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Reviewed, UniProtKB/Swiss-Prot Q815R9 (MURB2_BACCR)

Last modified February 9, 2010. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    UDP-N-acetylenolpyruvoylglucosamine reductase 2
    EC=1.1.1.158
Alternative name(s):
    UDP-N-acetylmuramate dehydrogenase 2
Gene names
Name: murB2
Ordered Locus Names: BC_5063
OrganismBacillus cereus (strain ATCC 14579 / DSM 31) [Complete proteome] [HAMAP]
Taxonomic identifier226900 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00037

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity. HAMAP MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm Probable HAMAP MF_00037.

Sequence similarities

Belongs to the murB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305UDP-N-acetylenolpyruvoylglucosamine reductase 2 HAMAP MF_00037
PRO_0000179175

Regions

Domain33 – 197165FAD-binding PCMH-type

Sites

Active site1761 By similarity
Active site2261Proton donor By similarity
Active site2961 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q815R9-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E269417D2EE5A1ED

FASTA30533,506
        10         20         30         40         50         60 
MNMQEVYKYL STVLPEGHVK QDEMLKNHTH IKVGGKADVF VAPTNYDEIQ EVIKYANEYN 

        70         80         90        100        110        120 
IPVTFLGNGS NVIIKDGGIR GITVSLIHIT GVTVTGTTIV AQCGAAIIDV SRIALDHNLT 

       130        140        150        160        170        180 
GLEFACGIPG SVGGALYMNA GAYGGEISFV LTEAVVMTGD GELRTLTKEA FEFGYRKSVF 

       190        200        210        220        230        240 
ANNHYIILEA RFELEEGVHE EIKAKMDDLT FKRESKQPLE YPSCGSVFKR PPNNFAGKLI 

       250        260        270        280        290        300 
QDSGLQGKRI GGVEVSLKHA GFMVNVDNGT AQDYIDLIHF VQKTVEEKFG VKLEREVRII 


GEDKE 

« Hide

References

[1]"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis."
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. expand/collapse author list , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
Nature 423:87-91(2003) [PubMed: 12721630] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016877 Genomic DNA. Translation: AAP11932.1.
RefSeqNP_834731.1.

3D structure databases

SMRQ815R9. Positions 4-302.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ815R9.

Genome annotation databases

GeneID1207404.
GenomeReviewsGene locus BC_5063 in contig AE016877_GR.
KEGGbce:BC5063.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0812.
HOGENOMHBG686573.
OMAQPIREKT.

Enzyme and pathway databases

BioCycBCER226900:BC_5063-MONOMER.

Family and domain databases

HAMAPMF_00037. MurB.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00179. murB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB2_BACCR
AccessionPrimary (citable) accession number: Q815R9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents