Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

CASP8 and FADD-like apoptosis regulator

Gene

Cflar

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CASP8 and FADD-like apoptosis regulatorImported
Submitted name:
CASP8 and FADD-like apoptosis regulator, isoform CRA_aImported
Gene namesi
Name:CflarImported
ORF Names:mCG_117843Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1336166. Cflar.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000026031.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065107.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7873DED (death effector)InterPro annotationAdd
BLAST
Domaini97 – 17579DED (death effector)InterPro annotationAdd
BLAST
Domaini265 – 36096CASPASE_P20InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.SAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00530000064199.
HOVERGENiHBG050918.
KOiK04724.
TreeFamiTF352765.

Family and domain databases

Gene3Di1.10.533.10. 3 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR001875. DED_dom.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
[Graphical view]
PfamiPF01335. DED. 2 hits.
[Graphical view]
SMARTiSM00115. CASc. 1 hit.
SM00031. DED. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50168. DED. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q812G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSPVSAEV IHQVEECLDE DEKEMMLFLC RDVTENLAAP NVRDLLDSLS
60 70 80 90 100
ERGQLSFATL AELLYRVRRF DLLKRILKTD KATVEDHLRR NPHLVSDYRV
110 120 130 140 150
LLMEIGESLD QNDVSSLVFL TRDYTGRGKI AKDKSFLDLV IELEKLNLIA
160 170 180 190 200
SDQLNLLEKC LKNIHRIDLN TKIQKYTQSS QGARSNMNTL QASLPKLSIK
210 220 230 240 250
YNSRLQNGRS KEPRFVEYRD SQRTLVKTSI QESGAFLPPH IREETYRMQS
260 270 280 290 300
KPLGICLIID CIGNDTKYLQ ETFTSLGYHI QLFLFPKSHD ITQIVRRYAS
310 320 330 340 350
MAQHQDYDSF ACVLVSLGGS QSMMGRDQVH SGFSLDHVKN MFTGDTCPSL
360 370 380 390 400
RGKPKLFFIQ NYESLGSQLE DSSLEVDGPS IKNVDSKPLQ PRHCTTHPEA
410 420 430 440 450
DIFWSLCTAD VSHLEKPSSS SSVYLQKLSQ QLKQGRRRPL VDLHVELMDK
460 470 480
VYAWNSGVSS KEKYSLSLQH TLRKKLILAP T
Length:481
Mass (Da):54,875
Last modified:June 1, 2003 - v1
Checksum:i433E07E2E5FA5A05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112968 Genomic DNA. No translation available.
BC029223 mRNA. Translation: AAH29223.1.
CH466548 Genomic DNA. Translation: EDL00095.1.
RefSeqiNP_001276633.1. NM_001289704.2.
NP_997536.1. NM_207653.5.
XP_006495698.1. XM_006495635.2.
XP_011236722.1. XM_011238420.1.
XP_011236723.1. XM_011238421.1.
XP_011236724.1. XM_011238422.1.
XP_011236725.1. XM_011238423.1.
UniGeneiMm.336848.
Mm.486313.

Genome annotation databases

EnsembliENSMUST00000069333; ENSMUSP00000065107; ENSMUSG00000026031.
ENSMUST00000114313; ENSMUSP00000109952; ENSMUSG00000026031.
GeneIDi12633.
KEGGimmu:12633.
UCSCiuc007bcn.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112968 Genomic DNA. No translation available.
BC029223 mRNA. Translation: AAH29223.1.
CH466548 Genomic DNA. Translation: EDL00095.1.
RefSeqiNP_001276633.1. NM_001289704.2.
NP_997536.1. NM_207653.5.
XP_006495698.1. XM_006495635.2.
XP_011236722.1. XM_011238420.1.
XP_011236723.1. XM_011238421.1.
XP_011236724.1. XM_011238422.1.
XP_011236725.1. XM_011238423.1.
UniGeneiMm.336848.
Mm.486313.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065107.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069333; ENSMUSP00000065107; ENSMUSG00000026031.
ENSMUST00000114313; ENSMUSP00000109952; ENSMUSG00000026031.
GeneIDi12633.
KEGGimmu:12633.
UCSCiuc007bcn.3. mouse.

Organism-specific databases

CTDi8837.
MGIiMGI:1336166. Cflar.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00530000064199.
HOVERGENiHBG050918.
KOiK04724.
TreeFamiTF352765.

Miscellaneous databases

ChiTaRSiCflar. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026031.

Family and domain databases

Gene3Di1.10.533.10. 3 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR001875. DED_dom.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
[Graphical view]
PfamiPF01335. DED. 2 hits.
[Graphical view]
SMARTiSM00115. CASc. 1 hit.
SM00031. DED. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50168. DED. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ812G4_MOUSE
AccessioniPrimary (citable) accession number: Q812G4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.