Q819L4 (SPEA_BACCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine decarboxylase
EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	BC_3962

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31)

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of agmatine from arginine By similarity.
Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-I family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Putrescine biosynthesis Spermidine biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Arginine decarboxylase		PRO_0000201145
Amino acid modifications
	Modified residue	226	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q819L4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 92EB8987F823C839	FASTA	460	50,324
	10 20 30 40 50 60 MSQYETPLFT ALVEHSKRNP IQFHIPGHKK GQGMDPTFRE FIGHNALAID LINIAPLDDL 70 80 90 100 110 120 HHPKGMIKEA QDLAAAAFGA DHTFFSIQGT SGAIMTMVMS VCGPGDKILV PRNVHKSVMS 130 140 150 160 170 180 AIIFSGAKPI FMHPEIDPKL GISHGITIQS VKKALEEHSD AKGLLVINPT YFGFAADLEQ 190 200 210 220 230 240 IVQLAHSYDI PVLVDEAHGV HIHFHDELPM SAMQAGADMA ATSVHKLGGS LTQSSILNVK 250 260 270 280 290 300 EGLVNVKHVQ SIISMLTTTS TSYILLASLD VARKRLATEG TALIEQTIQL AEHVRDAINS 310 320 330 340 350 360 IEHLYCPGKE MLGTDATFNY DPTKIIVSVK DLGITGHQAE VWLREQYNIE VELSDLYNIL 370 380 390 400 410 420 CLITLGDTES DTNTLIAALQ DLAATFRNRA DKGVQVQVEI PEIPVLALSP RDAFYSETEV 430 440 450 460 IPFENAAGRI IADFVMVYPP GIPIFTPGGN YYTRKLRVYS

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 14579 / DSM 31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016877 Genomic DNA. Translation: AAP10882.1.
RefSeq	NP_833681.1. NC_004722.1.
3D structure databases
ProteinModelPortal	Q819L4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q819L4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000031689; EBBACP00000030895; EBBACG00000031680.
GeneID	1206307.
GenomeReviews	Gene locus BC_3962 in contig AE016877_GR.
KEGG	bce:BC3962.
PATRIC	32603966. VBIBacCer54481_4086.
Phylogenomic databases
eggNOG	COG1982.
GeneTree	EBGT00050000002042.
HOGENOM	HBG634412.
OMA	MEYVNRK.
ProtClustDB	CLSK873379.
Enzyme and pathway databases
BioCyc	BCER226900:BC_3962-MONOMER.
Family and domain databases
InterPro	IPR000310. Orn/Lys/Arg_deCO2ase_major_dom. IPR008286. Prn/Lys/Arg_de-COase_C. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.90.100.10. Decarbxylse_C. 1 hit. G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KO	K01585.
Pfam	PF01276. OKR_DC_1. 1 hit. PF03711. OKR_DC_1_C. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00703. OKR_DC_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_BACCR

Accession

Primary (citable) accession number: Q819L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program