Q818M3 (GCST_BACCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	BC_4226

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31)

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Aminomethyltransferase HAMAP MF_00259		PRO_0000122537

Sequences

	Sequence		Length	Mass (Da)
	Q818M3 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B20A4A96ACF8D4BA	FASTA	366	40,225
	10 20 30 40 50 60 MITLQRTPLF DVYAKYGGKT IDFGGWELPV QFSSIKEEHE AVRTAAGLFD VSHMGEVEVK 70 80 90 100 110 120 GVDSLAFLQR VVTNDVSTLK VGGAQYTAMC YENGGTVDDL LIYKRGEEDY LLVINASNIE 130 140 150 160 170 180 KDYEWLASHV IGDATVVNVS SEVAQLAIQG PKAEGILQKV VSEDLKEIKF FKFKNDILVD 190 200 210 220 230 240 GIPALVSRTG YTGEDGFEIY CKSEDAAKLW EKLLEVGAEE GLKACGLGAR DTLRFEATLP 250 260 270 280 290 300 LYGQELSKDI TPIEAGIGFA VKTNKEADFF GKATLKEQKE NGAPRKLVGI EVIERGIPRT 310 320 330 340 350 360 HYPVFIGEEK IGEVTSGTQS PTLKKSIGLA LIDVKYAAVD TEVEIEIRNK RVKAVVVPTP FYKRSK

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 14579 / DSM 31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016877 Genomic DNA. Translation: AAP11141.1.
RefSeq	NP_833940.1. NC_004722.1.
3D structure databases
ProteinModelPortal	Q818M3.
SMR	Q818M3. Positions 4-364.
ModBase	Search...
Protein-protein interaction databases
STRING	Q818M3.
Proteomic databases
PRIDE	Q818M3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000034357; EBBACP00000033563; EBBACG00000034348.
GeneID	1206571.
GenomeReviews	Gene locus BC_4226 in contig AE016877_GR.
KEGG	bce:BC4226.
PATRIC	32604528. VBIBacCer54481_4367.
Phylogenomic databases
eggNOG	COG0404.
GeneTree	EBGT00050000001932.
HOGENOM	HBG299834.
OMA	VINASNK.
PhylomeDB	Q818M3.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	BCER226900:BC_4226-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BACCR

Accession

Primary (citable) accession number: Q818M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program