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Protein

Arginine decarboxylase

Gene

speA

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of agmatine from arginine.By similarity

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase (EC:4.1.1.19)
Gene namesi
Name:speA
Ordered Locus Names:BC_3962
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011451 – 460Arginine decarboxylaseAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Protein-protein interaction databases

STRINGi226900.BC3962

Structurei

3D structure databases

ProteinModelPortaliQ819L4
SMRiQ819L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN Bacteria
COG1982 LUCA
KOiK01585
OMAiWSTLLTE

Family and domain databases

CDDicd00615 Orn_deC_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR000310 Orn/Lys/Arg_deCO2ase_major_dom
IPR008286 Prn/Lys/Arg_de-COase_C
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF01276 OKR_DC_1, 1 hit
PF03711 OKR_DC_1_C, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00703 OKR_DC_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q819L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQYETPLFT ALVEHSKRNP IQFHIPGHKK GQGMDPTFRE FIGHNALAID
60 70 80 90 100
LINIAPLDDL HHPKGMIKEA QDLAAAAFGA DHTFFSIQGT SGAIMTMVMS
110 120 130 140 150
VCGPGDKILV PRNVHKSVMS AIIFSGAKPI FMHPEIDPKL GISHGITIQS
160 170 180 190 200
VKKALEEHSD AKGLLVINPT YFGFAADLEQ IVQLAHSYDI PVLVDEAHGV
210 220 230 240 250
HIHFHDELPM SAMQAGADMA ATSVHKLGGS LTQSSILNVK EGLVNVKHVQ
260 270 280 290 300
SIISMLTTTS TSYILLASLD VARKRLATEG TALIEQTIQL AEHVRDAINS
310 320 330 340 350
IEHLYCPGKE MLGTDATFNY DPTKIIVSVK DLGITGHQAE VWLREQYNIE
360 370 380 390 400
VELSDLYNIL CLITLGDTES DTNTLIAALQ DLAATFRNRA DKGVQVQVEI
410 420 430 440 450
PEIPVLALSP RDAFYSETEV IPFENAAGRI IADFVMVYPP GIPIFTPGGN
460
YYTRKLRVYS
Length:460
Mass (Da):50,324
Last modified:June 1, 2003 - v1
Checksum:i92EB8987F823C839
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA Translation: AAP10882.1
RefSeqiNP_833681.1, NC_004722.1
WP_011110347.1, NC_004722.1

Genome annotation databases

EnsemblBacteriaiAAP10882; AAP10882; BC_3962
GeneIDi1206307
KEGGibce:BC3962
PATRICifig|226900.8.peg.4086

Similar proteinsi

Entry informationi

Entry nameiSPEA_BACCR
AccessioniPrimary (citable) accession number: Q819L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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