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Protein

Diadenylate cyclase

Gene

dacB

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.UniRule annotation

Catalytic activityi

2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diadenylate cyclaseUniRule annotation (EC:2.7.7.85UniRule annotation)
Short name:
DACUniRule annotation
Alternative name(s):
Cyclic-di-AMP synthaseUniRule annotation
Short name:
c-di-AMP synthaseUniRule annotation
Gene namesi
Name:dacBUniRule annotation
Ordered Locus Names:BC_4920Imported
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)Imported
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Probably oligomerizes.UniRule annotation

Protein-protein interaction databases

STRINGi226900.BC4920.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FB5X-ray1.99A/B/C1-201[»]
ProteinModelPortaliQ812L9.
SMRiQ812L9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ812L9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 201DACInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the adenylate cyclase family. DacB/CdaS subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiCOG1624. LUCA.
OMAiAFIQTGT.

Family and domain databases

Gene3Di3.40.1700.10. 1 hit.
HAMAPiMF_00838. DacB. 1 hit.
InterProiView protein in InterPro
IPR014046. c-di-AMP_synthase.
IPR034693. CdaS.
IPR003390. DNA_integrity_scan_DisA_N.
IPR019457. Uncharacterised_YojJ_N.
PfamiView protein in Pfam
PF02457. DisA_N. 1 hit.
PF10372. YojJ. 1 hit.
PIRSFiPIRSF004793. UCP004793. 1 hit.
SUPFAMiSSF143597. SSF143597. 1 hit.
PROSITEiView protein in PROSITE
PS51794. DAC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q812L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEWGLSEEL KIQTKQMIEI AEKELSIMRN AIDKEDECIL CKMEDIHHML
60 70 80 90 100
ANVQTLAATY YIQAYLSPYT ESSSFITTAI QHLSARKHGA LIVVERNETL
110 120 130 140 150
EALIQTGTTL NAHLTAPLLE SIFYPGNPLH DGAVLVKNNH IVSAANILPL
160 170 180 190 200
TKSTEVDPEL GTRHRAAIGL SEKSDALILV VSEETGRTSF ALNGILYTIS

L
Length:201
Mass (Da):22,207
Last modified:June 1, 2003 - v1
Checksum:iE488834DD0839A28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA. Translation: AAP11793.1.
RefSeqiNP_834592.1. NC_004722.1.
WP_000545252.1. NC_004722.1.

Genome annotation databases

EnsemblBacteriaiAAP11793; AAP11793; BC_4920.
GeneIDi1207262.
KEGGibce:BC4920.
PATRICifig|226900.8.peg.5072.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ812L9_BACCR
AccessioniPrimary (citable) accession number: Q812L9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 5, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported