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Q817C7 (ARLY_BACCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:BC_4629
OrganismBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifier226900 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Argininosuccinate lyase HAMAP MF_00006
PRO_0000137736

Sequences

Sequence LengthMass (Da)Tools
Q817C7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 89B40F375B9CA610

FASTA46252,268
        10         20         30         40         50         60 
MSKLWGGRFT EEAEAWVEEF GASISFDQQL VNQDINGSMA HVTMLAKQGI VTQEEAEKIK 

        70         80         90        100        110        120 
IGLQYLLKEA KENKLQFSVE AEDIHLNIEK MLIEQIGEVG GKLHTGRSRN DQVATDMHLY 

       130        140        150        160        170        180 
LKEKVEHIIK ATKQLQTVLV QQAENNIETI MPGYTHLQRA QPISFAHHIL AYFWMLERDV 

       190        200        210        220        230        240 
NRYEDSLKRI NISPLGAGAL AGTTFPIDRE YSAELLGFNG IYENSLDAVS DRDFILEFLS 

       250        260        270        280        290        300 
NSSMLMMHLS RFCEELILWS SQEFQFIEMS DQYATGSSIM PQKKNPDMAE LIRGKTGRVY 

       310        320        330        340        350        360 
GNLFSLLTVM KGLPLAYNKD LQEDKEGMFD TVKTVEGCLH IMTGMLETMT VNKEKMGQAV 

       370        380        390        400        410        420 
TQDFSNATEI ADYLANKGLP FRQAHEIVGK LVLYCTQKGI YLLDVSLETY KEMSSLFEED 

       430        440        450        460 
LYEVLSPYAA VKRRNSAGGT GFEQIKNALE KAKGLTKEVI KN

« Hide

References

[1]"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis."
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. expand/collapse author list , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
Nature 423:87-91(2003) [PubMed: 12721630] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14579 / DSM 31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016877 Genomic DNA. Translation: AAP11536.1.
RefSeqNP_834335.1. NC_004722.1.

3D structure databases

ProteinModelPortalQ817C7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ817C7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000033136; EBBACP00000032342; EBBACG00000033127.
GeneID1206974.
GenomeReviewsGene locus BC_4629 in contig AE016877_GR.
KEGGbce:BC4629.
PATRIC32605387. VBIBacCer54481_4792.

Phylogenomic databases

eggNOGCOG0165.
GeneTreeEBGT00070000031828.
HOGENOMHBG539632.
OMAEDIHTVI.
PhylomeDBQ817C7.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycBCER226900:BC_4629-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_BACCR
AccessionPrimary (citable) accession number: Q817C7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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