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Q817B5

- NADK2_BACCR

UniProt

Q817B5 - NADK2_BACCR

Protein

NAD kinase 2

Gene

nadK2

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521Proton acceptorUniRule annotation
    Binding sitei151 – 1511NADUniRule annotation
    Binding sitei153 – 1531NADUniRule annotation
    Binding sitei188 – 1881NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi52 – 532NADUniRule annotation
    Nucleotide bindingi124 – 1252NADUniRule annotation
    Nucleotide bindingi164 – 1696NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCER226900:GJEU-4638-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 2UniRule annotation
    Gene namesi
    Name:nadK2UniRule annotation
    Ordered Locus Names:BC_4642
    OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
    Taxonomic identifieri226900 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000001417: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267NAD kinase 2PRO_0000120594Add
    BLAST

    Proteomic databases

    PRIDEiQ817B5.

    Interactioni

    Protein-protein interaction databases

    STRINGi226900.BC4642.

    Structurei

    3D structure databases

    ProteinModelPortaliQ817B5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiDDLHFET.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q817B5-1 [UniParc]FASTAAdd to Basket

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    MADRRNLFFF YGDDKATLVE KMKPIYRILE ENGFTILDHP KNANAIVSVG    50
    DDATFLQAVR KTGFREDCLY AGISTKDEIS FYCDFHIDHV DTALQEITKN 100
    EIEVRKYPTI QVDVDGSTSF HCLNEFSLRS SIIKTFVVDV HVDDLYFETF 150
    RGDGLVVSTP TGSTAYNKSL HGAVVDPLIP CFQVSELASL NNNTYRTLGS 200
    PFILNHERTL TLKLRPDGND YPVIGMDNEA LSIKQVEKAV VRLSDKQIKT 250
    VKLKNNSFWE KVQRTFL 267
    Length:267
    Mass (Da):30,317
    Last modified:June 1, 2003 - v1
    Checksum:i47ABF8120C71E164
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016877 Genomic DNA. Translation: AAP11549.1.
    RefSeqiNP_834348.1. NC_004722.1.

    Genome annotation databases

    EnsemblBacteriaiAAP11549; AAP11549; BC_4642.
    GeneIDi1206987.
    KEGGibce:BC4642.
    PATRICi32605415. VBIBacCer54481_4806.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016877 Genomic DNA. Translation: AAP11549.1 .
    RefSeqi NP_834348.1. NC_004722.1.

    3D structure databases

    ProteinModelPortali Q817B5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226900.BC4642.

    Proteomic databases

    PRIDEi Q817B5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP11549 ; AAP11549 ; BC_4642 .
    GeneIDi 1206987.
    KEGGi bce:BC4642.
    PATRICi 32605415. VBIBacCer54481_4806.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi DDLHFET.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci BCER226900:GJEU-4638-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14579 / DSM 31.

    Entry informationi

    Entry nameiNADK2_BACCR
    AccessioniPrimary (citable) accession number: Q817B5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3