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Q812T8 (MURG2_BACCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 2
Gene names
Name:murG2
Ordered Locus Names:BC_4249
OrganismBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifier226900 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2 HAMAP MF_00033
PRO_0000109141

Sequences

Sequence LengthMass (Da)Tools
Q812T8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: C2CC83A336BEA774

FASTA35239,436
        10         20         30         40         50         60 
MKKIVFTGGG SAGHVTPNLA IIPYLQEDNW DISYIGSHQG IEKTIIEKEG IPYYSISSGK 

        70         80         90        100        110        120 
LRRYFDLKNI KDPFLVMKGV MDAYVRIRKL KPDVIFSKGG FVSVPVVIGG WLNRVPVLLH 

       130        140        150        160        170        180 
ESDMTPGLAN KIALRFASKI FVTFEEAAKH LPKEKVIYTG SPVREEVLKG NREKGLAFLG 

       190        200        210        220        230        240 
FSRKKPVITI MGGSLGAKKI NETVRSALPE LLKKYQIVHL CGKGNLDESL QNKEGYRQFE 

       250        260        270        280        290        300 
YVHGELPDIL AVTDFVISRA GSNAIFEFLT LQKPMVLIPL SKFASRGDQI LNAESFERQG 

       310        320        330        340        350 
YASVLYEEDV NVKSLIKYVE ELSQNNEKYK TALKKYNGKE AIKTIIQNIS EA

« Hide

References

[1]"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis."
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G. expand/collapse author list , Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
Nature 423:87-91(2003) [PubMed: 12721630] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14579 / DSM 31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016877 Genomic DNA. Translation: AAP11164.1.
RefSeqNP_833963.1. NC_004722.1.

3D structure databases

ProteinModelPortalQ812T8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ812T8.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000031821; EBBACP00000031027; EBBACG00000031812.
GeneID1206594.
GenomeReviewsGene locus BC_4249 in contig AE016877_GR.
KEGGbce:BC4249.
PATRIC32604580. VBIBacCer54481_4393.

Phylogenomic databases

eggNOGCOG0707.
GeneTreeEBGT00050000001194.
HOGENOMHBG617076.
OMAHICGKGN.
PhylomeDBQ812T8.
ProtClustDBPRK12446.

Enzyme and pathway databases

BioCycBCER226900:BC_4249-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG2_BACCR
AccessionPrimary (citable) accession number: Q812T8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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