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Q819Q1 (MRAY_BACCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase

EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BC_3913
OrganismBacillus cereus (strain ATCC 14579 / DSM 31) [Reference proteome] [HAMAP]
Taxonomic identifier226900 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP-Rule MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP-Rule MF_00038
PRO_0000108776

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane253 – 27321Helical; Potential
Transmembrane302 – 32221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q819Q1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 2F1B78105FC3855C

FASTA32434,904
        10         20         30         40         50         60 
MLEQGLLVTA GVAFLISVAL SPLFIPFLRK LKFGQSIRDE GPKSHQKKSG TPTMGGIVIY 

        70         80         90        100        110        120 
VSMMVTSLIM AIKFNYLGAE VSLLLLVTFG YGLIGFLDDY IKVVKKRNLG LTSKQKLVGQ 

       130        140        150        160        170        180 
LVIAIAFFLI GKGQAFHTYI MIPGTDVKFE LGWAYFVLVL FMLIGGSNAV NLTDGLDGLL 

       190        200        210        220        230        240 
SGTAAIAFGA FSIIAVAQEQ FGVAIFCMAV VGAVLGFLVF NANPAKVFMG DTGSLALGGA 

       250        260        270        280        290        300 
IAAVAILLKQ ELLLVIIGGV FVMETLSVII QVISFKTTGK RVFKMSPLHH HYELCGWSEW 

       310        320 
RVVVTFWSAG FLLAVLGIYI GVWM 

« Hide

References

[1]"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis."
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. expand/collapse author list , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
Nature 423:87-91(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14579 / DSM 31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016877 Genomic DNA. Translation: AAP10834.1.
RefSeqNP_833633.1. NC_004722.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226900.BC3913.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP10834; AAP10834; BC_3913.
GeneID1206258.
KEGGbce:BC3913.
PATRIC32603863. VBIBacCer54481_4035.

Phylogenomic databases

eggNOGCOG0472.
KOK01000.
OMAHQNKKDT.
OrthoDBEOG69GZPZ.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBCER226900:GJEU-3909-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00038. MraY.
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. PTHR22926. 1 hit.
PTHR22926:SF3. PTHR22926:SF3. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BACCR
AccessionPrimary (citable) accession number: Q819Q1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways