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Q819Q1

- MRAY_BACCR

UniProt

Q819Q1 - MRAY_BACCR

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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene
mraY, BC_3913
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBCER226900:GJEU-3909-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Ordered Locus Names:BC_3913
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed predictionAdd
BLAST
Transmembranei52 – 7221Helical; Reviewed predictionAdd
BLAST
Transmembranei77 – 9721Helical; Reviewed predictionAdd
BLAST
Transmembranei122 – 14221Helical; Reviewed predictionAdd
BLAST
Transmembranei149 – 16921Helical; Reviewed predictionAdd
BLAST
Transmembranei176 – 19621Helical; Reviewed predictionAdd
BLAST
Transmembranei201 – 22121Helical; Reviewed predictionAdd
BLAST
Transmembranei227 – 24721Helical; Reviewed predictionAdd
BLAST
Transmembranei253 – 27321Helical; Reviewed predictionAdd
BLAST
Transmembranei302 – 32221Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotationPRO_0000108776Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226900.BC3913.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0472.
KOiK01000.
OMAiVVAYGTY.
OrthoDBiEOG69GZPZ.

Family and domain databases

HAMAPiMF_00038. MraY.
InterProiIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiPS01348. MRAY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q819Q1-1 [UniParc]FASTAAdd to Basket

« Hide

MLEQGLLVTA GVAFLISVAL SPLFIPFLRK LKFGQSIRDE GPKSHQKKSG    50
TPTMGGIVIY VSMMVTSLIM AIKFNYLGAE VSLLLLVTFG YGLIGFLDDY 100
IKVVKKRNLG LTSKQKLVGQ LVIAIAFFLI GKGQAFHTYI MIPGTDVKFE 150
LGWAYFVLVL FMLIGGSNAV NLTDGLDGLL SGTAAIAFGA FSIIAVAQEQ 200
FGVAIFCMAV VGAVLGFLVF NANPAKVFMG DTGSLALGGA IAAVAILLKQ 250
ELLLVIIGGV FVMETLSVII QVISFKTTGK RVFKMSPLHH HYELCGWSEW 300
RVVVTFWSAG FLLAVLGIYI GVWM 324
Length:324
Mass (Da):34,904
Last modified:June 1, 2003 - v1
Checksum:i2F1B78105FC3855C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP10834.1.
RefSeqiNP_833633.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP10834; AAP10834; BC_3913.
GeneIDi1206258.
KEGGibce:BC3913.
PATRICi32603863. VBIBacCer54481_4035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP10834.1 .
RefSeqi NP_833633.1. NC_004722.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226900.BC3913.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP10834 ; AAP10834 ; BC_3913 .
GeneIDi 1206258.
KEGGi bce:BC3913.
PATRICi 32603863. VBIBacCer54481_4035.

Phylogenomic databases

eggNOGi COG0472.
KOi K01000.
OMAi VVAYGTY.
OrthoDBi EOG69GZPZ.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BCER226900:GJEU-3909-MONOMER.

Family and domain databases

HAMAPi MF_00038. MraY.
InterProi IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view ]
PANTHERi PTHR22926. PTHR22926. 1 hit.
Pfami PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00445. mraY. 1 hit.
PROSITEi PS01348. MRAY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31.

Entry informationi

Entry nameiMRAY_BACCR
AccessioniPrimary (citable) accession number: Q819Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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