Reviewed, UniProtKB/Swiss-Prot Q817C7 (ARLY_BACCR)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BC_4629

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137736

Sequences

	Sequence		Length	Mass (Da)
	Q817C7-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 89B40F375B9CA610	FASTA	462	52,268
	10 20 30 40 50 60 MSKLWGGRFT EEAEAWVEEF GASISFDQQL VNQDINGSMA HVTMLAKQGI VTQEEAEKIK 70 80 90 100 110 120 IGLQYLLKEA KENKLQFSVE AEDIHLNIEK MLIEQIGEVG GKLHTGRSRN DQVATDMHLY 130 140 150 160 170 180 LKEKVEHIIK ATKQLQTVLV QQAENNIETI MPGYTHLQRA QPISFAHHIL AYFWMLERDV 190 200 210 220 230 240 NRYEDSLKRI NISPLGAGAL AGTTFPIDRE YSAELLGFNG IYENSLDAVS DRDFILEFLS 250 260 270 280 290 300 NSSMLMMHLS RFCEELILWS SQEFQFIEMS DQYATGSSIM PQKKNPDMAE LIRGKTGRVY 310 320 330 340 350 360 GNLFSLLTVM KGLPLAYNKD LQEDKEGMFD TVKTVEGCLH IMTGMLETMT VNKEKMGQAV 370 380 390 400 410 420 TQDFSNATEI ADYLANKGLP FRQAHEIVGK LVLYCTQKGI YLLDVSLETY KEMSSLFEED 430 440 450 460 LYEVLSPYAA VKRRNSAGGT GFEQIKNALE KAKGLTKEVI KN

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016877 Genomic DNA. Translation: AAP11536.1.
RefSeq	NP_834335.1.
3D structure databases
SMR	Q817C7. Positions 14-454.
ModBase	Search...
Protein-protein interaction databases
STRING	Q817C7.
Genome annotation databases
GeneID	1206974.
GenomeReviews	Gene locus BC_4629 in contig AE016877_GR.
KEGG	bce:BC4629.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	ATDTRLY.
Enzyme and pathway databases
BioCyc	BCER226900:BC_4629-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BACCR

Accession

Primary (citable) accession number: Q817C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)