Q814Q2 (SPEB_BACCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Agmatinase
EC=3.5.3.11

Alternative name(s):
Agmatine ureohydrolase
Short name=AUH

Gene names

Name:	speB
Ordered Locus Names:	BC_5370

Organism

Bacillus cereus (strain ATCC 14579 / DSM 31)

Taxonomic identifier

226900 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of putrescine from agmatine By similarity.
Catalytic activity	Agmatine + H2O = putrescine + urea.
Cofactor	Manganese By similarity.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.
Sequence similarities	Belongs to the arginase family. Agmatinase subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Putrescine biosynthesis Spermidine biosynthesis
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	agmatinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Agmatinase		PRO_0000173726
Sites
	Metal binding	112	1	Manganese By similarity
	Metal binding	135	1	Manganese By similarity
	Metal binding	137	1	Manganese By similarity
	Metal binding	139	1	Manganese By similarity
	Metal binding	216	1	Manganese By similarity
	Metal binding	218	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q814Q2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D538E9EBDE734B5B	FASTA	290	32,389
	10 20 30 40 50 60 MRFDEAYSGK VFIKSHPSFE ESKVVIYGMP MDWTVSYRPG SRFGPARIRE VSIGLEEYSP 70 80 90 100 110 120 YLDRELEEVK YFDAGDIPLP FGNAQRSLDM IEEYVSKLLD ADKFPLGLGG EHLVSWPIFK 130 140 150 160 170 180 AMAKKYPDLA IIHMDAHTDL RESYEGEPLS HSTPIRKVCD LIGPENVYSF GIRSGMKEEF 190 200 210 220 230 240 EWAKEVGMNL YKFDVLEPLK EVLPKLAGRP VYVTIDIDVL DPAHAPGTGT LEAGGITSKE 250 260 270 280 290 LLDSIVAIAN SNINVVGADL VEVAPVYDHS DQTPVAASKF VREMLLGWVK

References

[1]

"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis." Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C. Nature 423:87-91(2003) [PubMed: 12721630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 14579 / DSM 31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016877 Genomic DNA. Translation: AAP12232.1.
RefSeq	NP_835031.1. NC_004722.1.
3D structure databases
ProteinModelPortal	Q814Q2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q814Q2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000032996; EBBACP00000032202; EBBACG00000032987.
GeneID	1207710.
GenomeReviews	Gene locus BC_5370 in contig AE016877_GR.
KEGG	bce:BC5370.
PATRIC	32606948. VBIBacCer54481_5545.
Phylogenomic databases
eggNOG	COG0010.
GeneTree	EBGT00050000001627.
HOGENOM	HBG391953.
OMA	REMLLGF.
ProtClustDB	CLSK888062.
Enzyme and pathway databases
BioCyc	BCER226900:BC_5370-MONOMER.
Family and domain databases
InterPro	IPR005925. Agmatinase-rel. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_domain. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
KO	K01480.
PANTHER	PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PIRSF	PIRSF036979. Arginase. 1 hit.
TIGRFAMs	TIGR01230. Agmatinase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEB_BACCR

Accession

Primary (citable) accession number: Q814Q2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program