFLAPPSLS ELKSRIVGRG TETEDVIENR LTVAKEEIEM MDAYDYVVEN DQVELACDRI 190 200 KAIVVGEHCR RERVAKYYKE MTEGL

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016877 Genomic DNA. Translation: AAP10791.1.
RefSeq	NP_833590.1.
3D structure databases
HSSP	HSSP built from PDB template 1GKY based on UniProtKB P15454.
ModBase	Search...
Protein-protein interaction databases
STRING	Q819T6.
Genome annotation databases
GeneID	1206214.
GenomeReviews	Gene locus BC_3869 in contig AE016877_GR.
KEGG	bce:BC3869.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q819T6.
OMA	EWAEFAG.
Enzyme and pathway databases
BioCyc	BCER226900:BC_3869-MON.
Family and domain databases
HAMAP	MF_00328. Divergent sequence. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BACCR

Accession

Primary (citable) accession number: Q819T6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)