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Q819Q1

- MRAY_BACCR

UniProt

Q819Q1 - MRAY_BACCR

Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

    Catalytic activityi

    UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-HAMAP
    2. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBCER226900:GJEU-3909-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
    Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
    Gene namesi
    Name:mraYUniRule annotation
    Ordered Locus Names:BC_3913
    OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
    Taxonomic identifieri226900 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000001417: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Phospho-N-acetylmuramoyl-pentapeptide-transferasePRO_0000108776Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi226900.BC3913.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalUniRule annotationAdd
    BLAST
    Transmembranei52 – 7221HelicalUniRule annotationAdd
    BLAST
    Transmembranei77 – 9721HelicalUniRule annotationAdd
    BLAST
    Transmembranei122 – 14221HelicalUniRule annotationAdd
    BLAST
    Transmembranei149 – 16921HelicalUniRule annotationAdd
    BLAST
    Transmembranei176 – 19621HelicalUniRule annotationAdd
    BLAST
    Transmembranei201 – 22121HelicalUniRule annotationAdd
    BLAST
    Transmembranei227 – 24721HelicalUniRule annotationAdd
    BLAST
    Transmembranei253 – 27321HelicalUniRule annotationAdd
    BLAST
    Transmembranei302 – 32221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0472.
    KOiK01000.
    OMAiVVAYGTY.
    OrthoDBiEOG69GZPZ.

    Family and domain databases

    HAMAPiMF_00038. MraY.
    InterProiIPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view]
    PANTHERiPTHR22926. PTHR22926. 1 hit.
    PfamiPF00953. Glycos_transf_4. 1 hit.
    PF10555. MraY_sig1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00445. mraY. 1 hit.
    PROSITEiPS01348. MRAY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q819Q1-1 [UniParc]FASTAAdd to Basket

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    MLEQGLLVTA GVAFLISVAL SPLFIPFLRK LKFGQSIRDE GPKSHQKKSG    50
    TPTMGGIVIY VSMMVTSLIM AIKFNYLGAE VSLLLLVTFG YGLIGFLDDY 100
    IKVVKKRNLG LTSKQKLVGQ LVIAIAFFLI GKGQAFHTYI MIPGTDVKFE 150
    LGWAYFVLVL FMLIGGSNAV NLTDGLDGLL SGTAAIAFGA FSIIAVAQEQ 200
    FGVAIFCMAV VGAVLGFLVF NANPAKVFMG DTGSLALGGA IAAVAILLKQ 250
    ELLLVIIGGV FVMETLSVII QVISFKTTGK RVFKMSPLHH HYELCGWSEW 300
    RVVVTFWSAG FLLAVLGIYI GVWM 324
    Length:324
    Mass (Da):34,904
    Last modified:June 1, 2003 - v1
    Checksum:i2F1B78105FC3855C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016877 Genomic DNA. Translation: AAP10834.1.
    RefSeqiNP_833633.1. NC_004722.1.

    Genome annotation databases

    EnsemblBacteriaiAAP10834; AAP10834; BC_3913.
    GeneIDi1206258.
    KEGGibce:BC3913.
    PATRICi32603863. VBIBacCer54481_4035.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016877 Genomic DNA. Translation: AAP10834.1 .
    RefSeqi NP_833633.1. NC_004722.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226900.BC3913.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP10834 ; AAP10834 ; BC_3913 .
    GeneIDi 1206258.
    KEGGi bce:BC3913.
    PATRICi 32603863. VBIBacCer54481_4035.

    Phylogenomic databases

    eggNOGi COG0472.
    KOi K01000.
    OMAi VVAYGTY.
    OrthoDBi EOG69GZPZ.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci BCER226900:GJEU-3909-MONOMER.

    Family and domain databases

    HAMAPi MF_00038. MraY.
    InterProi IPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view ]
    PANTHERi PTHR22926. PTHR22926. 1 hit.
    Pfami PF00953. Glycos_transf_4. 1 hit.
    PF10555. MraY_sig1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00445. mraY. 1 hit.
    PROSITEi PS01348. MRAY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14579 / DSM 31.

    Entry informationi

    Entry nameiMRAY_BACCR
    AccessioniPrimary (citable) accession number: Q819Q1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3