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Q817B5

- NADK2_BACCR

UniProt

Q817B5 - NADK2_BACCR

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Protein

NAD kinase 2

Gene
nadK2, BC_4642
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Proton acceptor By similarity
Binding sitei151 – 1511NAD By similarity
Binding sitei153 – 1531NAD By similarity
Binding sitei188 – 1881NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi52 – 532NAD By similarity
Nucleotide bindingi124 – 1252NAD By similarity
Nucleotide bindingi164 – 1696NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCER226900:GJEU-4638-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 2
Gene namesi
Name:nadK2
Ordered Locus Names:BC_4642
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267NAD kinase 2UniRule annotationPRO_0000120594Add
BLAST

Proteomic databases

PRIDEiQ817B5.

Interactioni

Protein-protein interaction databases

STRINGi226900.BC4642.

Structurei

3D structure databases

ProteinModelPortaliQ817B5.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiDDLHFET.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q817B5-1 [UniParc]FASTAAdd to Basket

« Hide

MADRRNLFFF YGDDKATLVE KMKPIYRILE ENGFTILDHP KNANAIVSVG    50
DDATFLQAVR KTGFREDCLY AGISTKDEIS FYCDFHIDHV DTALQEITKN 100
EIEVRKYPTI QVDVDGSTSF HCLNEFSLRS SIIKTFVVDV HVDDLYFETF 150
RGDGLVVSTP TGSTAYNKSL HGAVVDPLIP CFQVSELASL NNNTYRTLGS 200
PFILNHERTL TLKLRPDGND YPVIGMDNEA LSIKQVEKAV VRLSDKQIKT 250
VKLKNNSFWE KVQRTFL 267
Length:267
Mass (Da):30,317
Last modified:June 1, 2003 - v1
Checksum:i47ABF8120C71E164
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP11549.1.
RefSeqiNP_834348.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP11549; AAP11549; BC_4642.
GeneIDi1206987.
KEGGibce:BC4642.
PATRICi32605415. VBIBacCer54481_4806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP11549.1 .
RefSeqi NP_834348.1. NC_004722.1.

3D structure databases

ProteinModelPortali Q817B5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226900.BC4642.

Proteomic databases

PRIDEi Q817B5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP11549 ; AAP11549 ; BC_4642 .
GeneIDi 1206987.
KEGGi bce:BC4642.
PATRICi 32605415. VBIBacCer54481_4806.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi DDLHFET.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci BCER226900:GJEU-4638-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31.

Entry informationi

Entry nameiNADK2_BACCR
AccessioniPrimary (citable) accession number: Q817B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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