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Q812Q3

- HDOX_BACCR

UniProt

Q812Q3 - HDOX_BACCR

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Protein
Heme-degrading monooxygenase
Gene
isdG, BC_4542
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron By similarity.UniRule annotation

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Iron By similarity
Sitei66 – 661Transition state stabilizer By similarity
Metal bindingi76 – 761Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: UniProtKB-HAMAP
  2. heme oxygenase (decyclizing) activity Source: UniProtKB-HAMAP
  3. iron ion binding Source: UniProtKB-HAMAP
  4. monooxygenase activity Source: UniProtKB-KW

GO - Biological processi

  1. heme catabolic process Source: UniProtKB-HAMAP
  2. iron assimilation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBCER226900:GJEU-4538-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-degrading monooxygenase (EC:1.14.99.3)
Alternative name(s):
Heme oxygenase
Iron-regulated surface determinant
Iron-responsive surface determinant
Gene namesi
Name:isdG
Ordered Locus Names:BC_4542
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001417: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Heme-degrading monooxygenaseUniRule annotation
PRO_0000270072Add
BLAST

Proteomic databases

PRIDEiQ812Q3.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi226900.BC4542.

Structurei

3D structure databases

ProteinModelPortaliQ812Q3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2329.
KOiK07145.
OMAiFRESHSH.
OrthoDBiEOG6GTZMS.

Family and domain databases

HAMAPiMF_01272. Heme_degrading_monooxygenase.
InterProiIPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR023953. IsdG.
[Graphical view]
PfamiPF03992. ABM. 1 hit.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 1 hit.

Sequencei

Sequence statusi: Complete.

Q812Q3-1 [UniParc]FASTAAdd to Basket

« Hide

MIIVTNTAKI TKGNGHKLIE RFNKVGKVET MPGFLGLEVL LTQNTVDYDE    50
VTISTRWNAK EDFQGWTKSA AFKDAHSHQG GMPEYILDNK IAYYDVKVVR 100
MPMAAAQ 107
Length:107
Mass (Da):12,034
Last modified:June 1, 2003 - v1
Checksum:iE98EA5B28C19575C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP11450.1.
RefSeqiNP_834249.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP11450; AAP11450; BC_4542.
GeneIDi1206887.
KEGGibce:BC4542.
PATRICi32605203. VBIBacCer54481_4700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016877 Genomic DNA. Translation: AAP11450.1 .
RefSeqi NP_834249.1. NC_004722.1.

3D structure databases

ProteinModelPortali Q812Q3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226900.BC4542.

Proteomic databases

PRIDEi Q812Q3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP11450 ; AAP11450 ; BC_4542 .
GeneIDi 1206887.
KEGGi bce:BC4542.
PATRICi 32605203. VBIBacCer54481_4700.

Phylogenomic databases

eggNOGi COG2329.
KOi K07145.
OMAi FRESHSH.
OrthoDBi EOG6GTZMS.

Enzyme and pathway databases

BioCyci BCER226900:GJEU-4538-MONOMER.

Family and domain databases

HAMAPi MF_01272. Heme_degrading_monooxygenase.
InterProi IPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR023953. IsdG.
[Graphical view ]
Pfami PF03992. ABM. 1 hit.
[Graphical view ]
SUPFAMi SSF54909. SSF54909. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14579 / DSM 31.

Entry informationi

Entry nameiHDOX_BACCR
AccessioniPrimary (citable) accession number: Q812Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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