ID Q812G4_MOUSE Unreviewed; 481 AA. AC Q812G4; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 27-MAR-2024, entry version 150. DE SubName: Full=CASP8 and FADD-like apoptosis regulator {ECO:0000313|EMBL:AAH29223.1}; GN Name=Cflar {ECO:0000313|EMBL:AAH29223.1, ECO:0000313|MGI:MGI:1336166}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH29223.1}; RN [1] {ECO:0000313|EMBL:AAH29223.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N {ECO:0000313|EMBL:AAH29223.1}; RC TISSUE=Mammary tumor. Metallothionien-TGF alpha model. 10 month old RC virgin mouse. Taken by biopsy. {ECO:0000313|EMBL:AAH29223.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Belongs to the peptidase C14A family. CC {ECO:0000256|ARBA:ARBA00010134}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC029223; AAH29223.1; -; mRNA. DR RefSeq; NP_001276633.1; NM_001289704.2. DR RefSeq; NP_997536.1; NM_207653.5. DR RefSeq; XP_006495698.1; XM_006495635.3. DR RefSeq; XP_011236722.1; XM_011238420.2. DR RefSeq; XP_011236723.1; XM_011238421.2. DR RefSeq; XP_011236724.1; XM_011238422.1. DR RefSeq; XP_011236725.1; XM_011238423.2. DR RefSeq; XP_017169048.1; XM_017313559.1. DR AlphaFoldDB; Q812G4; -. DR SMR; Q812G4; -. DR MEROPS; C14.974; -. DR MaxQB; Q812G4; -. DR Antibodypedia; 19934; 1072 antibodies from 43 providers. DR DNASU; 12633; -. DR GeneID; 12633; -. DR KEGG; mmu:12633; -. DR UCSC; uc007bcn.3; mouse. DR AGR; MGI:1336166; -. DR CTD; 8837; -. DR MGI; MGI:1336166; Cflar. DR VEuPathDB; HostDB:ENSMUSG00000026031; -. DR HOGENOM; CLU_036904_4_3_1; -. DR OMA; NCFRSIH; -. DR OrthoDB; 2873736at2759; -. DR TreeFam; TF352765; -. DR BioGRID-ORCS; 12633; 34 hits in 76 CRISPR screens. DR ChiTaRS; Cflar; mouse. DR ExpressionAtlas; Q812G4; baseline and differential. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro. DR CDD; cd00032; CASc; 1. DR CDD; cd08337; DED_c-FLIP_r1; 1. DR CDD; cd08340; DED_c-FLIP_r2; 1. DR Gene3D; 3.40.50.1460; -; 1. DR Gene3D; 1.10.533.10; Death Domain, Fas; 2. DR InterPro; IPR029030; Caspase-like_dom_sf. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR001875; DED_dom. DR InterPro; IPR011600; Pept_C14_caspase. DR InterPro; IPR001309; Pept_C14_p20. DR InterPro; IPR015917; Pept_C14A. DR PANTHER; PTHR48169:SF4; CASP8 AND FADD LIKE APOPTOSIS REGULATOR; 1. DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1. DR Pfam; PF01335; DED; 2. DR Pfam; PF00656; Peptidase_C14; 1. DR SMART; SM00115; CASc; 1. DR SMART; SM00031; DED; 2. DR SUPFAM; SSF52129; Caspase-like; 1. DR SUPFAM; SSF47986; DEATH domain; 2. DR PROSITE; PS50208; CASPASE_P20; 1. DR PROSITE; PS50168; DED; 2. PE 2: Evidence at transcript level; KW Apoptosis {ECO:0000256|ARBA:ARBA00022703}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 6..78 FT /note="DED" FT /evidence="ECO:0000259|PROSITE:PS50168" FT DOMAIN 97..175 FT /note="DED" FT /evidence="ECO:0000259|PROSITE:PS50168" FT DOMAIN 265..360 FT /note="Caspase family p20" FT /evidence="ECO:0000259|PROSITE:PS50208" SQ SEQUENCE 481 AA; 54875 MW; 433E07E2E5FA5A05 CRC64; MAQSPVSAEV IHQVEECLDE DEKEMMLFLC RDVTENLAAP NVRDLLDSLS ERGQLSFATL AELLYRVRRF DLLKRILKTD KATVEDHLRR NPHLVSDYRV LLMEIGESLD QNDVSSLVFL TRDYTGRGKI AKDKSFLDLV IELEKLNLIA SDQLNLLEKC LKNIHRIDLN TKIQKYTQSS QGARSNMNTL QASLPKLSIK YNSRLQNGRS KEPRFVEYRD SQRTLVKTSI QESGAFLPPH IREETYRMQS KPLGICLIID CIGNDTKYLQ ETFTSLGYHI QLFLFPKSHD ITQIVRRYAS MAQHQDYDSF ACVLVSLGGS QSMMGRDQVH SGFSLDHVKN MFTGDTCPSL RGKPKLFFIQ NYESLGSQLE DSSLEVDGPS IKNVDSKPLQ PRHCTTHPEA DIFWSLCTAD VSHLEKPSSS SSVYLQKLSQ QLKQGRRRPL VDLHVELMDK VYAWNSGVSS KEKYSLSLQH TLRKKLILAP T //