Reviewed, UniProtKB/Swiss-Prot Q819S0 (PYRB_BACCR)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BC_3889

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Aspartate carbamoyltransferase		PRO_0000113092

Sequences

	Sequence		Length	Mass (Da)
	Q819S0-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: EA32BE78E1EA9CC8	FASTA	301	34,385
	10 20 30 40 50 60 MLTMSELSEV EISEILKDAE DFANGKESKT TEQTFVANLF FENSTRTRFS FEVAEKRLGL 70 80 90 100 110 120 DVLNFSADAS SVQKGETLYD TIRTLESIGT KAVVIRHEQD RYFDELKDQV NIPILNAGDG 130 140 150 160 170 180 CGNHPTQCLL DLLTIKQEFG RFEGLKIAIV GDVRHSRVAR SNAEALTKLG ATIYFASPEE 190 200 210 220 230 240 WKDEDNTFGT YKPLDELVPE VDVMMLLRVQ HERHDHYETD IMKEYHEKHG LTVEREKRMK 250 260 270 280 290 300 EGSIIMHPAP VNRDVEIASE LVECERSRIF KQMENGVYVR MAVLKRALPN VLGGMKHELF V

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016877 Genomic DNA. Translation: AAP10810.1.
RefSeq	NP_833609.1.
3D structure databases
HSSP	HSSP built from PDB template 1ML4 based on UniProtKB P77918.
ModBase	Search...
Genome annotation databases
GeneID	1206234.
GenomeReviews	Gene locus BC_3889 in contig AE016877_GR.
KEGG	bce:BC3889.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q819S0.
Enzyme and pathway databases
BioCyc	BCER226900:BC_3889-MON.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BACCR

Accession

Primary (citable) accession number: Q819S0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	June 1, 2003
Last modified:	November 25, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)