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Protein

Arginine decarboxylase

Gene

speA

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of agmatine from arginine.By similarity

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Pathway:iagmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBCER226900:GJEU-3958-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase (EC:4.1.1.19)
Gene namesi
Name:speA
Ordered Locus Names:BC_3962
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Arginine decarboxylasePRO_0000201145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ819L4.

Interactioni

Protein-protein interaction databases

STRINGi226900.BC3962.

Structurei

3D structure databases

ProteinModelPortaliQ819L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1982.
KOiK01585.
OMAiYSAMEAG.
OrthoDBiEOG61CKX5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q819L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQYETPLFT ALVEHSKRNP IQFHIPGHKK GQGMDPTFRE FIGHNALAID
60 70 80 90 100
LINIAPLDDL HHPKGMIKEA QDLAAAAFGA DHTFFSIQGT SGAIMTMVMS
110 120 130 140 150
VCGPGDKILV PRNVHKSVMS AIIFSGAKPI FMHPEIDPKL GISHGITIQS
160 170 180 190 200
VKKALEEHSD AKGLLVINPT YFGFAADLEQ IVQLAHSYDI PVLVDEAHGV
210 220 230 240 250
HIHFHDELPM SAMQAGADMA ATSVHKLGGS LTQSSILNVK EGLVNVKHVQ
260 270 280 290 300
SIISMLTTTS TSYILLASLD VARKRLATEG TALIEQTIQL AEHVRDAINS
310 320 330 340 350
IEHLYCPGKE MLGTDATFNY DPTKIIVSVK DLGITGHQAE VWLREQYNIE
360 370 380 390 400
VELSDLYNIL CLITLGDTES DTNTLIAALQ DLAATFRNRA DKGVQVQVEI
410 420 430 440 450
PEIPVLALSP RDAFYSETEV IPFENAAGRI IADFVMVYPP GIPIFTPGGN
460
YYTRKLRVYS
Length:460
Mass (Da):50,324
Last modified:June 1, 2003 - v1
Checksum:i92EB8987F823C839
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP10882.1.
RefSeqiNP_833681.1. NC_004722.1.
WP_011110347.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP10882; AAP10882; BC_3962.
GeneIDi1206307.
KEGGibce:BC3962.
PATRICi32603966. VBIBacCer54481_4086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP10882.1.
RefSeqiNP_833681.1. NC_004722.1.
WP_011110347.1. NC_004722.1.

3D structure databases

ProteinModelPortaliQ819L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226900.BC3962.

Proteomic databases

PRIDEiQ819L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP10882; AAP10882; BC_3962.
GeneIDi1206307.
KEGGibce:BC3962.
PATRICi32603966. VBIBacCer54481_4086.

Phylogenomic databases

eggNOGiCOG1982.
KOiK01585.
OMAiYSAMEAG.
OrthoDBiEOG61CKX5.

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.
BioCyciBCER226900:GJEU-3958-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711.

Entry informationi

Entry nameiSPEA_BACCR
AccessioniPrimary (citable) accession number: Q819L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.