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Q812Q3

- HDOX_BACCR

UniProt

Q812Q3 - HDOX_BACCR

Protein

Heme-degrading monooxygenase

Gene

isdG

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61IronUniRule annotation
    Sitei66 – 661Transition state stabilizerUniRule annotation
    Metal bindingi76 – 761Iron (heme axial ligand)UniRule annotation

    GO - Molecular functioni

    1. heme binding Source: UniProtKB-HAMAP
    2. heme oxygenase (decyclizing) activity Source: UniProtKB-HAMAP
    3. iron ion binding Source: UniProtKB-HAMAP
    4. monooxygenase activity Source: UniProtKB-KW

    GO - Biological processi

    1. heme catabolic process Source: UniProtKB-HAMAP
    2. iron assimilation Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBCER226900:GJEU-4538-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme-degrading monooxygenaseUniRule annotation (EC:1.14.99.3)
    Alternative name(s):
    Heme oxygenaseUniRule annotation
    Iron-regulated surface determinantUniRule annotation
    Iron-responsive surface determinantUniRule annotation
    Gene namesi
    Name:isdGUniRule annotation
    Ordered Locus Names:BC_4542
    OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
    Taxonomic identifieri226900 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000001417: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 107107Heme-degrading monooxygenasePRO_0000270072Add
    BLAST

    Proteomic databases

    PRIDEiQ812Q3.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi226900.BC4542.

    Structurei

    3D structure databases

    ProteinModelPortaliQ812Q3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 9493ABMAdd
    BLAST

    Sequence similaritiesi

    Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation
    Contains 1 ABM domain.Curated

    Phylogenomic databases

    eggNOGiCOG2329.
    KOiK07145.
    OMAiFRESHSH.
    OrthoDBiEOG6GTZMS.

    Family and domain databases

    HAMAPiMF_01272. Heme_degrading_monooxygenase.
    InterProiIPR007138. ABM-like.
    IPR011008. Dimeric_a/b-barrel.
    IPR023953. IsdG.
    [Graphical view]
    PfamiPF03992. ABM. 1 hit.
    [Graphical view]
    SUPFAMiSSF54909. SSF54909. 1 hit.
    PROSITEiPS51725. ABM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q812Q3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIVTNTAKI TKGNGHKLIE RFNKVGKVET MPGFLGLEVL LTQNTVDYDE    50
    VTISTRWNAK EDFQGWTKSA AFKDAHSHQG GMPEYILDNK IAYYDVKVVR 100
    MPMAAAQ 107
    Length:107
    Mass (Da):12,034
    Last modified:June 1, 2003 - v1
    Checksum:iE98EA5B28C19575C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016877 Genomic DNA. Translation: AAP11450.1.
    RefSeqiNP_834249.1. NC_004722.1.

    Genome annotation databases

    EnsemblBacteriaiAAP11450; AAP11450; BC_4542.
    GeneIDi1206887.
    KEGGibce:BC4542.
    PATRICi32605203. VBIBacCer54481_4700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016877 Genomic DNA. Translation: AAP11450.1 .
    RefSeqi NP_834249.1. NC_004722.1.

    3D structure databases

    ProteinModelPortali Q812Q3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226900.BC4542.

    Proteomic databases

    PRIDEi Q812Q3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP11450 ; AAP11450 ; BC_4542 .
    GeneIDi 1206887.
    KEGGi bce:BC4542.
    PATRICi 32605203. VBIBacCer54481_4700.

    Phylogenomic databases

    eggNOGi COG2329.
    KOi K07145.
    OMAi FRESHSH.
    OrthoDBi EOG6GTZMS.

    Enzyme and pathway databases

    BioCyci BCER226900:GJEU-4538-MONOMER.

    Family and domain databases

    HAMAPi MF_01272. Heme_degrading_monooxygenase.
    InterProi IPR007138. ABM-like.
    IPR011008. Dimeric_a/b-barrel.
    IPR023953. IsdG.
    [Graphical view ]
    Pfami PF03992. ABM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54909. SSF54909. 1 hit.
    PROSITEi PS51725. ABM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14579 / DSM 31.

    Entry informationi

    Entry nameiHDOX_BACCR
    AccessioniPrimary (citable) accession number: Q812Q3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3